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Kevin Luke
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Health Professions Medicine & Pharmacology Nursing Public Health

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Losartan sebagai Regimen Penurun Serum Asam Urat pada Penderita Gout dengan Hipertensi: Florence Pribadi; Ronald Torang Marsahala Panggabean; Angelarita Djami Raga; Ellysia Yuvena Maheswari; Berlian Ester Wakas; Almer Fathoni Syahda; Lola Adriani; Kevin Luke
Unram Medical Journal Vol 11 No 3 (2022): volume 11 no 3
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v11i3.739

Abstract

Asam urat (AU) merupakan produk akhir dari metabolisme purin yang terdistribusi pada plasma dan cairan synovial. Solubilitas AU pada air sangat rendah, sehingga pada konsentrasi 6.8 mg/dL dapat membentuk kristal, yaitu monosodium urat. Kristal yang mengendap di sendi dapat memicu proses inflammasi yang disebut dengan gout artritis (GA). Penatalaksanaan GA yang tidak optimal menyebabkan penurunan kualitas hidup yang signifikan. Losartan merupakan obat hipertensi yang bekerja dengan memblokade reseptor Angiotensin I, sekaligus memiliki efek menurunkan kadar AU. Losartan diduga menghambat transporter URAT1 pada tubulus ginjal, sehingga menganggu reabsorbsi AU dan menyebabkan efek urikosurik. Tinjauan ini akan membahas potensi Losartan sebagai regimen terapi penurun AU pada penderita gout dengan hipertensi.
OPIOID IN THE PAIN MANAGEMENT OF ACUTE GOUT ARTHRITIS: FRIEND OR FOE? Mega Nilam Sari; Florence Pribadi; Eva M. Anigomang; Gede T.W. Suara; Karmila A. Wardani; Kharisma A. Perdana; Lidya Anin; Yasmine P. Fadhilah; Kevin Luke
Jurnal Ilmiah Kesehatan Vol 16 No 01 (2023): Jurnal Ilmiah Kesehatan (Journal of Health Science) 
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/jhs.v16i01.3102

Abstract

Introduction: Intense and severe pain is the most common symptom of acute gout arthritis (GA) flare. A recent study revealed that opioids are commonly prescribed for acute gout flare. Objective: This review aims to explain current evidence of opioid usage in the management of pain for acute GA flare. Method: The literature search was conducted on PubMed and Google Scholar in June 2022. Relevant articles published in the last 10 years were included. Results: The evidence of opioid use in managing acute gout arthritis flares is scarce. Currently, no guidelines recommend opioids as an initial analgesic choice in managing acute GA flare. Opioids are indicated in the flare with severe kidney dysfunction if only oral corticosteroids and intra-articular corticosteroids are not effective in reducing pain. Conclusion: Opioids should be used as only adjuvant and last choice in selected cases.
Tatalaksana Serangan Gout Akut: Sebuah Tinjauan dari Tiga Pedoman Irwin Priyatna Kusumah; Florence Pribadi; Bella Meylani Lifindra; Helen Octavia Djoenaydy; Kevin Luke
Jurnal Ilmiah Kesehatan Vol. 16 No. 1 (2023): Jurnal Ilmiah Kesehatan
Publisher : Universitas Muhammadiyah Pekajangan Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48144/jiks.v16i1.1197

Abstract

Acute gout flare is one spectrum of gout disease. The flare is characterized by severe acute pain with signs of inflammation at the joint. Currently, there are three primary guidelines in managing gout flares, namely American College of Rheumatology (ACR), European League Against Rheumatism (EULAR), and Indonesian Rheumatology Association (IRA). The objective of this review is to analyze the management of gout flares among these guidelines. We compared three guildelines on managing acute gout flare based on their acute therapy initiation time, first-line treatment, additional treatment, and urate-lowering therapy initiation. Additional literature search was also conducted on PubMed and ScienceDirect to provide additional information to the guideline. All guidelines agreed that management of gout flares should be initiated as early as possible with colchicine or NSAIDs based on patient condition and contraindications. Oral or injected corticosteroid should be considered in patient with renal impairment or contraindications to colchicine or NSAIDs. In conclusion, most recommendations from three guidelines were similar. IRA 2018 are still suitable for managing acute gout flare for Indonesian population
Co-Authors Almer Fathoni Syahda Angelarita Djami Raga Bella Meylani Lifindra Berlian Ester Wakas Ellysia Yuvena Maheswari Eva M. Anigomang Florence Pribadi Gede T.W. Suara Helen Octavia Djoenaydy Irwin Priyatna Kusumah Karmila A. Wardani Kharisma A. Perdana Lidya Anin Lola Adriani Mega Nilam Sari Ronald Torang Marsahala Panggabean Yasmine P. Fadhilah