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All Journal Dental Journal (Majalah Kedokteran Gigi) Indonesian Journal of Prosthodontics
Nike Hendrijantini
Department Of Prosthodontic, Faculty Of Dental Medicine, Universitas Airlangga, Surabaya
Dentistry

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Journal : Indonesian Journal of Prosthodontics

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Stem Cells Approach for Implant Therapy in Diabetes Model Kuntjoro, Mefina; Hendrijantini, Nike; Agustono, Bambang; Salim, Sherman
Indonesian Journal of Prosthodontic Special Issue 2021
Publisher : Indonesia Prosthodontic Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (87.935 KB) | DOI: 10.46934/ijp.v2i0.58

Abstract

Objective of Investigation: Dental implant osseointegration in patients with hyperglycemic conditions was reported to be delayed so the restoration procedure must be postponed. Mesenchymal Stem Cells (MSCs) is a tissue engineering material that has the potential to treat various systemic diseases. Human Umbilical Cord Mesenchymal Stem Cells (hUCMSCs) is proven to improve bone microenvironment and have osteogenic potential. Their excellent capability can be a new approach for osseointegration acceleration. The purpose of this study was to determine the capability of hUCMSCs to accelerate dentalimplant osseointegration in hyperglycemic condition through angiogenesis and osteoblastogenesis. Experimental methods used: 28 Wistar rats were injected intraperitoneally with Streptozotocin 20mg/kg body weight for 5 days in a row to make the diabetic model. The treatment was carried out after fasting blood sugar levels 300 mg/dl and waited 5 days for the glycation period. The source of stem cell is human umbilical cord which has been isolated and cultured until passage 6. The experimental animals were divided into 4 groups, namely the 2-week implant group (K1), the 4-week implant group (K2), the 2-week implant + hUCMSCs group (P1) and the 4-week implant + hUCMSCs group (P2). The variables examined were BIC (Bone Implant Contact), VEGF and Runx2 expression. Data were analyzed using Analysis of Variance (ANOVA). Result : BIC, VEGF and Runx2 expresssion was higher in treatment groups compared with control groups. The highest expression of VEGF and Runx2 occurred in the P1 and decreased in the P2 group. While for BIC in groups P1 and P2 remained high to maintain osseointegration. Conclusion : With the limitation of this study, stem cells was proven to accelerate the osseointegration of dental implants through osteoblastogenesis and angiogenesis in diabetes model.
Front teeth replacement with implant-supported crowns: A case report K.K., Michael Josef; Hendrijantini, Nike; A, Maretaningtias Dwi; W, Wiwik Herawati
Indonesian Journal of Prosthodontic Vol 2, No 1 (2021): June 2021
Publisher : Indonesia Prosthodontic Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (141.351 KB) | DOI: 10.46934/ijp.v2i1.29

Abstract

The use of dental implants to support fixed or removable restoration is widely used as treatment modality. The advantages are increased retention, chewing ability, and easy access to oral hygiene procedures. A missing tooth that needs to be replaced completely can be restored using an implant-supported crown. The aim of this study is to rehabilitate maxillary partial edentulous with implant supported crown. A 56-year-old female patient came to the clinic, wanted to replace partial edentulous after extraction of 11 and 21, needed fixed restoration in order to eat and chew well, and expected high aesthetic result as well. This patient had experienced using removable partial denture to replace her lost teeth . Patient wanted to have implant treatment with fixed restoration because she felt that her partial denture did not fit anymore, so the prosthodontic treatment option was using implant-supported crowns. Implant supported crown can be an option to replace partial edentulous.
Co-Authors A, Maretaningtias Dwi Agus Pudijanto Bambang Agustono Bunga Shafira Eha Djulaeha K.K., Michael Josef Kevin Young Mefina Kuntjoro Rostiny Rostiny Rostiny Rostiny Sherman Salim, Sherman W, Wiwik Herawati Yunita Pratiwi