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All Journal Jurnal Kedokteran Diponegoro Jurnal Aisyah : Jurnal Ilmu Kesehatan
Endang Mahati
Department of Pharmacology, Faculty of Medicine, Diponegoro University
Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Anti-atherogenic Effect of Mulberry Leaf Tea in Atherogenic Index on Rats Dyslipidemia Elvi Susanti; Mohammad Sulchan; Endang Mahati
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 7, No 3: September 2022
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (660.674 KB) | DOI: 10.30604/jika.v7i3.1013

Abstract

Dyslipidemia is a lipid metabolism disorder characterized by lipid fraction changes in the blood, such as an increase in total cholesterol, LDL, TG and a decrease in HDL, which is strongly associated with atherosclerosis. Mulberry leaves (Morus alba L.) contain quercetin and 1-deoxynojirimycin (DNJ), which help to lower cardiometabolic risk by reducing hyperlipidemia, oxidative stress and atherosclerosis. The objective of this study was to determine the effect of mulberry leaf tea (Morus alba L.) on the atherogenic index (AI) in Sprague Dawley rats with dyslipidemia. This study was true experimental research with a randomized pre and post-test control group design. A total of 30 male Sprague Dawley (SD) rats were randomly divided into five groups. Calculation of AI value: log (TG/HDL-C). Statistical analysis that was used was the paired t-test and one-way ANOVA test. The intervention of mulberry leaf tea with the dosage of 36 mg/100 g BW/day (P1) and 72 mg/100 g BW/day (P2) significantly reduced atherogenic index values. Simvastatin and P2 groups showed that there was no difference in atherogenic index values after the intervention. In conclusion, giving mulberry leaf tea reduced atherogenic index values in SD rats with dyslipidemia. Abstrak: Dislipidemia merupakan kelainan metabolisme lipid yang ditandai dengan perubahan fraksi lipid dalam darah seperti peningkatan kolesterol total, LDL, TG dan penurunan HDL yang berhubungan kuat pada kejadian aterosklerosis. Daun mulberry (Morus alba L.) mengandung kuersetin dan 1-deoxynojirimycin (DNJ) yang berguna dalam menurunkan risiko kardiometabolik dengan menurunkan keadaan hiperlipidemia, stress oksidatif dan aterosklerosis. Tujuan dari penelitian ini untuk mengetahui pengaruh teh daun mulberry (Morus alba L.) terhadap indeks aterogenik plasma (IAP) pada tikus Sprague Dawley dislipidemia. Penelitian ini merupakan penelitian true experimental dengan randomized pre and post test control group design. Sebanyak 30 ekor tikus Sprague Dawley (SD) jantan dirandomisasi menjadi 5 kelompok. Rumus perhitungan nilai IAP : log (TG/HDL-C). Analisis statistik yang digunakan adalah uji paired t-test dan uji one-way ANOVA. Intervensi teh daun mulberry dosis 36 mg/100 g BB/hari (P1) dan 72 mg/100 g BB/hari (P2) secara signifikan menurunkan nilai indeks aterogenik plasma. Pada kelompok S dan kelompok P2 menunjukkan bahwa tidak terdapat perbedaan nilai indeks aterogenik plasma setelah intervensi. Sehingga disimpulkan bahwa pemberian teh daun mulberry terbukti menurunkan nilai indeks aterogenik plasma pada tikus SD dislipidemia.
IDENTIFICATION OF SECONDARY METABOLITE COMPOUNDS IN TUNICATE (Polycarpa aurata) ASSOCIATED BACTERIA Sheila Raisa; Astika Widy Utomo; Rebriarina Hapsari; Endang Mahati
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 6 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i6.30103

Abstract

Background: Marine biodiversity in the last few decades has been explored and utilized as marine natural products. The secondary metabolites produced by marine organisms are utilized by humans in various aspects of life. One of the main source of secondary metabolites is marine invertebrates, such as tunicate. Several previous studies have shown that many metabolites have been identified in the last 40 years.Objective: This study aimed to identify the metabolite compounds produced by tunicate-associated bacteria.Methods: The two isolates of bacteria associated with tunicate Polycarpa aurata, Bacillus wiedmannii and Virgibacillus salarius, obtained from the culture collection of Tropical Marine Biotechnology laboratory, Faculty of Fisheries and Marine Sciences, Diponegoro University, Semarang were used as material in this study. This study was carried out in Integrated Laboratory Diponegoro University from July to September 2020. Laboratory experiment was conducted by culturing these bacteria in Zobell Marine Broth 2216 at room temperature. The incubated culture was then added with ethyl acetate in a ratio of 1: 2 and then the supernatant was separated and evaporated. Analysis of the tunicate-associated bacteria methanol extract was carried out using Gas Chromatography-Mass Spectrophotometry (GC-MS).Results: 3-N-Hexyl-Delta-9-Tetrahydrocannabinol compound (100%) was discovered by GC-MS analysis from the tunicate-associated bacteria B. wiedmannii and V. salarius extract.Conclusion: 3-N-Hexyl-Delta-9-Tetrahydrocannabinol compound is an isomer compound of Delta-9-Tetrahydrocannabinol (Δ9-THC) which needs further research on its application in medical and non-medical aspects.
Co-Authors Astika Widy Utomo Elvi Susanti Mohammad Sulchan Rebriarina Hapsari Sheila Raisa