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All Journal JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Esti Hendradi
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia
Chemistry Education Health Professions Medicine & Pharmacology Other

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Study of Growth Curve of Lactobacillus plantarum FNCC 0026 and Its Antibacterial Activity Safarini Marwah; Achmad Toto Poernomo; Esti Hendradi
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 10 No. 1 (2023): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v10i12023.38-43

Abstract

Background: Lactobacillus plantarum is one of the lactic acid bacteria (LAB) with strong antibacterial activity. However, these bacteria show different growth for each strain. The turbidimetric bacterial growth curve approach is the most accurate, fastest, and most reproducible method for obtaining an overview of the bacterial life cycle. In addition, we also examined the antibacterial activity of each observation of the growth curve. Objective: The aim of the study was to determine the optimal incubation time with the highest biomass concentration and antibacterial activity of the Lactobacillus plantarum FNCC 0026. Method: Observations of optical density (OD) values ​​were performed simultaneously on 10 points of Lactobacillus plantarum FNCC 0026 and performed every 12 hours. Antibacterial activity tested against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 8739. Result: The Lactobacillus plantarum FNCC 0026 fermentation broth showed the highest OD value and antibacterial activity after 30 hours of incubation. The maximum diameter of the inhibition zone against Staphylococcus aureus ATCC 25923 and Escherichia coli 25923 were 17.08 ± 0.51 mm and 16.83 ± 0.54 mm. Conclusion: The results showed that the antibacterial activity had a linear relationship with the concentration of bacteria. In the Lactobacillus plantarum FNCC 0026, the optimum cultivation time is in the lag phase (24 – 30 hours).
The Effect of Chitosan and Polyvinyl Alcohol Combination on Physical Characteristics and Mechanical Properties of Chitosan-PVA-Aloe vera Film Dioni fadia Zatalini; Esti Hendradi; Philip Drake; Retno Sari
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 10 No. 2 (2023): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v10i22023.151-161

Abstract

Background: Wound is a condition where there is damage or disruption to the anatomical structure and function of the skin. Wounds that are not treated properly can lead to infection. As wound dressings, film dressings have many advantages such as being elastic, flexible, transparent, and can adapt to the wound shape. Film’s characteristics of are affected by the plasticizer and the polymer. Combination of chitosan and polyvinyl alcohol (PVA)  is able to improve the mechanical properties of the film such as its swelling capacity, tensile strength, and elongation at break. Objective: This study aims to determine the effects of chitosan and PVA in various concentrations on the physical characteristics and mechanical properties of the film. Methods: Film was prepared by solvent casting method, using chitosan and alginate in various concentrations of 0% to 1.5%, 1.5% Aloe vera, and 6% propylene glycol. Films’ characteristics and mechanical properties were evaluated, such as swelling index, tensile strength, elongation at break, and Young’s modulus. Results: The result showed that chitosan and PVA polymers had a significant effect on the swelling index, tensile strength, elongation at break, and Young’s modulus. The effect of chitosan and PVA combination on the swelling index, tensile strength, and elongation at break is due to the hydrogen bonding between the hydroxyl group of PVA and the amine group of chitosan. Conclusion: The combination of chitosan and polyvinyl alcohol influenced the film's physical and mechanical properties. Film with chitosan and polyvinyl alcohol ratio of 1.5%:1.5% have best characteristics compared to others.
Co-Authors Achmad Toto Poernomo Dioni fadia Zatalini Philip Drake Retno Sari Safarini Marwah