Budi Riyanto Wreksoatmodjo, Budi Riyanto
Fakultas Kedokteran Dan Ilmu Kesehatan, Universitas Katolik Indonesia Atma Jaya, Jakarta, Indonesia.

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In connection with the publication in Bali Med J 2016, Volume 5, Number 2: 25-29, entitled "Intra-Arterial Heparin Flushing Increases Manual Muscle Test – Medical Research Councils (MMT-MRC) Score in Chronic Ischemic Stroke Patient " Machfoed, Moh Hasan; Usman, Fritz Sumantri; Barus, Jimmy; Wreksoatmodjo, Budi Riyanto; Gunawan, Dede; Bintang, Andi Kurnia; Tugasworo, Dodik; Subroto, Gatot; Lamsudin, Rusdi; Harsono, H.; Sulthan, Riza
BALI MEDICAL JOURNAL Vol 5 No 2 (2016)
Publisher : BALI MEDICAL JOURNAL

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In connection with the publication in Bali Med J 2016, Volume 5, Number 2: 25-29,entitled "Intra-Arterial Heparin Flushing Increases Manual Muscle Test – Medical Research Councils (MMT-MRC) Score in Chronic Ischemic Stroke Patient ", herewith, please allow us to do reviews of the study discussion. By assessing the discussion, it can be proved whether there are references that support the results of study.
HUBUNGAN ANTARA RIWAYAT PENYAKIT JANTUNG DENGAN TINGKAT KEPARAHAN STROKE ISKEMIK AKUT PERTAMA KALI Ignatius Ivan,* Budi Riyanto Wreksoatmodjo,** Octavianus Darmawan**
NEURONA Vol. 37 No. 1 Desember 2019
Publisher : Neurona Majalah Kedokteran Neuro Sains

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INTRODUCTION HISTORY OF HEART DISEASE SUCH AS ATRIAL FIBRILLATION ANGINA PECTORIS MYOCARDIAL INFARCTION HEARTFAILURE HAS A ROLE ON ISCHEMIC STROKE SEVERITY
PERBEDAAN GANGGUAN KOGNITIF SUBJEK STROKE ISKEMIK BERDASARKAN SISI HEMIPARESIS Gabriella,* Budi Riyanto Wreksoatmodjo,** Andre**
NEURONA Vol. 37 No. 2 Maret 2020
Publisher : Neurona Majalah Kedokteran Neuro Sains

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INTRODUCTION COGNITIVE IMPAIRMENT IN STROKE HAS A SIGNIFICANT IMPACT ON THE QUALITY OF LIFE AND IS DIFFERENT FROM THE LOCATION OF THE LESION PATIENTS WITH A LESION IN THE LEFT CEREBRAL HEMISPHERE TEND TO HAVE COGNITIVE IMPAIRMENT AND DEMENTIA
HUBUNGAN KOLESTEROL NONHDL TERHADAP FUNGSI KOGNITIF PADA PASIEN STROKE ISKEMIK DENGAN DEFISIT NEUROLOGIS RINGAN Aylenia Lysandra,* Budi Riyanto Wreksoatmodjo,** Josephine Retno Widayanti**
NEURONA Vol. 37 No. 3 Juni 2020
Publisher : Neurona Majalah Kedokteran Neuro Sains

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INTRODUCTION ISCHEMIC STROKE PATIENTS HAVE HIGHER RISK OF COGNITIVE DECLINE SEVERITY OF COGNITIVE IMPAIRMENT DEPENDS ON THE SEVERITY OF NEUROLOGICAL DEFICIT THE SEVERITY OF COGNITIVE IMPAIRMENT IS ALSO AFFECTED BY ABNORMAL NONHDL CHOLESTEROL LEVEL WHICH INCLUDES ATHEROGENIC LIPID THAT CAUSES ATHEROSCLEROSIS
Pengaruh Coronavirus Disease 2019 (COVID-19) terhadap Insiden dan Tatalaksana Penyakit Serebrovaskular Hamidjoyo, Billy Priyanto; Wreksoatmodjo, Budi Riyanto
Cermin Dunia Kedokteran Vol 48, No 8 (2021): CME - Continuing Medical Education
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (329.983 KB) | DOI: 10.55175/cdk.v48i8.1444

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COVID-19 dikenal dengan manifestasi klinis terkait saluran pernapasan seperti batuk, sesak, dan demam. Namun, saat ini telah banyak diteliti bahwa COVID-19 dapat menimbulkan gejala di luar sistem pernapasan, salah satunya ke sistem saraf. Pelaporan kejadian stroke pada pasien COVID-19 masih bervariasi, namun pada pasien COVID-19, khususnya yang bergejala berat terdapat kondisi hiperkoagulasi yang dapat menyebabkan komplikasi trombotik seperti trombosis vena dalam dan diduga berkaitan dengan risiko stroke pada pasien COVID-19.COVID-19 is known for its clinical manifestations related to the respiratory tract such as cough, shortness of breath, and fever. However, currently it has been widely studied that COVID-19 can cause symptoms outside the respiratory system, one of which is the nervous system. Reports of stroke events in COVID-19 patients still vary, but in COVID-19 patients, especially those with severe symptoms, there is a hypercoagulable condition that can cause thrombotic complications such as deep vein thrombosis and is thought to be associated with the risk of stroke in COVID-19 patients.
Pengaruh Social Engagement terhadap Fungsi Kognitif Lanjut Usia di Jakarta Wreksoatmodjo, Budi Riyanto
Cermin Dunia Kedokteran Vol 41, No 3 (2014): Farmakologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (617.314 KB) | DOI: 10.55175/cdk.v41i3.1153

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Peningkatan harapan hidup manusia akan menambah populasi lanjut usia diikuti dengan peningkatan masalah, antara lain penurunan fungsi kognitif. Salah satu faktor risiko penurunan fungsi kognitif ialah social engagement yang dipengaruhi oleh lingkungan tempat tinggal. Penelitian dilakukan menggunakan metode cross sectional di kelurahan Jelambar dan Jelambar Baru, Jakarta atas 286 lanjut usia yang tinggal di keluarga dan di panti werdha menunjukkan adanya pengaruh social engagement terhadap fungsi kognitif lanjut usia, terutama di kalangan panti werdha. Social engagement buruk berhubungan dengan gangguan fungsi kognitif, social engagement buruk berhubungan dengan fungsi kognitif yang lebih rendah. Komponen social engagement yang paling berperan terhadap fungsi kognitif para lanjut usia adalah aktivitas di masyarakat dan keanggotaan di kelompok masyarakat lain (selain posyandu).The improvement of life expectancy has increased old-age population in the world. This condition will increase the problems among elderly, among others is cognitive decline. One of the risk factors for cognitive decline is social engagement that can be influenced by living environment. This research was done with cross sectional method in kelurahan Jelambar and Jelambar Baru on 286 respondents living in family and institution. Social disengagement was associated with lower cognitive function The most important components of social engagement are to become a member of social/community society and to be active in the community. 
Komplikasi Sistem Saraf Pusat pada COVID-19 Esterita, Tasia; Wreksoatmodjo, Budi Riyantoo
Cermin Dunia Kedokteran Vol 48, No 11 (2021): Kardio-SerebroVaskular
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (129.359 KB) | DOI: 10.55175/cdk.v48i11.1552

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Coronavirus disease-19 disebabkan oleh virus SARS-CoV-2 yang menyebabkan pandemi sejak Maret 2020. COVID-19 tidak hanya menyebabkan komplikasi pernapasan dan kardiovaskular, tetapi dapat menyebabkan komplikasi sistem saraf pusat yang juga berkontribusi terhadap mortalitas dan morbiditas. Beberapa komplikasi sistem saraf pusat pada COVID-19 adalah stroke iskemik, stroke hemoragik, meningoensefalitis, acute transverse myelitis, dan ensefalopati. Stroke iskemik pada COVID-19 disebabkan oleh beberapa mekanisme, di antaranya koagulopati, disfungsi endotel, kardioemboli, invasi virus ke sistem saraf pusat, dan terapi imunoglobulin. Stroke hemoragik dapat disebabkan oleh kerusakan endotel akibat inflamasi menyebabkan disregulasi tekanan darah yang meningkatkan risiko stroke hemoragik. Meningoensefalitis pada COVID-19 disebabkan invasi virus langsung melalui cribriform plate atau karena kerusakan endotel yang menjadi pintu masuk SARS-CoV-2 ke otak. Mielitis transversa pada COVID-19 disebabkan hiperinflamasi sistemik, molecular mimicry, dan epitope spreading. Kegagalan organ multipel pada pasien COVID-19 akibat badai sitokin dapat menyebabkan ensefalopati. Coronavirus disease-19 is caused by the SARS-CoV-2 virus that has been causing a pandemic since March 2020. Besides respiratory and cardiovascular complications, COVID-19 can cause complications to central nervous system that also contribute to mortality and morbidity. Some central nervous system complications in COVID-19 are ischemic stroke, hemorrhagic stroke, meningoencephalitis, acute transverse myelitis, and encephalopathy. Ischemic stroke in COVID-19 is caused by several mechanisms, including coagulopathy, endothelial dysfunction, cardioembolism, viral invasion of the central nervous system and immunoglobulin therapy. Hemorrhagic stroke can be associated with blood pressure dysregulation caused by inflammational endothelial damage. Meningoencephalitis in COVID-19 can be caused by direct viral invasion through the cribriform plate or due to endothelial damage that facilitate SARS-CoV-2 entrance to the brain. Transverse myelitis in COVID-19 is caused by systemic hyperinflammation, molecular mimicry and epitope spreading. Multiple organ failure in COVID-19 patients due to a cytokine storm can lead to encephalopathy.
Pemeriksaan Neurologis pada Kesadaran Menurun Aprilia, Maureen; Wreksoatmodjo, Budi Riyanto
Cermin Dunia Kedokteran Vol 42, No 10 (2015): Neurologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (755.814 KB) | DOI: 10.55175/cdk.v42i10.961

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Dengan kemajuan teknologi medis beberapa puluh tahun terakhir ini, saat ini fungsi vital dapat dipertahankan secara “buatan”, meskipun fungsi otak telah berhenti. Hal tersebut akhirnya berimplikasi terhadap definisi kematian secara medis, yang kemudian memunculkan suatu konsep kematian batang otak sebagai penanda kematian. Pasien dalam kondisi koma harus menjalani pemeriksaan fisik umum, neurologi, dan pemeriksaan penunjang untuk menentukan penyebab kehilangan kesadarannya. Keadaan koma tanpa perbaikan dapat berlanjut masuk dalam keadaan mati batang otak. Kriteria kematian batang otak antara lain koma dinyatakan positif, penyebab koma diketahui, arefleks batang otak dinyatakan positif, tidak adanya respons motorik, dan apnea dinyatakan positif.With the advancement of technology, human vital functions can be artificially maintained eventhough the brain ceased to function. This condition raised a concern for a new concept of death. Patients in coma need to be thoroughly evaluated to find the cause, and the diagnosis of brain death needs certain criteria to be fulfilled. Coma without improvements can continue entering in a state of brain stem death. The criteria of brain stem death include positive coma, known causes of coma, positive brain stem arefleks, the absence of motor responses, and apnea.
Anosmia pada COVID-19 Samuel, Ishak; Wreksoatmodjo, Budi Riyanto
Cermin Dunia Kedokteran Vol 48, No 1 (2021): Penyakit Dalam
Publisher : PT. Kalbe Farma Tbk.

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Sejak tanggal 11 Maret 2020, WHO telah mendeklarasikan COVID-19 sebagai pandemi. Gejala COVID-19 yang paling umum adalah demam, malaise, dan batuk kering, namun dapat juga muncul gejala gangguan penghidu atau anosmia. Anosmia pada COVID-19 dapat disebabkan oleh invasi langsung oleh virus melalui epitel hidung dan bulbus olfaktorius pada reseptor ACE2. Anosmia pada COVID-19 ini dapat timbul tiba-tiba atau didahului oleh gejala ringan seperti batuk kering. Tatalaksana anosmia pada COVID-19 masih terus berkembang dan diteliti lebih lanjut.Since March 11, 2020, WHO has declared COVID-19 a pandemic. The most common symptoms of COVID-19 are fever, malaise, and dry cough, but there can also be symptoms of olfactory dysfunctions including anosmia. Anosmia in COVID-19 can be caused by direct viral invasion through the nasal epithelium and olfactory bulb at the ACE2 receptor. Anosmia in COVID-19 can spontaneously appear or preceded by mild symptoms such as dry cough. The management of anosmia in COVID-19 is still developing and needs more in-depth research. 
Aktivitas Kognitif Mempengaruhi Fungsi Kognitif Lanjut Usia di Jakarta Wreksoatmodjo, Budi Riyanto
Cermin Dunia Kedokteran Vol 42, No 1 (2015): Neurologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (140.709 KB) | DOI: 10.55175/cdk.v42i1.1047

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Salah satu masalah kesehatan utama di kalangan lanjut usia adalah kemunduran fungsi kognitif. Selama ini kegiatan yang melibatkan fungsi berpikir dianggap dapat memperlambat proses kemunduran fungsi kognitif. Penelitian atas 286 lanjut usia di Jakarta menunjukkan bahwa inaktivitas kognitif dikaitkan dengan risiko mempunyai fungsi kognitif buruk. Para lanjut usia yang tidak pernah masak sendiri dua kali lebih berisiko (HR 2,09; 95% CI: 1,43– 3,05), mereka yang tidak pernah menonton acara berita di televisi dua kali lebih berisiko (2,02; 1,47–2,77), mereka yang tidak mempunyai hobi hampir dua kali lebih berisiko (1,78; 1,18–2,68), dan mereka yang tidak pernah membaca koran atau buku hampir satu setengah kali lebih berisiko (1,48; 1,04–2,09) mempunyai fungsi kognitif buruk dibandingkan dengan mereka yang lebih dari sekali seminggu melakukan kegiatan-kegiatan tersebut.Cognitive decline is one of the most important problem among the elderly, and cognitive activities are supposedly can retard the decline of cognitive function. Research on 286 elderlies in Jakarta showed that cognitive activities did have influence on their cognitive function; elderlies who were never did cooking or preparing meals him/herself had twice the risk (HR 2,09; 95% CI: 1,43– 3,05), those who never watch news on television have twice the risk (2,02; 1,47–2,77), those who did not have a hobby have almost twice the risk (1,78; 1,18–2,68), and those who never read books or newspapers have 1,5 times the risk (1.48; 1,04–2,09) to have lower cognitive function.