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All Journal Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) Jurnal Kesehatan Amanah
Pia Batmomolin
STIKes Maluku Husada
Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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EFEK EKSTRAK ETANOL DAUN PALA (MYRISCITA FRAGRANS) TERHADAP GAMBARAN HISPATOLOGI AORTA TIKUS (RATTUS NORVEGICUS) DIABETES Pia Batmomolin; Aulia Debby Pelu; Rokia Latuamury
Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) Vol. 1 No. 1 (2022): April :Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1107.188 KB) | DOI: 10.55606/jurrike.v1i1.477

Abstract

Daun pala (Myristica fragrans) gunakan masyarakat untuk mengobati bebrapa penyakit seperti nyeri. Bahan kimia yang terkandung dalam daun pala seperti saponin, polifenol, flavanoid, dan minyak atsiri. Untuk membuktikan aktivitas ekstrak etanol daun pala (myristica fragrans) terhadap aorta tikus (rattus norvegicus) diabetes. Penelitian ini merupakan jenis penelitian yang bersifat eksperimen laboratorium (laboratory experimen) secara in vivo menggunakan hewan coba tikus putih (rattus norvegicus) jantan galur wistar. Daun pala menggunakan pelarut etanol 96%. Diperoleh hasil maserasi sebanyak 300 g, dipekatkan dengan alat rotary evaporator diperoleh ekstrak kental sebanyak 42,673 g dengan %rendamen sebesar 14,23%. Didapatkan gambaran histologi terdapat lumen diameter yang lebih tipis dan lebih lebar dan sel busa pada bagian tunika intima dan media aorta tikus.
Uji Aktivitas Antidiabetes Ekstrak Etanol Daun Pala (Myiristica Fragrans) Terhadap Tikus(Rattus Norvegicust) Galur Wistar Jantan Yang Diinduksi Aloksan Aulia Debby Pelu; Pia Batmomolin; Salama Nurlette
Jurnal Kesehatan Amanah Vol. 5 No. 2 (2021): Oktober : Jurnal Kesehatan Amanah
Publisher : Universitas Muhammadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (181.732 KB) | DOI: 10.57214/jka.v5i2.142

Abstract

Nutmeg is known as a spice plant that has economic value and multipurpose because every part of the plant can be used in various industries. Compounds contained in nutmeg leaves include alkaloids, triterpenoids, tannins and 2 flavonoids. The purpose of this study was to determine the antidiabetic effect of ethanolic extract of nutmeg leaf (myristica frangrans) against male wistar white rats (Rattusnorvegicus) induced by alloxan administered intraperitoneally and compare its effectiveness with glibenclamide. This study used five treatment groups, namely the administration of aquadest as a negative control, glibenclamide as a positive control and ethanol extract of nutmeg leaves at a dose of 100 mg/kg BW, 200 mg/kg BW and 300 mg/kg BW as control treatments. Blood glucose measurements were carried out on day 0 (three days after induction), day 3, day 7 and day 10. The results showed that the ethanol extract of nutmeg leaf (myristica frangrans) TEST ACTIVITY can reduce blood glucose levels. At a dose of 300 mg/kg but not exceeding the decrease in blood sugar in the administration of glibenclamide. Giving ethanol extract of nutmeg leaves (myristica frangrans) also has activity to repair damage to pancreatic -cells in white rats (Rattus norvegicus) induced by alloxan.
Co-Authors Aulia Debby Pelu Rokia Latuamury Salama Nurlette