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All Journal Global Medical and Health Communication Ebers Papyrus
Enikarmila Asni
Department Of Biochemistry, Faculty Of Medicine, Universitas Riau, Pekanbaru
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Effects of Proteasome Inhibitor on Catalase Expression and Intima-media Thickness in the Aorta of Atherosclerotic Rats Ismawati Ismawati; Enikarmila Asni; Ilhami Romus; Mukhyarjon Mukhyarjon; Winarto Winarto; Muhammad Fadhillah Arif; M Derillovyandra Dwi Anugrah
Global Medical & Health Communication (GMHC) Vol 10, No 3 (2022)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v10i3.9508

Abstract

Various studies have been carried out to obtain proper management for atherosclerosis. Proteasome, a subcellular enzyme complex, is a potential therapeutic target for atherosclerosis. However, the effect of proteasome inhibitors on atherosclerosis still needs to be explored. It was an experimental study with a post-test-only control group design conducted at the Faculty of Medicine, Universitas Riau in Juni–November 2021. This study aimed to analyze the effects of proteasome inhibitors on catalase expression and intima-media thickness (IMT) in the thoracic aorta of atherosclerotic rats. Fifteen male Wistar rats were randomly divided into three groups (five rats per group), namely rats given standard feed (control, group I), rats induced atherosclerosis (group II), and rats induced atherosclerosis and given proteasome inhibitor (group III). The proteasome inhibitor, bortezomib, 50 µg/kgBW/day was given intraperitoneally on days one and three. After 4 days, rats were terminated, and the thoracic aorta was taken for the IMT analysis and catalase expression assessment using immunohistochemistry. Catalase expression was carried out quantitatively using Adobe Photoshop software. Analysis of variance test was used to compare the expression of catalase and IMT. A p value<0.05 was considered statistically significant. The results showed a significant decrease in IMT in group III compared to group II and an increase in catalase expression in group III compared to group II but not statistically significant. This study concludes that administration of bortezomib 50 µg/kgBW in atherosclerotic rats could inhibit thickening tunica intima-media in the thoracic aorta, although not significantly increasing the catalase expression.
PENGARUH AIR PERASAN UMBI BAWANG MERAH (Allium ascalonicum L.) TERHADAP KADAR MALONDIALDEHID (MDA) PLASMA MENCIT Enikarmila Asni
Ebers Papyrus Vol. 16 No. 1 (2010): EBERS PAPYRUS
Publisher : Medical Faculty Universitas Tarumanagara

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Abstract

Ketidakseimbangan oksidan dan antioksidan dalam jaringan dapat menyebabkan kondisi stres oksidatif yang berakibat kerusakan dan kematian sel. Malondialdehid, sebuah produk dari peroksidasi lipid, sering digunakan sebagai salah satu indikator untuk mendeteksi kerusakan jaringan akibat stres oksidatif. Secara turun temurun, masyarakat telah meng­ gunakan bawang merah (Allium ascalonicum L.) setelah mengkonsumsi makanan tinggi lemak. Penelitian ini bertujuan untuk menganalisis pengaruh air perasan umbi bawang sebagai antioksidan pada tikus yang diberi diet tinggi lemak berdasarkan perubahan ka­ dar MDA plasma. Penelitian ini adalah eksperimental laboratoris dengan post test only design. Mencit dikelompokkan menjadi 3 yaitu kelompok diet normal, kelompok diet tinggi lemak, dan kelompok diet tinggi lemak ditambah perasan air bawang dengan konsentrasi20%, 40% dan 80%. Hasil penelitian menunjukkan bahwa terdapat perbedaan kadar MDA plasma yang bermakna (p<0,05) antara kelompok diet lemak tinggi yang ditambahkan perasan 80% bawang merah dibandingkan kelompok diet tinggi lemak saja. Penamba­ han air perasan bawang 80% dalam kelompok pakan tinggi lemak dapat menurunkan kadar MDA plasma ke kadar yang tidak berbeda bermakna dengan kelompok pakan normal (p>O.OS). Namun  , tidak ada perbedaan yang signifikan antara penambahan air bawang di 20% dan 40%'s pemerasan. Dari penelitian ini dapat disimpulkan bahwa air perasan dapat menurunkan kadar plasma MDA tikus dengan konsentrasi 80% sebagai konsentrasi yang terbaik.
Co-Authors Ilhami Romus Ismawati ismawati M Derillovyandra Dwi Anugrah Muhammad Fadhillah Arif Mukhyarjon Mukhyarjon Winarto Winarto