Article Per Year (5 Year)
p-Index From 2019 - 2024
0.61
P-Index
This Author published in this journals
All Journal Media Kedokteran Hewan
Adakole Adah
Department of Veterinary Physiology and Biochemistry, University of Ilorin, P. M. B. 1515, Ilorin, Nigeria
Medicine & Pharmacology Veterinary

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
Ergothioneine Modulates Biomarkers of Oxidative Stress, Biochemical Profiles and Rectal Temperatures of Arabian Stallions Following Exercise in A Hot-Humid Environment Adakole Adah; Joseph Ayo; Peter Rekwot; Tagang Aluwong; Deborah Adah
Media Kedokteran Hewan Vol. 33 No. 3 (2022): Media Kedokteran Hewan
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mkh.v33i3.2022.163-176

Abstract

These experiments were performed to determine the effect of ergothioneine (EGT) and environmental parameters on some physiological profiles of Arabian stallions following an 1800 m race in a hot-humid environment. Twelve stallions having a mean weight of 401 ± 7.33 kg and aged 5.28 ± 1.14 years were used as subjects. They were divided into two groups of treated stallions (n = 6) and untreated stallions (n = 6). Group I which was the experimental group was administered with EGT (0.5 mg/kg orally)every week for two months while group II which served as controls was not treated. The temperature and the relative humidity of the experimental site were determined for six days and on the day of the experiment. The temperature-humidity index (THI) was also calculated. Vital parameters and some biochemical parameters of all stallions were determined before the commencement, immediately after, and one hour after the exercise. Some biomarkers of oxidative stress and serum biochemical parameters (aspartate aminotransferase, creatinine and lactate dehydrogenase) of the stallions were also determined.The biochemical parameters were higher (P < 0.05) in the untreated group than in the treated group. The results obtained showed that EGT lowered the rectal temperature and modulated biomarkers of oxidative stress and biochemical profiles.
The Potentials of Ergothioneine in the management of diseases in animals Adakole Adah
Media Kedokteran Hewan Vol. 34 No. 1 (2023): Media Kedokteran Hewan
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mkh.v34i1.2023.36-52

Abstract

The amino acid histidine is the source of the special nutraceutical ergothioneine (ERG), which is a potent antioxidant. Higher plants and animals, who obtain it from the soil and their food, respectively, do not synthesize it; instead, they obtain it through particular microorganisms, such as actinobacteria and mushrooms. Solute carrier family 22, member 4 (SLC22A4), sometimes referred to as organic cation transporter novel type-1 is an incredibly selective transporter for the substance that is only present in animals (OCTN-1). Depending on how OCTN 1 is expressed in different tissues, particularly in those that are more susceptible to oxidative stress, such as erythrocytes, the buildup of ERG differs. ERG concentration is decreased in a number of chronic inflammatory illnesses, and it appears to have potent cytoprotective actions.It has been certified to be relatively safe by regulatory authorities compared to many other antioxidants.
Haematological Responses following Oestrus synchronisation and superovulation protocols in West African Dwarf Goats Adakole Adah
Media Kedokteran Hewan Vol. 34 No. 1 (2023): Media Kedokteran Hewan
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mkh.v34i1.2023.27-35

Abstract

Experiments were performed to evaluate the haematological (erythrocyte and leucocyte parameters) response of West African Dwarf goats following oestrus synchronisation and superovulation protocol. Twenty-four clinically healthy female goats aged 2.34 ± 0.4 years and average body weight of 13.83 ± 0.7 kg was used for the experiment. The goats were divided into two groups. Group I goats was synchronized using Controlled Internal Drug Release (CIDR) for 18 days with the first day of insertion as day 0. On day 16 following CIDR insertion into the vagina, a single dose of 500 IU equine chorionic gonadotropin (eCG) was administered to each doe intramuscularly while group II served as the control was subjected to the same housing and environmental conditions but was not synchronized. superovulation was induced with porcine follicle stimulating hormone (pFSH) which was injected intramuscularly at a rate of 5mg/kg in reducing doses twice a day at 06.00 h and 18.00 h for 3 days starting from 48hr i.e., 2 days before CIDR removal (day 17). A blood sample of 5 mL was collected by jugular venipuncture of each of the goats before the protocol (Day 0) and at the end of the protocol (Day 18). All erythrocyte parameters evaluated showed a significantly higher value in group II (control) compared to group I post-oestrus synchronisation while total leucocyte count, neutrophil count and neutrophil/lymphocyte ratio values obtained after the protocol were also higher in group I (P < 0.05) compared to group II. It is therefore concluded that oestrus synchronisation and superovulation may elicit stress in West African Dwarf goats and an appropriate antioxidant should be part of the protocol.
Co-Authors Deborah Adah Joseph Ayo Peter Rekwot Tagang Aluwong