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All Journal Journal of Pain, Vertigo and Headache
Reza Rachmantoko
Universitas Brawijaya
Neuroscience

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DIABETIC NEUROPATHIC PAIN Reza Rachmantoko; Zamroni Afif; Dessika Rahmawati; Rodhiyan Rakhmatiar; Shahdevi Nandar Kurniawan
Journal of Pain, Headache and Vertigo Vol. 2 No. 1 (2021): March
Publisher : Journal of Pain, Headache and Vertigo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (485.154 KB) | DOI: 10.21776/ub.jphv.2021.002.01.3

Abstract

Diabetic Neuropathy is the most common complication from diabetes, which experienced in almost 90% diabetes patient. Evenly pain is one of the most common symptoms of diabetic neuropathic, but the pathophysiology mechanism of pain is not clearly known. The hyptosesis of toxicity of hyperglycemia on development of pain complication has been widely accepted globally, but there is other proposed hypothesis. Basic concept in management of painful diabetic neuropathic is exclusion of the other cause of painful peripheral neuropathy, improving glycemic control for prophylaxis therapy and medication use for alleviating pain. The first choice drug of therapy for alleviating pain are anticonvulsant, like pregabalin and gabapentin, and antidepressant, mainly that work on inhibiting serotonine and noradrenaline reuptake. In conclusion, the better understanding of painful diabetic neuropathic underlying mechanism can help to find a better management that improving the guideline quality in optimalizing pain control.
DIABETIC NEUROPATHIC PAIN Reza Rachmantoko; Zamroni Afif; Dessika Rahmawati; Rodhiyan Rakhmatiar; Shahdevi Nandar Kurniawan
Journal of Pain, Headache and Vertigo Vol. 2 No. 1 (2021): March
Publisher : Journal of Pain, Headache and Vertigo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jphv.2021.002.01.3

Abstract

Diabetic Neuropathy is the most common complication from diabetes, which experienced in almost 90% diabetes patient. Evenly pain is one of the most common symptoms of diabetic neuropathic, but the pathophysiology mechanism of pain is not clearly known. The hyptosesis of toxicity of hyperglycemia on development of pain complication has been widely accepted globally, but there is other proposed hypothesis. Basic concept in management of painful diabetic neuropathic is exclusion of the other cause of painful peripheral neuropathy, improving glycemic control for prophylaxis therapy and medication use for alleviating pain. The first choice drug of therapy for alleviating pain are anticonvulsant, like pregabalin and gabapentin, and antidepressant, mainly that work on inhibiting serotonine and noradrenaline reuptake. In conclusion, the better understanding of painful diabetic neuropathic underlying mechanism can help to find a better management that improving the guideline quality in optimalizing pain control.
Co-Authors Dessika Rahmawati Rodhiyan Rakhmatiar Shahdevi Nandar Kurniawan, Shahdevi Nandar Zamroni Afif