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Siti Fatimah
Ministry of Health, Poltekkes Kemenkes Palembang, Indonesia
Health Professions Medicine & Pharmacology Nursing Public Health Other

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Polymorphism for Interleukin-4 (-590 C/T) Promoter: Non-Association with Endometriosis Rika Hairunisyah; Siti Fatimah
International Journal Scientific and Professional (IJ-ChiProf) Vol. 1 No. 1 (2022): February
Publisher : Yayasan Rumah Ilmu Professor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (642.411 KB) | DOI: 10.56988/chiprof.v1i1.2

Abstract

Endometriosis is a benign gynecological disorder that often occurs in women of reproductive age, usually characterized by endometrial epithelium and stroma outside their usual location. It is estimated that this disease affects 56% of women worldwide. Various types of cytokines are associated with endometriosis, including interleukin IL-4, which inhibits the production of proinflammatory cytokines that stimulate active B cells and T cell proliferation, the differentiation of B cells into plasma cells. Il-4 promoter region polymorphism (-590C/T) is involved in genetic susceptibility to endometriosis. This study aims to determine whether Gen IL-4 (-590C/T) polymorphism indicates endometriosis. This study is an analytical observational study conducted at the Laboratory of Molecular Biology in Palembang City in August 2021, with the approach of Case-Control study. There were 70 samples divided into two groups, namely 35 cases and 35 controls. Determination of genotypes and alleles using PCR-RFLP and chi-square analyzed data to determine the relationship. The results showed no significant difference. The genomorphism of the Interleukin-4(-590C/T) gene cannot be used to indicate endometriosis susceptibility.
The Role Of “Il 10 (-2 1082 A/G)” Promoter Polymorphism In Ovarian Epithelial Cancer Pathogenesis Siti Fatimah; Rika Hairunisyah
International Journal Scientific and Professional (IJ-ChiProf) Vol. 1 No. 1 (2022): February
Publisher : Yayasan Rumah Ilmu Professor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (778.645 KB) | DOI: 10.56988/chiprof.v1i1.3

Abstract

Ovarian cancer (ovarian cancer) is the abnormal development of cells in one or two ovaries. Many cytokine functions are related to the development of immunological and inflammatory responses that play essential roles in cancer pathogenesis. Among the cytokines, interleukin 10 (IL-10) is an anti-inflammatory cytokine involved in the downregulation of cytotoxic and inflammatory cell-mediated responses. This study aims to determine the relationship between the Gene Promoter Polymorphism Interleukin 10 (-1082 A/G) with the incidence of ovarian epithelial cancer. This research is an observational analytical study conducted at the Molecular Biology Laboratory in Palembang City in October-December 2021. The number of samples was 60 respondents consisting of 30 case groups and 30 control groups. Data were obtained by genotype and allele using PCR-RFLP, which was then analyzed by Chi-Square test to determine whether there was a relationship. The results showed no significant relationship between the promoter of the IL 10 gene polymorphism (-1082 A/G) and the incidence of ovarian epithelial cancer.
Co-Authors Rika Hairunisyah