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All Journal Journal of Pharmaceutical and Medicinal Sciences
Nur Rahma Rumata
Sekolah Tinggi Ilmu Farmasi Makassar, Makassar, Indonesia, 90242
Medicine & Pharmacology

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Application Chemometrics-Assisted Fingerprinting Profiling of Extract Variation from Mangosteen (Garcinia mangostana L.) Using FTIR Method Budiman Yasir; Dewi Purwaningsih; Nur Rahma Rumata; Nurzadrina Wahyuddin; Muh Azwar AR; Nurul Hikmah; Noer Fauziah Rahman
Jurnal Farmasi dan Ilmu Pengobatan Vol 6 No 2 (2021): JPMS Volume 6 Issue 2
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32814/jpms.v6i2.134

Abstract

Garcinia mangostana L. (mangosteen) is a plant that comes from the tropics and is very loved by the public because of its pleasant taste. It has anti-diabetic effects, wound treatment, diarrhea, skin anti-infection, antioxidant, anticancer, anti-inflammatory, antimicrobial, antioxidant, and anti-tumorigenic effects. This study aims to determine the fingerprint profile of mangosteen seed extract and peel using variations of ethanol using FTIR and combined chemometrics with multivariate analysis methods. Mangosteen seeds and peels were extracted with a variety of solvents (ethanol 70%, and ethanol 96%) by maceration obtained 8 types of extracts. All extracts were analyzed through FTIR spectroscopy with KBr pellets and solvent methanol PA at wavelengths 400-4000 cm-1. Mangosteen peel and seed extracts have functional groups with fingerprint markers at wavelength positions 3414 cm-1 (O-H), 2964.59 cm-1 (C-H3), 2920.23 cm-1 (C-H2), and 2856.58 cm-1 (C-H2). Multivariate analysis showed loading plot of extract had normally distributed and 96% seed Bulukumba extract had a major effect on PC1 (0.424) and 96% ethanol peel Bulukumba extract (0.439). The plot score affected PC1 (20.1%) and PC2 (57.4%) with a similarity between 31.57-99.89% in the extracts. The correlation of each extract showed a very positive correlation with the equation (y = 0.9805x + 65.177; R² = 0.9926). The use of FTIR spectra in observing the fingerprint profile of mangosteen peel and seed extracts with ethanol variations and chemometric combinations is highly applicable and can be applied in the validation and study of the chemical components of plant extracts.
Activity Test of Ethyl Acetate Fraction and N-Hexane Fraction of Tamarind Leaf Extract (Tamarindus indica L.) Against Healing Burns and Incision Wounds in Rabbits (Oryctolagus cuniculus) Sitti Rahimah; Suwahyuni Mus; Zulkifli Zulkifli; Nurzadrina Nurzadrina; Nurhikmah Nurhikmah; Ismail Ismail; Rahmad Aksa; Nur Rahma Rumata
Jurnal Farmasi dan Ilmu Pengobatan Vol 7 No 1 (2022): JPMS Volume 7 Issue 1
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32814/jpms.v7i1.135

Abstract

Tamarind leaf (Tamarindus indica L.) is one of the forgotten plants that has potential as a medicine for burns based on its chemical compounds such as alkaloids, flavonoids, saponins and tannins. This study aims to determine the effect of giving the ethyl acetate fraction and the n-hexane fraction of tamarind leaves on the healing of burns in rabbits (Oryctolagus cuniculus). The test was carried out using 3 rabbits for each type of treatment, namely burns and incision wounds. Each experimental animal was induced as many as 6 wounds on each back of the rabbit with the following treatments: Wound I (negative control), Wound II (bioplacenton gel), Wound III (1% n-hexane fraction), Wound IV (n-hexane fraction). 3% hexane, Wound V (1% ethyl acetate fraction) and Wound Vl (3% ethyl acetate fraction). The macroscopic observations observed included color, edema, wound diameter, scab formation and opening and epitalization. Both hexane and ethyl acetate fraction of tamarind leaf extract had activity as a burn healer at concentrations of 1% and 3%.The conclusion was that the ethyl acetate fraction of 3% tamarind leaf extract had the best activity among other treatments.
Co-Authors Budiman Yasir Dewi Purwaningsih Ismail Ismail Muh Azwar AR Noer Fauziah Rahman Nurhikmah Nurhikmah Nurul Hikmah Nurzadrina Nurzadrina Nurzadrina Wahyuddin Rahmad Aksa Sitti Rahimah Suwahyuni Mus Zulkifli Zulkifli