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All Journal Narra J Trends in Infection and Global Health
Fauzul Husna
Department of Pharmacology, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Antioxidant and antiaging activity of Cinnamomum burmannii and Michelia champaca extract and combinations Waisul Qarani; Fauzul Husna; Winda Yulia; Zulkarnain Zulkarnain; Dedy Syahrizal; Basri A. Gani; Nirwana L. Sary; Bantari WK. Wardhani
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.111

Abstract

Aging is a natural skin process that occurs due to intrinsic and extrinsic factors, such as excessive exposure to ultraviolet light (photoaging). The mechanism of damage involves the production of excess free radicals that trigger oxidative stress in the skin. Determining the natural products that have high antioxidant activities as antiaging is up most important. Cinnamomum burmannii and Michelia champaca are typical Aceh plants that are believed to have high antioxidant effects. The aim of this study was to determining the contents of C. burmannii and M. champaca as well as to determine the antioxidant and antiaging activities of either individually or combinations. The qualitative phytochemical and semi-quantitative analysis of the extracts were conducted using gas chromatography and mass spectroscopy (GC-MS). The antioxidant activity was examined by radical scavenging using the DPPH radical while the antiaging activity was tested the tyrosinase enzyme inhibition test. The phenolic and flavonoid contents of C. burmannii were higher than M. champaca (66.34 vs 24.71 mg gallic acid equivalent/gr) and (80.52 vs 60.20 mg quercetin equivalent/gr). The inhibitory concentration (IC₅₀) of M. champaca extract in inhibiting DPPH indicated that M. champaca had a better antioxidant activity than C. burmannii. The combination of C. burmannii and M. champaca extracts had a lower IC₅₀ compared to M. champaca alone. C. burmannii and M. champaca extract had a weak potential to inhibit tyrosinase activity (IC₅₀ value ≥1000 µg/mL). In conclusion, this study indicates that M. champaca and C. burmannii have strong antioxidant activities and these might associate with polyphenol contents.
SARS-CoV-2 infection and male fertility problems Ika Inda Bani; Zulkarnain Zulkarnain; Gholib Gholib; Dedy Syahrizal; Fauzul Husna; Winda Yulia; Mulkan Azhari
Trends in Infection and Global Health Vol 2, No 2 (2022): December 2022
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/tigh.v2i2.29426

Abstract

In 2019, the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), has killed more than 6.6 millions of people around the world as of end of 2022. The long-term impact of COVID-19 is persisted, including its impact on male reproduction. SARS-CoV-2 enters into host cells using the angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) receptors. Both of these receptors are expressed more in men, and therefore men are more susceptible to SARS-CoV-2. COVID-19 potentially cause infertility by damaging testicular tissues and interfering with the process of spermatogenesis. A decrease in serum levels of testosterone, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) as well as a decrease in sperm quality in men with COVID-19 compared to healthy men of the same age has been reported in several studies. Utilizing existing research data, this study aims to explore in detail of how SARS-CoV-2 tends to affect male fertility.
Co-Authors Bantari WK. Wardhani Basri A. Gani Dedy Syahrizal Gholib Gholib Ika Inda Bani Mulkan Azhari Nirwana L. Sary Waisul Qarani Winda Yulia Zulkarnain Zulkarnain