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All Journal Jurnal Ilmiah Bakti Farmasi Jurnal Ilmiah Kesehatan Delima Parapemikir Jurnal Ilmiah Farmasi
Eva Kholifah
STIKes Salsabila Serang
Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health

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Literature Review: Mekanisme Kerja Obat Antidislipidemia Baha Udin; Eva Kholifah
Jurnal Ilmiah Bakti Farmasi Vol 6 No 1 (2021): Jurnal Ilmiah Bhakti Farmasi
Publisher : Lembaga Penelitian & Pengabdian Kepada Masyarakat (LPPM) STIFI Bhakti Pertiwi Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61685/jibf.v6i1.75

Abstract

Dislipidemia merupakan kondisi tubuh manusia yang memiliki kadar lipid yang abnormal. Penggunaan obat merupakan salah satu metode yang ideal untuk menangani pasien dislipidemia. Saat ini, terdapat cukup bervariasi golongan obat yang digunakan untuk mengatasi dislipidemia dengan memiliki mekanisme kerja nya masing-masing. Berdasarkan mekanisme kerja obat antidislipidemia saat ini terdapat tujuh golongan, seperti golongan statin, fibrat dan derivatnya, bile acid sequestrants (bass), ezetimibe, asam nikotinik dan derivatnya, PCSK9 inhibitor, asam lemak omega-3. Terdapat perbedaan target dan mekanisme kerja suatu golongan obat.
Optimasi Formula Tablet Black Garlic Menggunakan Kombinasi Laktosa dan Avicel Ph 102 dengan Metode Simplex Lattice Design Siti Lailatu Zahroh; Sofi Nurmay Stiani; Eva Kholifah
Jurnal Ilmiah Kesehatan Delima Vol. 5 No. 2 (2023): Jurnal Ilmiah Kesehatan Delima
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Sekolah Tinggi Ilmu Kesehatan Salsabila Serang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60010/jikd.v5i2.95

Abstract

The study aims to find out whether the combination of lactose and avicel pH 102 can be formulated into black garlic extract tablet in accordance with the Indonesian Pharmacopoeia, the influence of combination, and determine the optimum formulation of the two ingredients using the SLD method. Methods used in this research Black Garlic extract is made by maceration method with 96% ethanol solvent with an extract weight of each tablet of 400 mg. Black garlic extract tablets are made in three formulations with a ratio of lactose-avicel PH-102, namely FI (100%:0%), FII (50%:50%), and FIII (0%:100%). Result shows that the optimum formula obtained was 80% lactose and 20% avicel PH 102 with a total predicted value of 0.645. The greater the concentration of avicel PH 102 as a crushing material, the faster the time rate of destruction, the hardness decreases, and the fragility value rises. The higher the concentration of the filler, the longer the crushing time it will take. The results of the statistical analysis of the three formulas tested showed the absence of significant differences between flow time, hardness, and brittleness, while crushed time tests showed the presence of significant differences (p?0.05). Tujuan penelitian ini adalah kombinasi antara laktosa dan avicel pH 102 dapat diformulasikan menjadi sediaan tablet sesuai dengan Farmakope Indonesia, pengaruh tehadap kombinasi dan penentuan formulasi yang optimum dari kedua bahan tersebut dapat dilakukan dengan metode SLD. Metode dalam penelitian ini adalah Ekstrak Black Garlic dibuat dengan metode maserasi dengan pelarut etanol 96% dengan bobot ekstrak setiap tablet 400 mg. Tablet ekstrak black garlic dibuat tiga formulasi dengan perbandingan laktosa-avicel PH-102 yaitu FI (100%:0%), FII (50%:50%) dan FIII (0%:100%). Hasil penelitian menunjukkan bahwa formula optimum yang diperoleh adalah 80% laktosa dan 20% avicel PH 102 dengan total nilai prediksi 0.645. Semakin besar konsentrasi avicel PH 102 sebagai bahan penghancur, maka tingkat waktu hancur semakin cepat, kekerasan semakin turun, nilai kerapuhan semakin naik. Semakin tinggi konsentrasi pengisi, maka semakin lama waktu hancur yang dibutuhkan. Hasil analisis statistik dari ketiga formula yang diuji menunjukkan tidak adanya perbedaan yang signifikan antara waktu alir, kekerasan dan kerapuhan, sedangkan untuk uji waktu hancur menunjukkan adanya perbedaan yang signifikan (p?0.05).
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK TELUR KEONG MAS (Pomacea canaliculata) DENGAN METODE DPPH (2,2-DIFENIL-1-PIKRILHIDRAZIL) MENGGUNAKAN SPEKTROFOTOMETRI UV-VIS Eva Kholifah
Parapemikir : Jurnal Ilmiah Farmasi Vol 12, No 3 (2023): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v12i3.4817

Abstract

Antioxidant are compound that could donate one or more electron to free radical to inhibit free radical reaction. One of the mollusc that has the potential to be an antioxidant is the egg of the gold snail (Pomacea canaliculata). The purpose of this study was to determine the antioxidant activity of gold snail egg. Testing of antioxidant activity was carried out by the DPPH (2,2-diphenyl-1-picrilhydrazyl) method. Gold snail egg are macerated with a mixture of solvent acetone:methanol (1:8). The extract which had been vaporized, was tested its phytochemical compound with phytochemical screening test, the results of the phytochemical screening of the extract showed positive contain alkaloid, flavonoid, steroid, triterpenoid, saponin, and protein. The gold snail egg extract was then tested for its antioxidant activity quantitatively to obtain IC50 (Inhibitory Concentration) values from the extract using UV-Vis spectrophotometry at a wavelength (λmax) of 515 nm with vitamin C as a positive control. The results of spectrophotometric measurements show that gold snail egg extract has an IC50 value of 4,890 μg / ml and vitamin C has an IC50 value of 2,792 μg / ml. According to the result, it can be concluded that antioxidant activity of golden snail egg extract is lower than vitamin C but still potential as an antioxidant.
Co-Authors Baha Udin Siti Lailatu Zahroh Stiani, Sofi Nurmay