When someome penetrates into old age, they will have experience with physical changes, cognitive, and psychosocial . Most of the elderly have problems, when they start handling the change of that process. Mostly the elderly oftentimes have experience weakness, until the limited ability. As a consequence of these conditions, the quality of elderly life becomes unwell. The purpose of this research was to identify the factors which influence the quality of elderly life in the working area of Gayamsari Public Health Center, Semarang City. This research has independent variables such as physical factor, psychological factor, social factors, and environmental factor whereas a dependent variable is quality of life. The cross sectional design is used in this research. This research population was taken through elderly at the working area of Gayamsari Public Health Center, which amounts to 103 elderly, must be have’s inclusion and exclusion criteria. The data of this research were used by tipe of WHOQOL-BREF questionnaire data. The data had analyzed, using the simple linear regression test, and shown in the distribution table with d=0.05 significant level. The results of this research, showed there were influence by physical factors against the quality of life (p=0.004), social factors against the quality of life (0.000).