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All Journal IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Britain International of Exact Sciences Journal (BIoEx Journal)
Emmanuel Kitete Mulongo
Départment of Chemistry, Faculty of Science, University of Kinshasa, Kinshasa, Democratic Republic of the Congo
Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Mathematics Medicine & Pharmacology Physics

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Survey on Knowledge and on some Cases of Monkeypox: A Zoonotic Disease Endemic to Ubangian Eco-region of Democratic Republic of the Congo Koto-te-Nyiwa Ngbolua; Ruphin Djolu Djoza; Jeff Iteku Bekomo; Colette Masengo Ashande; Clarisse Falanga Mawi; Emmanuel Kitete Mulongo; Dorothée Tshilanda Dinangayi; Damien Sha Tshibey Tshibangu; Muhammad Ridwan; Pius T. Mpiana
Britain International of Exact Sciences (BIoEx) Journal Vol 4 No 3 (2022): Britain International of Exact Sciences Journal, September
Publisher : Britain International for Academic Research (BIAR) Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/bioex.v4i3.737

Abstract

The aim of this study was to investigate knowledge on Simian Orthopoxvirosis or Monkeypox in 180 people (129 males and 51 females) using the stratified probability sampling method. The majority of the respondents were (are): 35-50 years old (45.00%), with secondary education (43.33%), farmers (40.56%) and married (80.00%). The disease appears every year, thus demonstrating its endemic nature (98.33% of the respondents); 58.3% of the respondents said that the disease appears very often during the dry season, on the contrary, 40% of the respondents said that the disease appears during the rainy season. However, 1.7% of respondents said that the disease occurs every other season. The majority of respondents (81.1%) said that the cause of the disease is the consumption of bush meat, followed by wild vegetables (3.3%), fish (2.8%), livestock (2.2%) and caterpillars (1.7%) respectively. 65.2% of the respondents use Manihot esculenta to treat the disease locally, and followed by the leaves and wine of Raphia sese (13%), Morinda morindoides (13%) and Myrianthus arboreus (8.7%). Between January 17 and September 10, 2020, 40 cases of monkey pox were admitted to HGR of Businga (Maximum age: 42 years, minimum age: 1 year, average age: 13.3 years). 28 patients were male and 12 female. It is therefore advisable that surveillance be organized in wild animals and bush meat exposed on the market to ensure that they are not contaminated with Monkeypoxvirus. It is thus needed to establish a veterinary laboratory in Nord-Ubangi Province.
In silico screening of natural compounds from Jatropha curcas (Euphorbiaceae, Linn) and Jatropha gossypifolia (Euphorbiaceae, Linn) against SARS-CoV2, a COVID-19 main protease, using molecular docking approach Emmanuel Kitete Mulongo; Jason T Kilembe; Gedeon Ngiala Bongo; Koto-te-Nyiwa Ngbolua; Dorothée Tshilanda Dinangayi; Damien Sha Tshibey Tshibangu; Pius T Mpiana
IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Vol 7, No 3 (2022): October 2022
Publisher : IJFAC (Indonesian Journal of Fundamental and Applied Chemistry)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24845/ijfac.v7.i3.148

Abstract

SARS-Cov2, the COVID-19 main protease is set to be a good target for potential inhibitors especially from plants. 6LU7, the crystal structure of COVID-19 has been used for docking with natural compounds from Jatropha curcas and Jatropha gossypifolia. The following compounds identified within J. curcas have given good binding affinities than Azythromycin (control sample): 2-methyl anthraquinone, Curcusone D, Palmarumycin CP1, Apigenin, Jatropholone A, Jatropholone B, Spirocurcasone and Multidione. The best score is for Palmarumycin CP1 -8.2 Kcal/mol. All these compounds are R05 satisfied, good HIA scores and good pharmacokinetic properties. In J.gossypifolia, 2,24,25-Trihydroxylanosta-1,7-dien-3-one ; Cleomiscosin A, Citlalitrione, Gossypifan, Jatrophenone, Jatropholone A, Jatropholone B, Gadain, Gossypidien, Falodone and Gossypiline are having good binding affinities than Azythromycin (control sample). The best score is for Cleomiscosin A -8.2 Kcal/mol. All these compounds are R05 satisfied, good HIA scores and good pharmacokinetic properties. This study has shown anti-COVID-19 potential of these two plants.
Co-Authors Clarisse Falanga Mawi Colette Masengo Ashande Damien Sha Tshibey Tshibangu Dorothée Tshilanda Dinangayi Gedeon Ngiala Bongo Jason T Kilembe Jeff Iteku Bekomo Koto-te-Nyiwa Ngbolua Muhammad Ridwan Pius T Mpiana Pius T. Mpiana Ruphin Djolu Djoza