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All Journal Universa Medicina Cermin Dunia Kedokteran
Melda Deliana, Melda
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Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Additional probiotic therapy lowers SCORAD index in children with atopic dermatitis Ekaputri, Jessica; Evalina, Rita; Deliana, Melda
Universa Medicina Vol 35, No 2 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.68-74

Abstract

Background Atopic dermatitis (AD) is a common skin disease that is usually chronic, relapsing, causing pruritus and frequent in children. The pathogenesis of AD involves genetic, immunological and environmental factors causing skin barrier dysfunction and dysregulation of the immune system. Probiotic treatment has been claimed to offer several functional properties including stimulation of the immune system and plays an important role in AD. The objective of this study was to evaluate the effect of probiotic therapy on atopic dermatitis in children.Methods A randomized controlled trial was conducted on 62 children suffering from AD from December 2015 to January 2016. AD severity was assessed based on the scoring of atopic dermatitis (SCORAD) index. Subjects were divided into two groups consisting of 32 and 30 children, the probiotic (probiotic + emollient) and control (emollient) groups, respectively. SCORAD index was re-evaluated after 2 weeks of therapy. The data was analyzed using Mann Whitney test.Results After the intervention, the mean SCORAD index in the probiotic group was significantly much lower than the control group (18.09 ± 8.59 vs 23.21 ± 8.71; p=0.001). The mean decrease in SCORAD index in the probiotic group was 40.4 %, much higher than the control group 25.2%. The number needed to treat (NNT) score of probiotic treatment was 5.3.Conclusion The addition of probiotics to conventional therapy effectively lowers SCORAD index by 40.4% in atopic dermatitis. The impact of probiotics on SCORAD indices is thought to be attained by modification of the immunogenicity of potential allergens.
Pengaruh Stres Psikologis terhadap Kadar Testosteron Saliva Anak Masa Pubertas Bagus Prastyo, Dimas; Deliana, Melda; Mayasari Lubis, Siska; Sugih Arto, Karina
Cermin Dunia Kedokteran Vol 45, No 4 (2018): Cidera Kepala
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v45i4.665

Abstract

Pubertas merupakan tahap penting proses tumbuh kembang anak yang merupakan sebuah proses biologis kompleks perkembangan maturasi seksual. Proses tersebut dipengaruhi oleh faktor genetik dan lingkungan, salah satunya stres. Kondisi stres akan mengganggu sistem reproduksi. Penelitian menemukan bahwa kadar testosteron dipengaruhi oleh stres. Pengukuran kadar testosteron melalui saliva tidak invasif dan hasilnya serupa dengan kadar testosteron bebas dalam serum. Pengukuran kadar testosteron saliva dapat menggambarkan pengaruh stres terhadap aksis HPG pada anak masa pubertas.Puberty is an important stage in the child's development; it is a complex biological process of sexual maturation. The process is influenced by genetic and environmental factors, like stress. Stress conditions can disrupt the reproductive system. Studies found that testosterone levels are affected by stress. Measurement of testosterone levels through saliva is not invasive and correlate with serum free testosterone levels. Salivary testosterone levels can potrays the effect of stress on the HPG axis during puberty.
Kontrol Metabolik pada Diabetes Melitus Tipe-1 Adelita, Miranda; Arto, Karina Sugih; Deliana, Melda
Cermin Dunia Kedokteran Vol 47, No 3 (2020): Dermatologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (725.968 KB) | DOI: 10.55175/cdk.v47i3.377

Abstract

Diabetes Mellitus (DM) tipe-1 adalah kondisi yang disebabkan kerusakan sel-β pankreas baik oleh proses autoimun ataupun idiopatik sehingga produksi insulin berkurang atau berhenti. DM tipe-1 sampai saat ini belum dapat disembuhkan tetapi kualitas pertumbuhan dan perkembangan anak dan remaja dapat dipertahankan seoptimal mungkin dengan upaya kontrol metabolik dengan baik. Untuk tujuan tersebut, diperlukan komponen pengelolaan DM tipe-1 yang terdiri dari lima pilar terintegrasi meliputi pemberian insulin, nutrisi, olahraga, dan edukasi didukung oleh pemantauan mandiri. Kontrol metabolik yang baik adalah mengusahakan kadar glukosa darah berada dalam batas normal atau mendekati nilai normal, tanpa menyebabkan hipoglikemia dengantarget kontrol HbA1c <7%.Type-1 Diabetes Mellitus (DM) is a condition caused by pancreatic β-cell damage either by an autoimmune or idiopathic process resulting reduced or stopped insulin production. Type-1 DM can not be cured yet but the quality of growth and development of children and adolescents can be maintained optimally by metabolic control. These goals and objectives can be achieved through type-1 DM management that consists of integrated five pillars including insulin, nutrition, exercise, education and supported by independent monitoring. Good metabolic control is to keep blood glucose levels within normal limits or close to normal values, without causing hypoglycemia. HbA1c <7% is a target of good metabolic control.
Co-Authors Adelita, Miranda Arto, Karina Sugih Bagus Prastyo, Dimas Jessica Ekaputri, Jessica Mayasari Lubis, Siska Rita Evalina Sugih Arto, Karina