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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science)
Vella Lailli Damarwati
School of Pharmacy, Faculty of Medicine and Health Science, University Muhammadiyah Yogyakarta, Bantul, Yogyakarta
Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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Formulation and Evaluation of Pulp Devitalization Paste Combination of Jatropha Curcas L. and Piper Crocatum Leaves Extract Vella Lailli Damarwati; Rahmat A Hi Wahid; Dyani Primasari; Sabtanti Harimurti; Lana Labibah; Syahrani Syahrani; Annisa Krisridwany
Media Farmasi: Jurnal Ilmu Farmasi Vol 19, No 2: September 2022
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (719.75 KB) | DOI: 10.12928/mf.v19i2.24041

Abstract

Dental caries require operative techniques such as pulp devitalization, but pulp devitalization materials that are often used by dentists have serious adverse effects that need to be considered, such as gingival injury and alveolar bone necrosis. Hence, the aim of the present study was to develop natural ingredients as an alternative to pulp devitalization from a combination of Jatropha curcas (Jatropha curcas L.) and red betel leaf extract (Piper crocatum) in the form of a paste and then conducting physical evaluation tests, Cyclooxygenase-2 (COX-2) tests, and also histopathological picture tests to the sample. The formulation of the pasta sample was carried out by the trituration method.  Formulation I (FI) contained 25% of Jatropha resin, 0.25% red betel leaf extract, and 25% Jatropha resin, 0.5% red betel leaf extract for Formulation II (FII). The paste produced was then evaluated for physical properties which consisted of organoleptic, homogeneity, pH, spreadability, adhesion, and anti-inflammatory power using test animals with COX-2 expression number parameters. The FI and FII treatment groups had met the requirements as paste formula. In the COX-2 expression test, FI has a COX-2 expression percentage value of 0.38% and a COX-2 suppression percentage value of 0.62%, while FII has a COX-2 expression percentage value of 0.59% and a COX-2 expression percentage of 0.59% and suppression of COX-2 of 0.41%. The optimal concentration of the paste formulation is the paste with a combination of 25% jatropha latex and 0.25% red betel leaf extract had been shown to have potential as an alternative to pulp devitalization
Co-Authors Annisa Krisridwany Dyani Primasari Lana Labibah Rahmat A Hi Wahid Sabtanti Harimurti Syahrani Syahrani