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Fielda Djuita, Fielda
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New Advanced in Radiotherapy Djuita, Fielda
Indonesian Journal of Cancer Vol 3, No 5 (2009): Workshops 2009
Publisher : "Dharmais" Cancer Center Hospital

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https://www.scribd.com/doc/45502226/New-Advanced-in-Radiotherapy
Pengamatan Pengobatan Kanker Leher Rahim dengan Kombinasi Radiasi dan Khemoterapi serta Radiasi Saja -, Dewi; Ranuhardi, Doddy; Tadjudin, Hilman; Dwipoyono, Bambang; -, Sumannadi; -, Nasdaldy; Djuita, Fielda
Indonesian Journal of Cancer Vol 1, No 1 (2007): Jan - Mar 2007
Publisher : "Dharmais" Cancer Center Hospital

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Several clinical trial reported that chemo radiation has significant and equivalent improvement in pelvic failure and overall survival for uterine cervical cancer copared with radiation alone. The best result is certainly achieved by careful attention to management, including the overall treatment time because prolongation overall treatment time will reduce survival. For that reasons lue have reviewed 52 patients ; 14 patients without chemotherapy, 14 patients with chemotherapy docetaxel, 14 patiens with chemotherapy cisplatin and 10 patiens with paclitaxel. 33 patient stage HB and 19 patient stage 1UB. All patients received external radiation in prone position with 50 Gy dose and brachytherapy 3 X 70 Gy at point A. All patients clinically complete respons except 2 patients partial respons from group radiation alone and docetaxel but the overall treatment times from groups cisplatine and paclitaxel longer than others.Key words; Radiation, Uterine Cervical Cancer, Sensitizer Chemotherapy.
Manfaat Penggunaan Bantal Baji Dengan Posisi Prone Pada Penyinaran Kanker Leher Rahim Ardoni, Fitrus; Djuita, Fielda
Indonesian Journal of Cancer Vol 2, No 2 (2008): Apr - Jun 2008
Publisher : "Dharmais" Cancer Center Hospital

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Radioterapi berperan penting dalam pengobatan keganasan leher rahim, baik untuk stadium dini maupun lokal lanjut.Secara anatomi beberapa organ tubuh akan berada dalam lapangan radiasi daerah pelvis. Organ-organ tersebut adalah buli-buli,usus halus, kolon, ovarium dan uterus.Usus halus adalah salah satu organ yang harus sekecil mungkin masuk lapangan radiasi. Pemberian total dosis radiasi 46 - 50 Gy dapat meningkatkan kejadian efek samping pada usus halus yang berupa malabsorbsi dengan gejala yang timbul berupa diare, kram perut, meteorismus sampai obstruksi.Teknik radiasi eksterna daerah pelvis dengan menggunakan bantal baji yang diletakkan dibawah perut pasien (posisi pasien prone diatas meja tindakan) dapat mengurangi luas usus halus yang berada aalam lapangan radiasi dibandingkan dengan teknik radiasi eksterna pelvis yang konvensional (posisi pasien supine diatas meja tindakan).Dari penelitian terhadap 10 pasien kanker leher rahim di Instalasi Radioterapi RS.Kanker Dharmais Jakarta antara bulan Oktober 2007 sampai dengan Pebruari 2008 didapatkan perbedaan rata-rata luas usus halus yang berada dalam lapangan radiasi antara kedua teknik diatas cukup signifikan, yaitu 13,75 %. Rata-rata luas usus halus yang berada dalam lapangan radiasi pada teknik konvensional adalah 24,43 %, sedangkan dengan teknik menggunakan bantal baji 10,68 %.Bantal baji yang dipakai terbuat dari busa polyurethane dengan dua tipe, tipe A dengan kemiringan bantal 30°, dipakai untuk pasien dengan separasi < 15 cm dan tipe B dengan kemiringan bantal 45° yang dipakai untuk pasien dengan separasi s 15 cm.Kata kunci: posisi prone, radioterapi, kanker leher rahim
Radiasi pada Metastasis Tulang Djuita, Fielda; -, Defrizal
Indonesian Journal of Cancer Vol 1, No 4 (2007): Oct - Dec 2007
Publisher : "Dharmais" Cancer Center Hospital

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Radioterapi masih merupakan standar baku untuk pengobatan paliatif pada metastasis tulang. Pada artikel ini kami akan menguraikan kembali tentang patofisiologi, diagnosis dan pengobatan metastasis tulang khususnya dari sudut pandang radioterapi. Kami juga menyajikan data dari instalasi radioterapi RS. Kanker "Dharmais" yang merupakan penelitian retrospektif terapi radiasi pada metastasis tulang dalam kurun waktu 2005-20C6.Kata kunci : metastasis tulang, patofisologi, diagnosis, terapi radiasi.
Radiation Therapy in Early Stage Prostate Cancer Djuita, Fielda
Indonesian Journal of Cancer Vol 2, No 3 (2008): Jul - Sep 2008
Publisher : "Dharmais" Cancer Center Hospital

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Prostatektomi radikal adalah terapi yang efektif untuk pasien-pasien dengan kanker prostat lokal, sementara radioterapi juga modalitas terapi yang penting dalam penatalaksanaan kanker prostat lokal. Untuk penyakit resiko seaang dan resiko tinggi radiasi eksterna adalah salah satu terapi standar. Pemberian dosis tinggi akan meningkatkan angka respon bebas kekambuhan dan bebas ketahanan hidup. Brakhiterapi merupakan pengobatan kanker prostat lokal dan mempunyai kelebihan dari radiasi eksterna tetapi untuk penyakit dengan derajat keganasan sedang dan tinggi brakhiterapi saja tidak akan memberikan dosis yang cukup untuk jaringan disekitar prostat yang diketahui sebagai jalur penyebaran secara mikroskopik. Peningkatan dosis dimungkinkan dengan kombinasi radiasi eksterna dengan high dose rate brakhiterapi atau low dose rate brakhiterapi dan juga dapat dengan mengoptimalkan dosis yang diberikan dengan Intensity Modulated Radiation Therapy, Conformal Radiation dan Integrated Guided Radiation Therapy. Pada maKalah ini akan diuraikan perkembangan terapi kanker prostat lokal dan evidence basenya sesuai dengan tema Annual National Cancer Symposium ke 3 dan juga ditampilkan contoh kasus yang diradiasi di Rumah Sakit Kanker "Dharmais".Kata kunci: kanker prostat, deteksi dini, terapi radiasi.
Expression of γ-H2AX Using Immunofluorescence Assay as an Adaptive Response of PBMC in Radiation Workers at Dharmais Cancer Hospital Musthafa, Arifin; Djuita, Fielda; Kurnia, Iin
Indonesian Journal of Cancer Vol 12, No 2 (2018): April-June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (480.999 KB) | DOI: 10.33371/ijoc.v12i2.576

Abstract

Background: Exposure ionizing of radiation in radiation workers has the potential to cause DNA damage in the form of double strand break as the beginning of genomic instability. DNA damage can be observed with γ-H2AX as the biomarker of DNA double strand breaks (DSBs). The formation of γ-H2AX in the nucleus can occur after radiation exposure of 1 mGy. This study aims to determine the radiation effects in radiation work environments as a study of adaptive responses of peripheral blood mononuclear cell (PBMCs) after radiation by observing γ-H2AX foci expression..  Methods: Blood samples from nine radiation workers and nine non-radiation workers were irradiated with doses 0 Gy, 1 Gy, 1.5 Gy, and 2 Gy. Detection of γ-H2AX foci was done by immunofluorescence assay. The mean of γ-H2AX foci was counted in 50 PBMCs per sample. The comparison mean of γ-H2AX foci was analyzed using tindependent test.  Result: Based on the result study, there were no significant differences in the number of γ-H2AX foci without treatment (p = 0.807). The results of study showed that the formation of 2-3 foci per cell after exposure of 2 Gy increases along with the increasing irradiation doses.  Conclusion: The mean of index of γ-H2AX foci in PBMCs within normal limits between non-radiation workers and radiation workers and level of risk DSBs damage is relatively similar after exposure at doses 1 Gy, 1.5 Gy, and 2 Gy.  
Pengamatan Pengobatan Kanker Leher Rahim dengan Kombinasi Radiasi dan Khemoterapi serta Radiasi Saja Djuita, Fielda; -, Dewi; Ranuhardi, Doddy; Tadjudin, Hilman; Dwipoyono, Bambang; -, Sumannadi; -, Nasdaldy
Indonesian Journal of Cancer Vol 1, No 1 (2007): Jan - Mar 2007
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v1i1.5

Abstract

Several clinical trial reported that chemo radiation has significant and equivalent improvement in pelvic failure and overall survival for uterine cervical cancer copared with radiation alone. The best result is certainly achieved by careful attention to management, including the overall treatment time because prolongation overall treatment time will reduce survival. For that reasons lue have reviewed 52 patients ; 14 patients without chemotherapy, 14 patients with chemotherapy docetaxel, 14 patiens with chemotherapy cisplatin and 10 patiens with paclitaxel. 33 patient stage HB and 19 patient stage 1UB. All patients received external radiation in prone position with 50 Gy dose and brachytherapy 3 X 70 Gy at point A. All patients clinically complete respons except 2 patients partial respons from group radiation alone and docetaxel but the overall treatment times from groups cisplatine and paclitaxel longer than others.Key words; Radiation, Uterine Cervical Cancer, Sensitizer Chemotherapy.
Co-Authors Bambang Dwipoyono, Bambang Defrizal -, Defrizal Dewi - Doddy Ranuhardi, Doddy Fitrus Ardoni, Fitrus Hilman Tadjudin, Hilman Iin Kurnia Musthafa, Arifin Nasdaldy -, Nasdaldy Sumannadi -, Sumannadi