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All Journal JURNAL WIDYA MEDIKA Journal Of Widya Medika Junior
Sianty Dewi
Department of Obstetrics and gynecology, Faculty of Medicine, Widya Mandala Surabaya Catholic University
Medicine & Pharmacology Public Health

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HYPOGLYCEMIC, ANTI-INFLAMMATORY EFFECT OF PORANG (AMORPHOPHALLUS ONCHOPYLLUS) ON ALLOXAN-INDUCED DIABETIC RATS Andre Young; Bernadette Dian Novita; Evan Ricardo; I.G.A.P.D Dewi; Jovan Amadeo; Sianty Dewi; Paul Tahalele
JURNAL WIDYA MEDIKA Vol 9, No 1 (2023): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v9i1.4173

Abstract

Introduction: Iles-iles / Porang is a tuber-producing plant that is commonly found in Indonesia. One of the most sought after content from Porang is Glucomannan. One of Porang’s health benefit is related to the effect of lowering blood glucose levels because it can prevent glucose absorption. These benefit is interesting to study because there has been no research linking the use of Porang to reduce inflammatory process in hyperglycmic conditions. Purpose: This study aims to analyze the anti-inflammatory, anti-oxidant and hypoglycemis effects of Glucomannan from Porang (Amorphophallus onchophyllus) extract in experimental animals. Method: The research design was a true experimental post-test only control group with random sampling to determine 5 white rats into the normal group, positive control group, negative control group and treatment 1, 2 and 3. The positive control group received Acarbose therapy thile the negative control group received carboxy-methyl-cellulose (CMC) therapy. This study used Porang extract (Amorphophallus onchophyllus) with concentrations of 200, 400 and 800 mg/Kg in hyperglycemic white rats that had been induced by Aloxan. The study was conducte for 50 days and then blood and serum samples were taken to assess the effect of hypoglycemia, anti-inflammatory and anti-oxidant using blood glucose, Malondialdehyde and C-reactiveprotein (CRP) measurement. Result and Discussion: The results showed no significant difference between the groups of rats receiving Porang extract and the positive and negative control groups. However, the MDA levels after 50 days of intervention between the negative control group and the therapy with doses of 200, 400 and 800 mg/Kg showed significant differences. Similarly found for blood glucose levels after intervention between negative control group and the 200 and 400 mg/Kg therapy group. This results may be caused by the type of Porang used, the form of the Porang and the concentration level of the Porang extract. Conclusion: Porang with the type of Amorphophallus onchophyllus can’t be used directly, but requires further processing to obtain the active substance Glucomannan.
LITERATURE STUDY: CORRELATION NUTRITION STATUS WITH WOUND HEALING Nova Mayasari; Oscar Indra Kusuma; Sianty Dewi
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 5, No 2 (2023): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v5i2.3684

Abstract

Background: Perineal rupture is the most common complication of vaginal delivery. Similar to the wound healing process in general, the perineal wound healing process is influenced by nutritional factors. Nutritional factors that are known to be related to the wound healing process are protein levels which are reflected in albumin levels. In Indonesia, serum protein levels are not a variable that is routinely monitored in pregnant women. With a high prevalence of perineal wounds, measurement of serum albumin levels can be a means of early detection of maternal nutritional factors that can affect wound healing outcomes.Objective  of this study was to determine the relationship between serum albumin levels and the degree of post-salary perineal wound healingMethods: The study was originally a prospective analytic observational study with a cross-sectional design. In response to the pandemic, the research design was changed to a literature study by searching for scientific publications during the last 5 years in Pubmed, Google Scholar, Sciencedirect, Researchgate, and Mendeley with the keywords Perineum, wounds, postpartum, albumin, nutrition and exclusion for literature studies. is inaccessible PDF and Publication not in the last 10 years .Results: There were 10 literatures regarding wound healing and nutritional status of which 6 literatures were perineal wounds and 4 literatures were wounds related to malignancy. From the literature, it was concluded as many as 10 literatures showed that there was a relationship between nutritional status and wound healing.Conclusion: : After reviewing the ten literatures, it can be concluded that there is a relationship between nutritional status and wound healing in mothers with perineal wounds.Keywords: Perineum, wound, postpartum, albumin, nutrition  
Co-Authors Andre Young Bernadette Dian Novita Evan Ricardo I.G.A.P.D Dewi Jovan Amadeo Nova Mayasari Oscar Indra Kusuma Paul Tahalele