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Elfita Elfita
a:1:{s:5:"en_US";s:146:"Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Sriwijaya, Jl. Indralaya-Prabumulih, South Sumatera, Indonesia";}
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Environmental Science Materials Science & Nanotechnology Physics

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Chemical Characterization of Secondary Metabolite from the Endophytic Fungus Trichordema reecei isolated from The Twig of Syzygium aqueum Ummi Hiras Habisukan; Elfita Elfita; Hary Widjajanti; Arum Setiawan
Science and Technology Indonesia Vol. 6 No. 3 (2021): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1262.307 KB) | DOI: 10.26554/sti.2021.6.3.137-143

Abstract

Endophytic fungi are microorganisms that live in plants, without negative effects and are mutually related to hosting plants. Exploration of bioactive compounds from Endophytic fungi is easier and cheaper because they do not require a large area, a short growing time, and uncomplicated mixed compounds. Endophytic fungi are new and patent base secondary metabolites but they are not extensively characterized and investigated for the exploration of raw materials for drugs. The purpose of this study was to obtain antioxidant secondary metabolites from Endophytic fungi that live in the Syzygium aqueum medicinal plant. In this study, Endophyticfungi were isolated from S. aqueum twigs and molecular identification. The secondary metabolites were isolated by chromatographic method and chemical structure identified by spectroscopy. Antioxidant activity was evaluated by method 1,1diphenyl-2-picryl hydrazyl (DPPH). Phylogenetic analysis showed the Endophytic fungi of S. aqueum twig have a high similarity with the Trichordema reecei twig 19MSr.B2.3. The secondary metabolites from the ethyl acetate extract of the liquid culture of the fungus were identified as (4-hydroxy-3-(4-hydroxyphenyl)-5 oxotetrahydrofuran-2-yl) methyl acetate with IC50= 75.13 ????g/mL. The secondary metabolites can be developed into starting molecules for potential antioxidant agents.
Tritirachium oryzae and Other Endophytic Mediated Jambu Bol (Syzygium malaccense) are Potential as an Antioxidant Yustina Hapida; Elfita Elfita; Hary Widjajanti; Salni
Science and Technology Indonesia Vol. 7 No. 2 (2022): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1747.884 KB) | DOI: 10.26554/sti.2022.7.2.220-227

Abstract

Natural bioactive substances have been discovered produced of intracellular fungi. Intracellular fungi, as well as endophytic fungi, it can be found in organs are leaves, stems, roots, fruits, flowers, and seeds. This study aimed to specify for antioxidant activity of intracellular fungi Jambu Bol (Syzygium malaccense) mediated and identify secondary metabolites compounds. The liquid culture was partitioned with ethyl acetate solvent. Using chromatographic techniques, extracts were separated from their secondary metabolites with antioxidant activity apply the DPPH procedure. Its chemical structure was determined using NMR spectroscopic research, and endophytic fungi were recognized using phenotypic characteristics and molecular classification. The endophytic fungus isolation yielded four isolates: YF11, YF12, YF13, and YF14. YF12, with an IC50 of 53.03 g/mL, was the fungus that exhibited good antioxidant activity. Pure chemical secondary metabolites compounds were identified as 2-(4-hydroxyphenyl)-4-methoxytetrahydrofuran-3-ol. Tritirachium oryzae was identified as the endophytic fungus YF12 based on morphological studies and a phylogenetic tree. To boost its antioxidant activity, more study is needed to perform a semi-synthetic reaction on this pure molecule
Co-Authors Arum Setiawan Hary Widjajanti Hary Widjajanti Salni Ummi Hiras Habisukan Yustina Hapida