Agnes Frethernety
Departemen Farmakoterapi, Fakultas Kedokteran, Universitas Palangka Raya, Palangka Raya, Kalimantan Tengah, Indonesia

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Uji aktivitas antihiperglikemia ekstrak batang Uncaria gambir (W.Hunter) Roxb. pada tikus diabetes Francisca Diana Alexandra; Agnes Frethernety; Winney Amiani; Reza Nathasya Aprelea
Jurnal Kedokteran Universitas Palangka Raya Vol 11 No 1 (2023): Jurnal Kedokteran Universitas Palangka Raya
Publisher : Fakultas Kedokteran, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/jkupr.v11i1.8577

Abstract

This study aimed to prove the antihyperglycemic activity of the ethanol extract of bajakah Tampala stem (Uncaria gambir (W.Hunter) Roxb.) in rats induced by streptozotocin. The research was conducted experimentally using a true experiment posttest-only control group design. bajakah Tampala extract was extracted by maceration method using 96% ethanol solvent. The extract was made at 50mg/kgBB, 75mg/KgBB, and 100mg/KgBB in diabetic rats. The decrease in blood glucose levels of the negative control (27.27%) in this treatment was lower than that of glibenclamide (35.12%). The most significant decrease in blood glucose levels was achieved by 100 mg/kg BW, which was 44.85%. The treatment of Bajakah ethanol extract at various dose levels at the end of the observation showed a decrease in blood glucose levels but was not significantly different (p > 0.05). The results of this study did not show a significantly different decrease in blood glucose levels.    
Hubungan kebiasaan makan dan stres terhadap dispepsia mahasiswa kedokteran Universitas Palangka Raya Anggie Larasaty; Agnes Frethernety; Dian Mutiasari
Barigas: Jurnal Riset Mahasiswa Vol. 1 No. 3 (2023): Barigas: Jurnal Riset Mahasiswa
Publisher : Fakultas Kedokteran Universitas Palangka Raya

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Abstract

Dyspepsia is gastrointestinal tract syndrome, common symptom of dyspepsia is heartburn. Eating habits and stress are among risk factors for dyspepsia. This study aims to determine relationship of eating habits and stress to dyspepsia in medical students, Palangka Raya University. This study is observational analytic with cross-sectional design. Sampling using simple random sampling. The results of the study in 100 respondents found 27 people with dyspepsia and 73 people who do not; 56 people with good eating habits and 44 with bad eating habits; 9 people with mild stress, 83 people with moderate stress, and 8 people with severe stress. This study used chi-square and fisher-exact test, the results there is no relationship between eating habits and dyspepsia (p-value 0.778 >α 0.10); there is no relationship between stress and dyspepsia (p-value 1.00 >α 0.10). This shows that there is no relationship between eating habits and stress to dyspepsia.
Gambaran berat badan dan kadar HBA1C pada tikus wistar (Rattus norvegicus) model diabetes melitus tipe 2 yang diinduksi streptozotocin dan sukrosa Daniel Setyawan Saha; Agnes Frethernety; Ni Nyoman Sri Yuliani
Barigas: Jurnal Riset Mahasiswa Vol. 1 No. 3 (2023): Barigas: Jurnal Riset Mahasiswa
Publisher : Fakultas Kedokteran Universitas Palangka Raya

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Abstract

The incidence of people with diabetes mellitus (DM) continues to increase over time. The World Health Organization (WHO) predicts a substantial increase in the number of people with Type 2 diabetes mellitus in the coming years. Patients with diabetes mellitus should be able to control their weight and blood glucose levels to reduce the risk of complications by performing glycemic control examinations such as HbA1c examination and managing a healthier lifestyle and regular exercise. The method used is true experimental design with the design used in this study is pre-posttest control group design to see the average weight and HbA1c levels of wistar rats before and after treatment. This study was divided into 2 research groups consisting of Normal group (KN), rats without streptozotocin induction and treatment group (KP), rats induced by streptozotocin that have met the inclusion and exclusion criteria. The conclusion of this study is that there is an increase in body weight and HbA1c levels in mice induced streptozotocin.