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All Journal World Nutrition Journal IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN)
Marcia Kumala
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Health Professions Medicine & Pharmacology Public Health

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Vitamin D serum level as a prognostic factor in 1 predicting mortality severe COVID-19 patients: An evidence based case report Heny Puspita; Marcia Kumala; Yohannessa Wulandari
World Nutrition Journal Vol. 6 No. 1 (2022): Volume 06 Issue 1, August 2022
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V06.i1.0002

Abstract

Introduction: The mortality rate of COVID-19 is still high. Many prognostic factors have been studied to decrease the mortality rate. One of the many factors is vitamin D status, known for years as an immunomodulator and anti-inflammatory agent. Vitamin D deficiency could worsen the symptoms of COVID-19 and ultimately lead to mortality. However, some literature shows controversial results. Methods: Literature research was conducted by advanced searching in Pubmed, Cochrane Library, Scopus, and ProQuest, using a combination of both MeSH Terms and Title/Abstract. After removing duplicates, these literature were screened according to the eligibility criteria. Appraisal and level of evidence of the final literature were determined based on Oxford Centre for Evidence-Based Medicine. Results: Two selected literature were relevant to answer our clinical question. The former is a retrospective cohort study by Radujkovic et al. (2020), while the latter is a prospective cohort study by Bennouar et al. (2020). Both show similar results that low vitamin D serum levels in severe COVID-19 patients can increase the in-hospital mortality risk. Conclusion: Vitamin D is one of the prognostic factors that can predict the mortality rate of severe COVID-19 patients. We suggest that vitamin D serum level can be measured regularly in COVID-19 patients and administered to patients with such deficiencies. Adequate vitamin D deficiency management is expected to lower the COVID-19 mortality rate.
THE EFFECTS OF CURCUMIN SUPPLEMENTATION ON GLYCAEMIC INDEX IN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME: AN EVIDENCE BASED CASE REPORT Marcia Kumala; Nurul Ratna Mutu Manikam
IJCNP : INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN Vol 6 No 1 (2023): IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN)
Publisher : Perhimpunan Dokter Gizi Klinik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54773/ijcnp.v6i1.133

Abstract

Background: PCOS is the most common cause of infertility around the world. PCOS is associated with impaired glucose tolerance and higher tendency to develop type 2 diabetes. Curcumin, which is known for its anti-inflammatory, antioxidant, and antidiabetic properties, may show promising effect in regulating blood glucose. Objective: This study aims to evaluate the effect of curcumin supplementation on improving glycaemic profile in women with PCOS. Methods: Literature searching was conducted by advanced searching in Pubmed, Cochrane Library, Scopus, and ProQuest database using MeSH Terms combined with Title/Abstract. After removing duplicates, the literatures were screened based on the eligibility criteria. Critical appraisal and level of evidence of the selected literatures were determined based on Oxford Centre for Evidence-Based Medicine. Results: Two selected literatures were relevant to answer our clinical question. The first literature is a systematic review/meta-analysis study by Chien et al (2021) and the latter is a randomized controlled trial by Asan et al (2020). Both literatures show that curcumin supplementation is beneficial in improving glycaemic profile in PCOS patients. These effects were marked by lower fasting blood glucose, insulin level, and HOMA-IR in curcumin group compared to the control group. Conclusion: Curcumin supplementation for at least 6 weeks significantly improve glycaemic profile in women with PCOS. Curcumin supplementation is also considered safe and well tolerable. However, more studies are needed to investigate further regarding the long-term effects of curcumin supplementation. Keywords: curcumin, turmeric, polycystic ovarian syndrome, glycaemic profile
Co-Authors Heny Puspita Nurul Ratna Mutu Manikam Yohannessa Wulandari