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All Journal Jurnal Sains dan Teknologi Nuklir Indonesia (Indonesian Journal of Nuclear Science and Technology)
Laila Roikhatul Jannah
Master Program of Chemistry, Faculty of Mathematics and Natural Sciences, Bandung Institute of Technology
Biochemistry, Genetics & Molecular Biology Energy Environmental Science Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Physics

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OPPORTUNITY TO PRODUCE RADIOISOTOPES ASTATINE-211 USING DECY-13 CONCEPTUAL DESIGN WITH COMPUTATIONAL APPROACH Badra Sanditya Rattyananda; Duyeh Setiawan; Ade Suherman; Muhamad Basit Febrian; Yanuar Setiadi; Laila Roikhatul Jannah
Jurnal Sains dan Teknologi Nuklir Indonesia (Indonesian Journal of Nuclear Science and Technology) Vol 23, No 1 (2022): February 2022
Publisher : HIMNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17146/jstni.2022.23.1.6713

Abstract

To catch up research gap with developed countries, Indonesia would build a cyclotron type accelerator that has the code name DECY-13. Detailed design and conceptual design of DECY-13 were published, thus to accelerated applied research of DECY-13, it is necessary to hold a preliminary study even before the cyclotron is commissioned. Astatine-211 (211At) is an alpha-rays emit radioisotope that is easy to direct labeling for targeted alpha therapy. Targeted alpha therapy (TAT) is the selectively deliver therapy that uses alpha-ray base radioisotopes that are produced using a cyclotron like DECY-13. DECY-13 was designed to accelerate a proton to 13 MeV. however, it does not rule out the possibility of accelerating alpha particles. A computational approach will be used to simulate the possibility of DECT-13 to accelerate alpha particles for the production of 211At from natural Bismuth. The theoretical calculation was predicting that the alpha particle (helium nucleus) could be accelerated in DECY-13, but the energy decreased increasingly after hitting niobium layer twice and helium cooling layer into 4.06 MeV. The 0.924 grams of natural bismuth was irradiated 8 hours long and 4 hours cooling. At EOB was not found radioisotopes, radioactivity and dose emitted. The inability to produce 211At because the energy of the accelerated alpha particles has not been able to penetrate the bismuth nucleus. the continuation simulation successfully predicts if the niobium layer thinned to 125 mm can be obtained 211At with low impurity. on the other side, if the energy of DECY-13 would be increased until 28 MeV 211At can be produced but the impurity was increased to. Furthermore, DECY-13 Cyclotron is not able to produce 211At from bismuth-209. To obtain 211At from 209Bi, it is necessary to create another engineering design of cyclotron or use another proton-base reaction.
Co-Authors Ade Suherman Badra Sanditya Rattyananda Duyeh Setiawan Muhamad Basit Febrian Yanuar Setiadi