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All Journal Biology, Medicine, & Natural Product Chemistry Journal of Indonesian Dental Association Jurnal AKAL: Abdimas dan Kearifan Lokal Jurnal Kedokteran Gigi Terpadu Jurnal Abdimas Kesehatan Terpadu
Soesanto, Sheila
Department Of Pharmacology, Faculty Of Dentistry, Universitas Trisakti, Indonesia
Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Transportation

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Journal : Biology, Medicine,

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The Antibacterial and Antibiofilm Efficacy of Citrullus lanatus Rind Ethanol Extract Against Aggregatibacter actinomycetemcomitans Cokro, Wilbert Alvin Genesis; Natassya, Priska; Soesanto, Sheila
Biology, Medicine, & Natural Product Chemistry Vol 13, No 2 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.132.367-372

Abstract

Watermelon (Citrullus lanatus) rind contains secondary metabolite compounds which exhibit antimicrobial effects against Gram-positive and Gram-negative bacteria. Aggregatibacter actinomycetemcomitans can cause tissue damage and bone resorption, leading to aggressive periodontitis. Chlorhexidine as golden standard antimicrobial mouthwash can cause tooth staining. There is a need for herbal remedies with fewer side effects as an alternative treatment for periodontitis. This study aims to determine the antibacterial and antibiofilm efficacy of C. lanatus rind ethanol extract against A. actinomycetemcomitans. This is an experimental laboratory in vitro with a post-test-only control group design. The antibacterial test was conducted using the plate count method and the antibiofilm test using the microtiter plate biofilm assay method. The samples used were ethanol extract of C. lanatus rind 3.125%, 6.25%, 12.5%, 25%, 50%, and 100%, chlorhexidine 0.2% as positive control, distilled water, and BHI-B as negative control. As a result, extract concentrations from 12.5% to 100% exhibited antibacterial effects on A. actinomycetemcomitans equivalent to chlorhexidine. During the 3-hour incubation period, extract at 25% and 100% concentrations on all incubation times showed a better antibiofilm effect than chlorhexidine. It can be concluded that ethanol extract of C. lanatus rind had the potential as an alternative antibiofilm agent against A. actinomycetemcomitans.
Co-Authors Armelia Sari Widyarman Cokro, Wilbert Alvin Genesis Eddy Evangelista Rachel Hepziba Halim, Johni Joko Kusnoto Natassya, Priska Octarina Octarina Octarina Pratama Sarwono, Aditya Yuliasari, Hani