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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research
Fauzar
Division of Pulmonology, Department of Internal Medicine, Faculty of Medicine, Universitas Andalas/Dr. M. Djamil General Hospital, Padang, Indonesia
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

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Disseminated Tuberculosis in Breastfeeding Mother: A Case Report Dewi Oktavia Djasmi; Roza Kurniati; Fauzar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 17 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i17.734

Abstract

Background: Disseminated tuberculosis is defined as the involvement of two or more extrapulmonary organs due to Mycobacterium tuberculosis infection, which spreads hematogenously. Disseminated tuberculosis is a life-threatening condition, especially if diagnosis and treatment are delayed. This study aimed to describe disseminated tuberculosis in a breastfeeding mother. Case presentation: A 21-year-old woman was admitted to Dr. M. Djamil General Hospital with chief complaints of shortness of breath. The symptoms were accompanied by chronic cough, fever, night sweats, and weight loss. From the physical examination, there was a decrease in left lung breath sounds as high as right intercostal V. On the gene expert results, the PCR was positive for Mycobacterium tuberculosis. Chest X-ray shows a miliary pattern and left pleural effusion. Pleural fluid analysis reveals the presence of exudate. Patients were treated with anti-tuberculosis drugs, namely Isoniazid, rifampicin, pyrazinamide, and ethambutol, with pyridoxine. Anti-tuberculosis drug therapy in the intensive phase is given for 2 months and is continued for 6-9 months for the continuation phase, depending on the patient's clinical condition. Breastfeeding was still continued in this case. The patient's baby is advised to be evaluated for active tuberculosis. Conclusion: There are no contraindications for giving anti-TB drugs to breastfeeding mothers unless the mother has mammary TB or drug-resistant TB. In children under 5 years who have close contact with active tuberculosis patients and, after being evaluated, do not have active tuberculosis, the child is treated as suspected latent TB infection with Isoniazid for at least 6 months and accompanied by pyridoxine administration.
Disseminated Tuberculosis in Breastfeeding Mother: A Case Report Dewi Oktavia Djasmi; Roza Kurniati; Fauzar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 17 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i17.734

Abstract

Background: Disseminated tuberculosis is defined as the involvement of two or more extrapulmonary organs due to Mycobacterium tuberculosis infection, which spreads hematogenously. Disseminated tuberculosis is a life-threatening condition, especially if diagnosis and treatment are delayed. This study aimed to describe disseminated tuberculosis in a breastfeeding mother. Case presentation: A 21-year-old woman was admitted to Dr. M. Djamil General Hospital with chief complaints of shortness of breath. The symptoms were accompanied by chronic cough, fever, night sweats, and weight loss. From the physical examination, there was a decrease in left lung breath sounds as high as right intercostal V. On the gene expert results, the PCR was positive for Mycobacterium tuberculosis. Chest X-ray shows a miliary pattern and left pleural effusion. Pleural fluid analysis reveals the presence of exudate. Patients were treated with anti-tuberculosis drugs, namely Isoniazid, rifampicin, pyrazinamide, and ethambutol, with pyridoxine. Anti-tuberculosis drug therapy in the intensive phase is given for 2 months and is continued for 6-9 months for the continuation phase, depending on the patient's clinical condition. Breastfeeding was still continued in this case. The patient's baby is advised to be evaluated for active tuberculosis. Conclusion: There are no contraindications for giving anti-TB drugs to breastfeeding mothers unless the mother has mammary TB or drug-resistant TB. In children under 5 years who have close contact with active tuberculosis patients and, after being evaluated, do not have active tuberculosis, the child is treated as suspected latent TB infection with Isoniazid for at least 6 months and accompanied by pyridoxine administration.
The Effectiveness of Antiplatelet Therapy in COVID-19 Patients: A Narrative Literature Review Muhammad Ridhwan Fatharanifurqan; Rudy Afriant; Raveinal; Fauzar; Drajad Priyono
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 1 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i1.751

Abstract

Coagulopathy is a feature of severe COVID-19 disease and contributes to an increased risk of thromboembolic complications and death. This literature review aimed to describe the effectiveness of antiplatelet therapy in COVID-19 patients. There is an inverse relationship between the likelihood of COVID-19 infection, duration of illness and death, and use of antiplatelets for primary prevention. A study showed that COVID-19 patients who did not receive antiplatelet drugs had three times the risk of dying with antiplatelet drugs. This study shows the strong effect of antiplatelet drugs on reducing the mortality rate of COVID-19 patients. Another study showed that COVID-19 patients who received antiplatelet drugs had 1.18 times the risk of dying than those without antiplatelet drugs. This study shows that antiplatelet therapy does not affect the reduction in mortality in patients hospitalized with COVID-19. In conclusion, the effectiveness of antiplatelet administration in COVID-19 patients is still unclear, so further research is needed.
The Effectiveness of Antiplatelet Therapy in COVID-19 Patients: A Narrative Literature Review Muhammad Ridhwan Fatharanifurqan; Rudy Afriant; Raveinal; Fauzar; Drajad Priyono
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 1 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i1.751

Abstract

Coagulopathy is a feature of severe COVID-19 disease and contributes to an increased risk of thromboembolic complications and death. This literature review aimed to describe the effectiveness of antiplatelet therapy in COVID-19 patients. There is an inverse relationship between the likelihood of COVID-19 infection, duration of illness and death, and use of antiplatelets for primary prevention. A study showed that COVID-19 patients who did not receive antiplatelet drugs had three times the risk of dying with antiplatelet drugs. This study shows the strong effect of antiplatelet drugs on reducing the mortality rate of COVID-19 patients. Another study showed that COVID-19 patients who received antiplatelet drugs had 1.18 times the risk of dying than those without antiplatelet drugs. This study shows that antiplatelet therapy does not affect the reduction in mortality in patients hospitalized with COVID-19. In conclusion, the effectiveness of antiplatelet administration in COVID-19 patients is still unclear, so further research is needed.
The Role of Immunophenotyping in the Diagnosis of Acute Leukemia: A Narrative Literature Review Rivani Sintia Suratman; Rudy Afriant; Drajad Priyono; Raveinal; Fauzar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 2 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i2.772

Abstract

Leukemia is the expansion of leukocyte cells in the bone marrow, which results in an increase in the number of leukocyte cells in the blood circulation and abnormal cell proliferation in the lymphatic tissue. The diagnosis of leukemia is established based on anamnesis, physical examination, and laboratory and confirmed by supporting examinations such as bone marrow aspiration to immunophenotyping. This literature review aimed to describe the role of immunophenotyping in the diagnosis of acute leukemia. The working process of immunophenotyping consists of a group of cells stained with a fluorochrome-conjugated antibody as a dye that is targeted to antigens on the cell surface. Most of these antigens are assigned a cluster of differentiation (CD) numbers. In conclusion, immunophenotyping analysis using multiparameter flow cytometry is an essential tool in detecting leukemia. Immunophenotyping examination is very useful for determining the diagnosis of leukemia. Targeted therapy is one of the modalities of leukemia therapy that is selective for certain cells that can be given based on the results of immunophenotyping.
The Role of Immunophenotyping in the Diagnosis of Acute Leukemia: A Narrative Literature Review Rivani Sintia Suratman; Rudy Afriant; Drajad Priyono; Raveinal; Fauzar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 2 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i2.772

Abstract

Leukemia is the expansion of leukocyte cells in the bone marrow, which results in an increase in the number of leukocyte cells in the blood circulation and abnormal cell proliferation in the lymphatic tissue. The diagnosis of leukemia is established based on anamnesis, physical examination, and laboratory and confirmed by supporting examinations such as bone marrow aspiration to immunophenotyping. This literature review aimed to describe the role of immunophenotyping in the diagnosis of acute leukemia. The working process of immunophenotyping consists of a group of cells stained with a fluorochrome-conjugated antibody as a dye that is targeted to antigens on the cell surface. Most of these antigens are assigned a cluster of differentiation (CD) numbers. In conclusion, immunophenotyping analysis using multiparameter flow cytometry is an essential tool in detecting leukemia. Immunophenotyping examination is very useful for determining the diagnosis of leukemia. Targeted therapy is one of the modalities of leukemia therapy that is selective for certain cells that can be given based on the results of immunophenotyping.
Co-Authors Dewi Oktavia Djasmi Drajad Priyono Drajad Priyono Muhammad Ridhwan Fatharanifurqan Raveinal Rivani Sintia Suratman Roza Kurniati Rudy Afriant