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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences
Min Young Kim
Jeju Natl. Univ.
Agriculture, Biological Sciences & Forestry Environmental Science

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Phytochemicals, Antioxidant and Anticancer Properties of Camellia japonica L. Mistletoe Extracts: Phytochemicals, Antioxidant and Anticancer Properties of Camellia Mistletoe Min Young Kim; Ji Hye Kim
Journal of Tropical Life Science Vol. 12 No. 2 (2022)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.12.02.13

Abstract

The present study aims to investigate the phytochemical profiles, in vitro antioxidant and antiproliferative properties of methanol and 70% ethanol extracts of Camellia mistletoe. Both extracts were analyzed for contents of total flavonoid, total carotenoid and L-ascorbic acid, and antioxidant properties such as scavenging capacities (1,1-diphenyl-2-picrylhydrazyl, O2- and NOž), ferrous ion chelating and reducing power. MTT assay was used to assess the antiproliferative properties against human cancer cell lines. The results showed that the methanol extracts of Camellia mistletoe contained higher total flavonoids (16237 mg rutin equivalents/100 g) and carotenoids (49175 mg/100g) with higher DPPH (IC50 = 0.6 mg/mL), superoxide (IC50 = 0.6 mg/mL), nitric oxide (IC50 = 0.5 mg/mL) radical scavenging and reducing power (IC50 = 1.1 mg/mL) activities than those of ethanol extracts (p < 0.05). In addition, methanol extracts showed much higher antiproliferative activity against A375 (IC50 = 118.1 μg/mL) and HCT116 (IC50 = 148.4 μg/mL) cells than ethanol extracts whereas higher inhibitory effects of MCF7 (IC50 = 139.9 μg/mL), Hela (IC50 = 127.1 μg/mL) and HepG2 (IC50 = 84.2 μg/mL) cell proliferation in the ethanol extracts of Camellia mistletoe. The data from this study suggest that Camellia mistletoe is a potential source of phytochemical compounds with antioxidant and antiproliferative properties.
Effect of extraction solvent and harvest time on recovery of bioactive compounds, antioxidant and cancer cell growth inhibition activities of Korean Camellia mistletoe : Antioxidant and anticancer activities of Camellia mistletoe Min Young Kim
Journal of Tropical Life Science Vol. 13 No. 1 (2023)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.13.01.07

Abstract

This study aimed to determine the phytochemical profiles, in vitro antioxidant and antiproliferative properties of Korean Camellia mistletoe (Korthalsella japonica (Thunb.) Engl.) depending on the harvest time (August and November) and solvent (100% methanol, 70% ethanol and hot water). The Camellia japonica L. mistletoe extracts were analyzed for contents of total phenol, flavonoid, total carotenoid and L-ascorbic acid, and antioxidant properties such as scavenging capacities (1,1-diphenyl-2-picrylhydrazyl (DPPH) and NO•), ferrous ion chelating and reducing power. Concurrently, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay was used to assess the antiproliferative properties against human cancer cell lines; MCF (human breast cancer cells), Hela (human cervical cancer cells), A375 (human malignant melanoma cells), HCT116 (human colon cancer cells), HepG2 (human liver cancer cells) and A549 (human non-small cell lung adenocarcinoma cells). The results showed that extraction solvent and harvest time had significant impacts on antioxidant and anticancer activities, as well as selectivity for free phenolic compounds in Camellia japonica L. mistletoe. Among all the tested extracts the highest amounts of total phenolic and total flavonoids content were found in ethanol extracts of Camellia japonica L. mistletoe harvested in November, while the methanol extracts of Camellia japonica L. mistletoe collected in August showed the highest contents of total carotenoids and L-ascorbic acids compared to the other tested extracts. Additionally, the highest NO• radical scavenging activity was found in ethanol extracts, whereas the strongest DPPH radical scavenging activity was found in methanol extracts of Camellia japonica L. mistletoe harvested in November. Furthermore, methanol extracts showed much higher antiproliferative activity against all human cancer cells than ethanol extracts of Camellia japonica L. mistletoe harvested in November. In conclusion, the antioxidant and anticancer properties of Camellia japonica L. mistletoe showed significant dependence on the extraction solvent type and harvest time. With optimum harvest time and extraction solvent, they boast a wide range of promising applications in the medical, pharmaceutical, and food industries.
Antioxidant Property and Inhibition of Tyrosinase and Melanin Synthesis of the Korean Fir (Abies koreana Wilson) Needle Extracts: Antioxidant and skin-whitening activities of Abies koreana Min Young Kim; Ji Hye Kim
Journal of Tropical Life Science Vol. 13 No. 2 (2023)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.13.02.07

Abstract

Korean fir (Abies koreana Wilson) is traditionally used in folk medicine for its antibacterial, memory-enhancing, and anti-inflammatory properties. In this study, we evaluated the antioxidant and skin-whitening effects of the methanol and ethanol extracts of Korean fir needles. The extracts were tested for their antioxidant capacity using various assays, including radical scavenging (1,1-diphenyl-2-picrylhydrazyl, O2-, H2O2 and NOž), SOD-like, ferrous ion chelating, and reducing power assays. The total phenolic and flavonoid contents were determined by the Folin-Ciocalteu method. The non-toxic doses of the extracts were determined by MTT assay using human malignant melanoma SK mel-100 cells, and the tyrosinase activity and melanin contents were measured using an enzyme-substrate assay. The results showed that the antioxidant activity of the Korean fir needle extracts increased in a dose-dependent manner, as confirmed by their radical scavenging activities in the 2,2-diphenyl-1-1-picrylhydrazyl and 2,2-azino-bis-(3-ethylbenzthiazoline-6-sulfonic acid) assays. The Korean fir needle extract significantly reduced tyrosinase activity and melanin content in a dose-dependent manner (p < 0.01), suggesting its potential use as a skin-whitening agent. The methanol extracts of the Korean fir needles exhibited significantly higher phenolic (8306 mg gallic acid equivalents/100 g) content, with higher superoxide (IC50 = 4.22 mg/mL) and nitric oxide (IC50 = 1.50 mg/mL) radical scavenging activities and inhibition of tyrosinase and melanin synthesis than those of ethanol extracts (p < 0.05). Overall, our results demonstrate the potential of Korean fir (Abies koreana Wilson) needles as a source of tyrosinase inhibitors and antioxidants for inhibiting melanin biosynthesis, which could have applications in the cosmetic and pharmaceutical industries.
Co-Authors Ji Hye Kim