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All Journal Jambura Journal of Health Sciences and Research Mejuajua Jurnal Indah Sains dan Klinis
Muharni Saputri
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Humanities Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Other

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EFFECTIVENESS OF BUTTERFLY PEA ETHANOL EXTRACT ON DECREASING BLOOD GLUCOSE LEVELS OF MALE MICE Erica Mega Valentine Simangunsong; Yessi Febriani; Muharni Saputri; Dina Arisa; Ghianti Zarqa Afifah
Jambura Journal of Health Sciences and Research Vol 5, No 2 (2023): APRIL: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v5i2.18789

Abstract

Butterfly pea flower (Clitoria Ternatea L.) contains flavonoids, tannins, and triterpenoids, which contain flavonoid compounds that have the potential as antioxidants. Antioxidants can suppress beta cell apoptosis without changing the proliferation of pancreatic beta cells. Antioxidants can bind free radicals so that they can reduce insulin resistance. The novelty of this study was that it examined the effectiveness of ethanol extract from butterfly pea flowers on reducing alloxan-induced male mice blood glucose levels. This study aimed to determine the effectiveness of the ethanol extract of butterfly pea flowers in reducing alloxan-induced blood glucose levels. The study used an experimental method with 5 treatments on 25 mice, beginning with purposive collection and processing of sample plants, preparation of Simplicia powder, preparation of ethanol extract of butterfly pea flowers, characteristic testing, determination of total ash content, determination of acid insoluble ash content, determination of extract content. Soluble in water, determination of ethanol soluble extract content, determination of water content, phytochemical screening, testing of antidiabetic activity of butterfly pea flower extract induced by alloxan. The examination results contained a total ash content of 5.20%, an acid-insoluble ash content of 1.16%, a water-soluble essence content of 47.94%, and a water content of 3.29%. The results of the compounds in the ethanol extract of butterfly pea flowers are alkaloids, flavonoids, tannins, saponins, and steroids. The results of testing blood glucose levels of ethanol extract of butterfly pea flower (EEBT) at a dose of 200mg/kg bb were known to be effective in reducing blood glucose after being induced by alloxan 150mg/kg bb with glucose levels of 319mg/dL dropping to 104.93mg/dL. The conclusion of the ethanol extract of the butterfly pea flower shows that the butterfly pea flower is efficacious as a blood glucose lowering agent in alloxan-induced mice (Mus musculus).
Edukasi Pencegahan Penyakit Diabetes Menggunakan Obat Herbal di Lingkungan Pengajian Mesjid Namira Medan Muflihah Fujiko; Muharni Saputri; Ginting, Ernawaty; Fanny Rizki; Tambunan, Pravil Mistriyanto
Mejuajua: Jurnal Pengabdian pada Masyarakat Vol. 4 No. 1 (2024): Agustus 2024
Publisher : Yayasan Penelitian dan Inovasi Sumatera (YPIS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/mejuajuajabdimas.v4i1.156

Abstract

Diabetes merupakan salah satu penyakit kronis yang ditandai dengan terjadinya peningkatan gula dalam darah yang dapat menyebabkan kerusakan serius pada jantung, pembuluh darah, mata, ginjal dan saraf. Pengobatan diabetes saat ini banyak dilakukan dengan menggunakan obat-obatan alami dari bahan alam, diantaranya adalah jahe, kulit kayu manis, pare, daun sambung nyawa, daun tapak dara, dan daun mimba. Banyak masyarakat yang belum mengetahui manfaat dari penggunaan bahan alam tersebut sehingga perlu dilakukan edukasi dengan melakukan penyuluhan kepada masyarakat. Metode yang dilakukan adalah melalui presentasi. Hasil kegiatan ini bertujuan meningkatkan pengetahuan masyarakat terkait penggunaan bahan alam sebagai terapi pencegahan penyakit diabetes
Efek Antihiperlipidemia Kombucha Daun Kari (Murraya koenigii (L.) Spreng) pada Tikus Putih Jantan (Rattus norvegicus) yang Diinduksi Dengan High Fat dan PTU Hardyanto Napitupulu,; Muharni Saputri; Salmah Handayani Lubis; Muflihah Fujiko; Ernawaty Ginting
Jurnal Indah Sains dan Klinis Vol 2 No 3 (2021): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/7xzsgc35

Abstract

Curry leaves (Murraya koenigii (L.) Spreng) is a plant that is often used in cooking spices that are high in fat because curry leaves contain secondary metabolite compounds such asalkaloids, glycosides, and flavonoids that serve to inhibit the growth of free radicals and lower cholesterol levels. Generally curry leaves are processed traditionally in a simple form, while research will process curry leaves in the form of fermented beverages in the form of kombucha tea. This study aims to explore the process of making curry leaf kombucha tea and know the antihiperlipidemia effect. This research is descriptive and experimental, including material collection, simplisia making, phytochemical screening, fermentation of curry leaf kombucha, evaluation of dosage quality, testing of triglyceride levels in rats with Electrode-Based Biosensor technique. The mice used in this study were 25 and divided into 5 test groups. K1 (negative blank), K2 (Simvastatin), K3 (dose 100 ml), K4 (dose 150 ml), K5 (dose 200 ml) induced using 80% egg yolk and PTU 0.2%. The results showed that the quality evaluation of kombucha tea gave good results to pH 3.08-3.44 and did not experience changes in taste and smell. In the group of 5 doses of 200 ml with kombucha tea administration on the 7th to 15th day, it was shown that cholesterol levels decreased from 253.0 mg/dL to 92.2 ml/dL where these results were close to comparing (simvastatin) from 247.8 mg/dL to 79.2 mg/dL
Co-Authors Dina Arisa Erica Mega Valentine Simangunsong Ernawaty Ginting Fanny Rizki Ghianti Zarqa Afifah Ginting, Ernawaty Hardyanto Napitupulu, Muflihah Fujiko Salmah Handayani Lubis Tambunan, Pravil Mistriyanto Yessi Febriani