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All Journal International Journal of Integrated Health Sciences
Endin Nokik Stujanna
Faculty of Medicine, Universitas Muhammadiyah Prof. DR. HAMKA
Health Professions

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Journal : International Journal of Integrated Health Sciences

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Sedative Effects of Intraperitoneal Diazepam in Mice Marsha Vania; Shinta Dewi Permata Sari; Bambang Siswitono; Endin Nokik Stujanna
International Journal of Integrated Health Sciences Vol 11, No 1 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Objectives: To determine the effectiveness of Diazepam in comparison with Phenobarbital.Methods: Twenty-seven male Swiss Webster mice were used and randomly divided into three groups of negative control (NS), positive control (Phenobarbital), and diazepam group. Two tests were performed on these group: the traction Test and the Fireplace Test. Pupillary diameter was also observed.Results: A significant difference based on the Kruskal - Wallis statistical test was observed between the positive control and the diazepam group (<0.05) in the traction test, which was also true for the fireplaced test (p<0.05). The pupillary diameter in the test animals in the positive control and diazepam group was not statistically significant (p>0.05).Conclusion: Diazepam has a better sedative effect than Phenobarbital. The sedative effect produced by Diazepam is stronger, with faster onset and longer half-life than the Phenobarbital the positive control. However, different test methods and comparisons should be sought to support this conclusion.
Co-Authors Bambang Siswitono Marsha Vania Shinta Dewi Permata Sari