Yukihiro Hama
Department of Radiation Oncology, Tokyo-Edogawa Cancer Centre, Edogawa Hospital, Tokyo

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Real-Time MRI-guided Radiation Therapy for Locally Advanced Pancreatic Tail Cancer in Contact with The Colon Yukihiro Hama; Etsuko Tate
Indonesian Journal of Cancer Vol 17, No 1 (2023): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i1.947

Abstract

Introduction: Curative radiation therapy for locally advanced pancreatic ductal adenocarcinoma (PDAC) is difficult when the tumor is in contact with the colon. In this regard, MRI-guided radiation therapy (MRgRT) provides real-time MRI during radiation therapy, resulting in highdose radiation delivery to the target while avoiding surrounding organs at risk (OARs), such as the intestinal tract. Case Presentation: A 94-year-old woman with locally advanced PDAC in the pancreatic tail underwent high-dose (72 Gy/30 fractions) real-time hypo-fractionated MRgRT to avoid irradiation of the colon. Three months after MRgRT, her serum CA 19-9 level normalized, and the tumor regressed completely. No adverse event or recurrence was noted during the six-month follow-up period.Conclusions: High-dose hypo-fractionated MRgRT may be a treatment option for a patient with locally advanced PDAC of the pancreatic tail, which is in contact with the colon.