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All Journal Jurnal Kedokteran Diponegoro
Novi Kusumaningrum
Department of Dermatology and Venereology, Universitas Diponegoro
Medicine & Pharmacology

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CORRELATION OF INTERLEUKIN-23 SERUM LEVELS IN MEN WITH ACNE VULGARIS: A PRELIMINARY STUDY Maria Hotmaida Carolina Munthe; Novi Kusumaningrum; Amallia Nuggetsiana Setyawati; Astika Widy Utomo; Santoso Santoso
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 2 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i2.29955

Abstract

Background: Acne vulgaris (AV) is an inflammatory condition of pilosebaceous unit that is common in adolescents and young adults. The pathogenesis of AV is multifactorial, one of which is inflammation. Interleukin-23 (IL-23) has an important role in the activity of T helper 17 (Th17) cells that produce IL-17 in chronic inflammation.Objective: To determine the correlation between serum IL-23 levels and AV severity in men.Methods: This is an analytical observational preliminary study with a cross-sectional design involving 15 male subjects with AV who were divided into groups of AV severity based on Lehmann’s criteria. The subjects were examined for serum IL-23 levels. Data were analyzed using Spearman’s Rho non-parametric correlation test to determine the correlation between variables.Results: Mean IL-23 serum levels in men with AV was 111,05 ± 115,27 pg/ml, with mild AV was 210,57 ± 122,038 pg/ml, moderate AV was 103,65 ± 91,15 pg/ml and severe AV was 18,94 ± 15,76 pg/ml. There is a significant correlation between IL-23 serum levels and AV severity in men. (p = 0,001). Serum IL-23 levels decreased with increasing AV severity (r = -0,756).Conclusion: There is a strong negative correlation between IL-23 serum levels and AV severity in men.
Co-Authors Amallia Nuggetsiana Setyawati Astika Widy Utomo Maria Hotmaida Carolina Munthe Santoso Santoso