Article Per Year (5 Year)
p-Index From 2019 - 2024
0
P-Index
This Author published in this journals
All Journal Dentika Dental Journal Padjadjaran Journal of Dentistry
Eriyati Darwin, Eriyati
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
The difference of matrix metalloproteinase-9 level in saliva between myofascial pain and disc displacement of temporomandibular joint disorders Rafni, Elita; Y., Yanwirasti; Darwin, Eriyati; Rikmasari, Rasmi
Padjadjaran Journal of Dentistry Vol 29, No 2 (2017): July
Publisher : Faculty of Dentistry Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (187.402 KB) | DOI: 10.24198/pjd.vol29no2.13613

Abstract

Introduction: Saliva is the type of liquid which contains enzyme, hormone, antibody, constituent microbe, and cytokines. Matrix metalloproteinase-9 (MMP-9) is one kind of proteolysis cellular enzyme in saliva that has a role in inflammation. Saliva is very easy to take and noninvasive treatment, proved efficient for early diagnosis. The purpose of this research was to study the difference MMP-9 level in saliva patient with temporomandibular joint disorders between myofascial pain and disc displacement. Methods: Cross sectional comparative study. The research was carried out at the Prosthodontics Clinic of Arifin Achmad Pekanbaru Hospital and at Biomedical Laboratory of Faculty of Medicine, Universitas Andalas Padang, Indonesia. The saliva samples were taken from 37 myofascial pain patients and 37 disc displacement patients. MMP-9 levels were examined by the Elisa and the data result was analyzed using the t-test. Result: The average value of MMP-9 level of disc displacement was 650.98±384.94 pg/mL and myofascial pain was 168.70±41.24 pg/mL. There was a significant difference on MMP-9 level in saliva between myofascial pain and disc displacement (p<0.05). Conclusion: The MMP-9 level in saliva of patients with disc displacement of temporomandibular joint disorders was higher than patients with myofascial pain.
PERBEDAAN KADAR INTERLEUKIN-1β SALIVA ANTARA PENDERITA MYOFASCIAL PAIN DENGAN DISC DISPLACEMENT SENDI TEMPOROMANDIBULA Rafni, Elita; Yanwirasti, Yanwirasti; Darwin, Eriyati; Rikmasari, Rasmi
Dentika: Dental Journal Vol. 19 No. 1 (2016): Dentika Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (204.714 KB) | DOI: 10.32734/dentika.v19i1.152

Abstract

Gangguan sendi temporomandibula dapat terjadi karena peradangan neurogenik yang banyak melibatkan sitokin. Pada penderita gangguan sendi temporomandibula dengan keluhan nyeri ditemukan adanya substansi algogenik prostaglandin dan lukotrien sebagai mediator nyeri dan inflamasi. Prostaglandin berasal dari asam arakidonat yang berubah menjadi PGE2 karena aktivitas Cox2 yang diinduksi oleh sitokin IL-1β. Saliva merupakan cairan yang mengandung hormon, antibodi, konstituent mikroba, dan sitokin seperti yang terdapat dalam darah. Penelitian ini dilakukan untuk melihat perbedaan kadar IL-1β pada penderita myofascial pain dan disc displacement sendi temporomandibula. Penelitian ini menggunakan metode cross sectional comparative. Variabel dependen dan independen diperiksa secara bersamaan. Penelitian ini dilakukan di Poliklinik Prostodonsia Rumah Sakit Arifin Ahmad Pekanbaru dan Laboratorium Biomedik Fakultas Kedokteran Universitas Andalas Padang. Pemeriksaan sampel saliva dilakukan pada 37 penderita myofascial pain dan 37 penderita disc displacement. Kadar IL-1β diperiksa dengan Elisa dan data dianalisis dengan t test. Berdasarkan uji statistik Kolmogorov Smirnov ditemukan bahwa data terdistribusi normal baik pada kelompok gender (p =0,772) maupun kelompok umur (p =1,000). Rerata nilai kadar IL-1β penderita myofascial pain adalah 0,22 ± 0,18 nm/L dan penderita disc displacement adalah 0,57 ± 0,45 nm/L. Hasil analisis t-test menunjukkan terdapat perbedaan kadar IL-1β saliva yang signifikan antara penderita myofascial pain dan disc displacement p =0,01 (p<0,05). Sebagai kesimpulan bahwa kadar IL-1β lebih tinggi pada disc displacement dibandingkan myofascial pain.
Co-Authors Elita Rafni, Elita Rasmi Rikmasari Yanwirasti Y., Yanwirasti Yanwirasti Yanwirasti