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All Journal PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat BERNAS: Jurnal Pengabdian Kepada Masyarakat Borneo Journal of Pharmacy
Alfin Syahrian Dwi Nugraha
Universitas Muhammadiyah Kalimantan Timur
Religion Agriculture, Biological Sciences & Forestry Humanities Dentistry Economics, Econometrics & Finance Education Environmental Science Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Borneo Journal of Pharmacy

 1 
Phytochemical Analysis and Anti-Inflammatory Activity of The Combination of Trigona apicalis propolis Extract and Honey Paula Mariana Kustiawan; Chaerul Fadly Mochtar Luthfi M; Sinta Ratna Dewi; Jati Pratiwi; Novia Misnawati Aisyiyah; Alfin Syahrian Dwi Nugraha; Irfan Muris Setiawan
Borneo Journal of Pharmacy Vol. 6 No. 2 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i2.4696

Abstract

Chronic inflammation is common in infectious diseases, rheumatoid arthritis, gout, and autoimmune diseases. However, using non-steroidal anti-inflammatory drugs (NSAIDs) is accompanied by dangerous side effects. Therefore, searching for safer alternative therapies without side effects is very important. A natural blend of ingredients produced by stingless bees from plants was potential as a remedy. Meanwhile, the potential of kelulut bee products from East Kalimantan as an anti-inflammatory is still unknown. This study aimed to compare the chemical composition of kelulut bee (Trigona apicalis) products and evaluate the anti-inflammatory effect of honey, propolis, and their combination. Propolis extract and honey were determined as secondary metabolites. An anti-inflammatory in vivo assay triggered the edema using carrageenan on male mice and measured its anti-inflammatory power value. Propolis extract and honey from T. apicalis have a promising anti-inflammatory effect and are significantly higher than the positive control. Meanwhile, combining propolis extract and honey did not enhance the anti-inflammatory effect. In addition, combining honey and propolis preparations with a ratio of 75 : 25 has a better effect on reducing edema volume than the other two combinations. Still, it is not better than the treatment with propolis extract or honey alone. The content of polyphenol compounds found in honey and propolis preparations is thought to have an important role in reducing edema volume.
Co-Authors Agnes Monica Ahmad Suwandi Asmiranda Agustinur Bambang Setiaji Chaerul Fadly Mochtar Deasy Nur Chairin Hanifa Dedi Setiawan Faldi Faldi Hasyrul Hamzah Irfan Muris Setiawan Jati Pratiwi Novia Misnawati Aisyiyah Paula Mariana Kustiawan Rahman Anshari Sinta Ratna Dewi Suwoko