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All Journal Ahmad Dahlan Medical Journal
Rachma Greta Perdana Putri
Universitas Ahmad Dahlan, Yogyakarta
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Risk Factor for Erythropoietin Resistance in Hemodialysis Patient : Literature Review Rachma Greta Perdana Putri; Amanatus Sholikhah; Novi Sukirto
Ahmad Dahlan Medical Journal Vol. 1 No. 2 (2020): November 2020
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1419.976 KB) | DOI: 10.12928/admj.v1i2.3131

Abstract

Anaemia become the complication of chronic kidney disease (CKD) which was caused by decreasing of erythropoietin. Erythropoietin stimulating agent (ESA) therapy is one of therapy to overcome the problem, but until 34% of patients have lack of response to ESA treatment. Anaemia in CKD related to the worsen of the diseases, quality of life, and mortality of patients. Decreasing of the response to erythropoietin need to be evaluated to correct anaemic condition. This review is aim to explain the risk factor for erythropoietin resistance. The literature for this review was collected through PUBMED and google scholar. Erythropoietin is glycoprotein secreted 90% by interstitial cells of kidney and 10% by liver cells. The functions of erythropoietin are stimulate the proliferation and cells differentiation in bone marrow, and enhance erythropoiesis. Renal damage can inhibit the secretion of erythropoietin. In patients with ESA treatment, risk factors for resistance are iron deficiency, inadequate haemodialysis, inflammation, hyperparathyroid, nutrition disturbance, antibody mediated Pure Red Cell Aplastic (PRCA). The risk factor can be influenced by genetic variation. Conclusion of this review, there are several factor that influence the response of erythropoietin in hemodialisa patients. Hence, study related anaemia in CKD need further study to optimalize the treatment.
Vitamin K and The Immune System Rachma Greta Perdana Putri; Rosyida Awalia Safitri; Yuni Herliyanti
Ahmad Dahlan Medical Journal Vol. 3 No. 1 (2022): May 2022
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1648.541 KB) | DOI: 10.12928/admj.v3i1.6237

Abstract

Vitamin K is a vitamin fat-soluble with the main function as an anticoagulant. The active form of vitamin K can be divided into two categories, namely vitamin K1 (phylloquinone) can be found in photosynthetic plants and vitamin K2 (menaquinone) comes from bacteria, source in foods we can found this in fermented foods like natto or soybean product which fermented by Bacillus natto. This literature review was conducted through searching in database like PubMed, and Elsevier using keywords like vitamin K, Immune system, and inflammation. The role of vitamin K in physiological functions is well known worldwide, such as blood coagulation, bone metabolism, and regulation of several types of enzymes. Apart from this role, vitamin K also acts as a cofactor in several plasma proteins, so this vitamin can influence immune responses. Recent studies have found vitamin K links to inflammatory diseases. Vitamin K also induced autophagy pathway. However, information regarding the role of vitamin K in the immune system is limited.
Co-Authors Amanatus Sholikhah Novi Sukirto Rosyida Awalia Safitri Yuni Herliyanti