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All Journal Dental Journal (Majalah Kedokteran Gigi) Indonesian Journal of Prosthodontics

Nike Hendrijantini

Department Of Prosthodontic, Faculty Of Dental Medicine, Universitas Airlangga, Surabaya

Author-ID : 597153

Dentistry

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Stem Cells Approach for Implant Therapy in Diabetes Model Kuntjoro, Mefina; Hendrijantini, Nike; Agustono, Bambang; Salim, Sherman
Indonesian Journal of Prosthodontic Special Issue 2021
Publisher : Indonesia Prosthodontic Association

Objective of Investigation: Dental implant osseointegration in patients with hyperglycemic conditions was reported to be delayed so the restoration procedure must be postponed. Mesenchymal Stem Cells (MSCs) is a tissue engineering material that has the potential to treat various systemic diseases. Human Umbilical Cord Mesenchymal Stem Cells (hUCMSCs) is proven to improve bone microenvironment and have osteogenic potential. Their excellent capability can be a new approach for osseointegration acceleration. The purpose of this study was to determine the capability of hUCMSCs to accelerate dentalimplant osseointegration in hyperglycemic condition through angiogenesis and osteoblastogenesis. Experimental methods used: 28 Wistar rats were injected intraperitoneally with Streptozotocin 20mg/kg body weight for 5 days in a row to make the diabetic model. The treatment was carried out after fasting blood sugar levels 300 mg/dl and waited 5 days for the glycation period. The source of stem cell is human umbilical cord which has been isolated and cultured until passage 6. The experimental animals were divided into 4 groups, namely the 2-week implant group (K1), the 4-week implant group (K2), the 2-week implant + hUCMSCs group (P1) and the 4-week implant + hUCMSCs group (P2). The variables examined were BIC (Bone Implant Contact), VEGF and Runx2 expression. Data were analyzed using Analysis of Variance (ANOVA). Result : BIC, VEGF and Runx2 expresssion was higher in treatment groups compared with control groups. The highest expression of VEGF and Runx2 occurred in the P1 and decreased in the P2 group. While for BIC in groups P1 and P2 remained high to maintain osseointegration. Conclusion : With the limitation of this study, stem cells was proven to accelerate the osseointegration of dental implants through osteoblastogenesis and angiogenesis in diabetes model.

Front teeth replacement with implant-supported crowns: A case report K.K., Michael Josef; Hendrijantini, Nike; A, Maretaningtias Dwi; W, Wiwik Herawati
Indonesian Journal of Prosthodontic Vol 2, No 1 (2021): June 2021
Publisher : Indonesia Prosthodontic Association

The use of dental implants to support fixed or removable restoration is widely used as treatment modality. The advantages are increased retention, chewing ability, and easy access to oral hygiene procedures. A missing tooth that needs to be replaced completely can be restored using an implant-supported crown. The aim of this study is to rehabilitate maxillary partial edentulous with implant supported crown. A 56-year-old female patient came to the clinic, wanted to replace partial edentulous after extraction of 11 and 21, needed fixed restoration in order to eat and chew well, and expected high aesthetic result as well. This patient had experienced using removable partial denture to replace her lost teeth . Patient wanted to have implant treatment with fixed restoration because she felt that her partial denture did not fit anymore, so the prosthodontic treatment option was using implant-supported crowns. Implant supported crown can be an option to replace partial edentulous.

The effect of combined Moringa oleifera and demineralized freeze-dried bovine bone xenograft on the amount of osteoblast and osteoclast in the healing of tooth extraction socket of Cavia cobaya Rostiny Rostiny; Eha Djulaeha; Nike Hendrijantini; Agus Pudijanto
Dental Journal (Majalah Kedokteran Gigi) Vol. 49 No. 1 (2016): March 2016
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Alveolar bone has an important role in providing support to teeth and dentures. Loss of support caused by alveolar resorption will cause functional and aesthetic problems. Preservation socket using bone graft is one way to maintain the dimensions of the alveolar bone. Moringa oleifera leaf can increase the activity of bone graft in the formation of new bone. Purpose: This study was aimed to evaluate the effect of combined Moringa oleivera leaf extract and demineralized freeze-dried bovine bone xenograft (DFDBBX) towards the formation of osteoblasts and osteoclasts in the tooth extraction sockets of cavia cobaya. Method: This study used 28 cavia cobayas divided into four groups. The combination of Moringa oleifera leaf extract and DFDBBX was inducted into the sockets of lower incisor tooth with certain dose in each group, ointment 1 containing PEG (a mixture of PEG 400 and PEG 4000) for control group, ointment 2 containing Moringa oleifera leaf extract and DFDBBX and PEG (at active subtance consentration of 0.5%) for group 1, ointment 3 containing Moringa oleifera leaf extract and DFDBBX and PEG (at active substance concentration of 1%) for group 2, and Ointment 4 containing Moringa oleifera leaf extract and DFDBBX and PEG (at active substance consentration of 2%) for group 3. paraffin block preparations were made for histopathology examination using hematoxylin eosin staining. Result: The results showed that there were significant differences of the number of osteoblasts and osteoclasts in each treatment group (p <0.05). Conclusion: It can be concluded that the combination of Moringa oleifera leaf extract and DFDBBX at 2% cocentration can increase the number of osteoblasts and decrease osteoclasts in the healing of tooth extraction sockets of cavia cobaya.

The Effect of a combination of 12% spirulina and 20% chitosan on macrophage, PMN, and lymphocyte cell expressions in post extraction wound Nike Hendrijantini; Rostiny Rostiny; Mefina Kuntjoro; Kevin Young; Bunga Shafira; Yunita Pratiwi
Dental Journal (Majalah Kedokteran Gigi) Vol. 50 No. 2 (2017): June 2017
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Tooth extraction is the ultimate treatment option for defective teeth followed by the need for dentures. Inflammation is one phase of the healing process that should be minimized in order to preserve alveolar bone for denture support. Macrophage, PMN and lymphocyte cells are indicators of acute inflammation. Spirulina and chitosan are natural compounds with the potential to be anti-inflammatory agents. Purpose: This research aimed to determine macrophage, PMN and lymphocyte cells of animal models treated with a combination of 12% spirulina and 20% chitosan on the 1st, 2nd and 3rd post-extraction day. Methods: Animal models were randomly divided into control (K) and treatment (P) groups. Each group was further divided into three subgroups (KI, KII, KIII and PI, PII, PIII). The post-extraction sockets of the control group animals were then filled with CMC Na 3%. Meanwhile, the post-extraction sockets of the treatment group members were filled with a combination of 12% spirulina and 20% chitosan. Subsequently, the number of PMN, macrophage and lymphocyte cells was analyzed by means of HE analysis on the 1st., 2nd. and 3rd. days. Statistical analysis was then performed using a T-test. Results: There was a decrease in PMN cells and an increase in macrophage and lymphocyte cells on Days 1, 2, and 3. Conclusion: It can be concluded that a combination of 12% spirulina and 20% chitosan can not only decrease PMN cells, but can also increase macrophage and lymphocyte cells on Days 1, 2 and 3 after tooth extraction.

Comparative in vitro study of the cytotoxicity of gelatine and alginate to human umbilical cord mesenchymal stem cells Nike Hendrijantini
Dental Journal (Majalah Kedokteran Gigi) Vol. 52 No. 1 (2019): March 2019
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Mesenchymal stem cells (MSCs) and scaffold combination constitute a promising approach currently adopted for tissue engineering. Umbilical cord-derived mesenchymal stem cells (hUC-MSCs) are easily obtained and non-invasive. Gelatine and alginate constitute a biocompatible natural polymer scaffold. At present, a cytotoxicity comparison of gelatine and alginate to hUC-MSCs is not widely conducted Purpose: This study aimed to compare the cytotoxicity of gelatine and alginate in hUC-MSCs in vitro. Methods: Isolation and culture were performed on hUC-MSCs derived from healthy full-term neonates. Flow Cytometry CD90, CD105 and CD73 phenotype characterization was performed in passage 4. 3-(4,5-dimethythiazol- 2-yl)-2,5-diphenyl tetrazolium bromide (MTT) colorimetric assay was performed to measure the cytotoxicity. The three sample groups were: (T1) hUC-MSCs with α-MEM (alpha-minimum essential medium) solution as control; (T2) hUC-MSCs with gelatine; (T3) hUC-MSCs with alginate Results: Flow cytometry of hUC-MSCs displayed positive CD90, CD105 and CD73 surface markers. Gelatine and alginate had no effect on the viability of hUC-MSCs and no statistically significant difference (p>0.05) of cytotoxicity between gelatine and alginate to hUC-MSCs. Conclusion: Gelatine and alginate proved to be non-toxic to hUC-MSCs in vitro.

Co-Authors A, Maretaningtias Dwi Agus Pudijanto Bambang Agustono Bunga Shafira Eha Djulaeha K.K., Michael Josef Kevin Young Mefina Kuntjoro Rostiny Rostiny Rostiny Rostiny Sherman Salim, Sherman W, Wiwik Herawati Yunita Pratiwi

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