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All Journal Jurnal Saintika Medika Jurnal Kesehatan Islam : Islamic Health Journal
Shandi Andara Putra
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Obesity As A Risk Factor For Hypertension Febri Endra Budi Setyawan; Riana Widyastuti; Shandi Andara Putra; Ashifarachma Ekasari; Novianita Anugrah Islami; Nur Hafidhah Fitriani; Lingga Caraka Putri
Saintika Medika Vol. 18 No. 2 (2022): December 2022
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol18.SMUMM2.24113

Abstract

Background: In Baruharjo Public Health Center in Trenggalek, hypertension is ranked 1 as the most common cases in 2021. Based on the results of Riskesdas in 2018, the increase in cases of hypertension in Indonesia is in line with the prevalence of obesity. Method: This study is a Systematic review. 34 journals published at least 5 years ago were acquired. Journals contain the topic of health problems about obesity as a risk factor for hypertension. Result: Through the process of reviewing and selecting articles, researchers obtained 34 journals that matched the inclusion and exclusion criteria, and were relevant to this research. From all the 34 journals that we have reviewed, most of them found a significant relationship between obesity and hypertension. Only 1 journal that showed if there was no relationship between obesity and hypertension, but there is still no further explanation about the reason why there was no relationship between both of them. Discussion: Someone with an overweight/obese BMI is four until eight times more likely to have hypertension than a person with normal BMI. Obesity can cause hypertension through various mechanisms, either directly or indirectly. The pathophysiology of obesity induced hypertension involve activation of the sympathetic nervous system and the RAAS or renin-angiotensin-aldosterone system. In addition, the occurrence of endothelial dysfunction and the abnormalities in kidney function are also important factors in the occurrence of hypertension in obese people. Every 10 percent increase in body weight can increase systolic levels by about 5.6 mmHg. Conclusion: Obesity is strongly associated with hypertension. Losing even a small amount of weight if you're overweight or obese and or controlling your weight can help reduce your blood pressure.
Efektivitas Ekstrak Daun Kelor Dalam Remodelling Left Ventricular Hypertrophy Pada Tikus Model Hipertensi Dian Yuliartha; Cindy Rizky Annisa; Shandi Andara Putra
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 12 No. 1 (2023): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v12i1.19846

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ABSTRAK Hipertensi menyebabkan kerja ventrikel kiri semakin berat sehingga dapat meningkatkan kadar radikal bebas (ROS) dalam jantung sehingga sarkomer dan miosit otot jantung menjadi hipertorfi. Flavonoid merupakan antioksidan yang dapat ditemukan pada daun kelor dan dan berfungsi menurunkan pembentukan ROS serta dapat menurunkan tekanan darah. Tujuan penelitian ini untuk mengetahui efektivitas daun kelor (Moringa oleifera Lam.) dalam menurunkan tekanan darah dan ketebalan ventrikel kiri tikus putih strain wistar model hipertensi. Penelitian menggunakan desain eksperimental. Sampel yang digunakan adalah tikus putih jantan strain wistar yang dibagi menjadi 5 kelompok (kontrol negatif, positif, perlakuan 1, 2, dan 3). Kelompok kontrol negatif diberi pakan dan minum selama 56 hari, kelompok kontrol positif diinduksi hipertensi selama 42 hari dan pemberian aquadest selama 14 hari, kelompok perlakuan 1, 2 dan 3 diberi induksi hipertensi selama 42 hari dan induksi ekstrak daun kelor dengan dosis bertingkat selama 14 hari. Hasil uji T berpasangan menunjukkan bahwa terdapat penurunan tekanan darah yang bermakna dengan pemberian ekstrak daun kelor di kelompok perlakuan 3. Analisa ketebalan ventrikel kiri menggunakan ANOVA dengan hasil terdapat perbedaan yang signifikan (p=0,001). Hasil post hoc Bonferroni menunjukkan perbedaan yang signifikan pada kelompok perlakuan 3. Uji regresi menunjukkan hasil 47,2%. Kesimpulan penelitian ini adalah pemberian ekstrak daun kelor memberikan pengaruh signifikan pada penurunan tekanan darah dan ketebalan ventrikel kiritikus putih strain wistar model hipertensi. Kata Kunci : Ekstrak daun kelor (Moringa oleifera Lam.), hipertensi, tekanan darah sistolik, tekanan darah diastolik, hipertrofi ventrikel kiri
Co-Authors Ashifarachma Ekasari Cindy Rizky Annisa Dian Yuliartha Febri Endra Budi Setyawan Lingga Caraka Putri Novianita Anugrah Islami Nur Hafidhah Fitriani Riana Widyastuti