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Sutriyo Sutriyo, Sutriyo
Departemen Farmasi FMIPA-UI Depok

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Pengaruh Polivinil Pirolidon Terhadap Laju Disolusi Furosemid Dalam Sistem Dispersi Padat Sutriyo, Sutriyo; Dewi, Rosmala; Filosane, Febrian Hevike
Majalah Ilmu Kefarmasian Vol. 2, No. 1
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The research to accelerate furosemide dissolution rate has been done through physical property modification by solid dispersion forming polyvinylpyrolidone (PVP) carrier with solvent method. Pure furosemide posses property of being practically insoluble in water and has low bioavailability. In current research, six weight ratio of furosemide to PVP being used are 1:1; 1:3; 1:5; 1:9 and 1:15. Physical mixtures are made in equivalent weight ratio. The dissolution rate was examined by paddle method in phosphat buffer pH 5,8. Solid dispersion caracterised with in vitro dissolution study, X-ray diffraction, infra red spectrophotometer and differential scanning calorimetric. The result shows that solid dispersion of furosemide with PVP carrier is higher compare to physical mixture dissolution rate and pure furosemide. The ratio furosemide to PVP who has the highest dissolution rate is 1:15. The analyzing shows the existing of altering crystalline to amorphous state.
Perbandingan Pelepasan Propranolol Hidroklorida Dari Matriks Kitosan, Etil Selulosa (EC) Dan Hidroksi Propil Metil Selulosa (HPMC) Sutriyo, Sutriyo; Djajadisastra, Joshita; Indah, Rosari
Majalah Ilmu Kefarmasian Vol. 2, No. 3
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Chitosan is a polycatonic biopolymer that can form gel in acidic environment so that can be used as a hydrophilic matrix in controlled release drug delivery system. In this research, propranolol hydrochloride controlled release granule was made in chitosan matrix. Granules were made by wet granulation method with variety of matrices, i.e. chitosan, hydroxypropyl methylcellulose (HPMC) and ethyl cellulose (EC). HPMC and EC were used as a comparing matrix. The release rates of propranolol HCl from matrix were determined by using dissolution apparatus type I with 50 rpm stirring rotation in acidic media of pH 1,2 and base media of pH 7,5 for 8 hours. Sample was taken at certain time and the samples were analyzed by spectrophotometer. The result showed that the release of propranolol hydrochloride from chitosan matrix was the slowest compared to the other matrices.
Pengembangan Sediaan Dengan Pelepasan Dimodifikasi Mengandung Furosemid Sebagai Model Zat Aktif Menggunakan Sistem Mukoadhesif Sutriyo, Sutriyo; Rachmat, Hasan; Rosalina, Mita
Majalah Ilmu Kefarmasian
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Drug bioavailability is one of the parameter which is used to evaluate the effectiveness of pharmaceutical dosage form. Rate of dissolution and drug residence time in gas-trointestinal tract is a factor which can influence the bioavailability. Solid dispersion and mucoadhesive drug delivery system is one of the method which can be used to solve the problem concerning the rate of dissolution and residence time in gastrointes-tinal tract. In this research mucoadhesive microgranule had been made with furo-semide as a drug model and Carbopol 934P® as a mucoadhesive polimer. The mucoadhesive microgranules resulted from this investigation has a particle size range of 425-850 µm, and was evaluated by type 1, 100 rpm speed and phosphate buffer pH 5.8 dissolution test and by wash off test. Furosemide was made in solid dispersion with polyvinylpyrrolidone (PVP K30®) with weight ratio of 1:7 using solubility method. The results showed increasing the dissolution rate of furosemide in solid dispersion compared to pure furosemide. Increasing the concentration of Carbopol 934P® in microgranule will cause inhibition of drug release and increasing the amount of microgranule sticked to gastric and intestinal mucous.
Pengaruh Kombinasi Hidroksipropil Metilselulosa-Xanthan Gum sebagai Matriks Pada Profil Pelepasan Tablet Teofilin Lepas Terkendali Iskandarsyah, Iskandarsyah; Sutriyo, Sutriyo; Hayati, Dian
Majalah Ilmu Kefarmasian Vol. 7, No. 3
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Theophylline is a bronchodilator used for the treatment of bronchial asthma and other respiratory diseases. Theophylline has a narrow therapeutic index (10-20 µg/ml) and relatively short elimination half-life (6,19 ± 0,031 hours). Causes rapid elimination rate of theophylline should be given periodically to maintain drug levels in blood for the desired therapeutic effect can be achieved. The preparation of theophylline controlled release is expected to produce blood concentrations of theophylline in a more stable. The physical properties of tablets and drug release from matrix systems are influenced by the nature of the composition of the matrix. This research, theophylline controlled release tablets were made by combination of xanthan gum and HPMC as matrix composition. Combination of HPMC and xanthan gum was supposed to produce tablets with the required pysical properties and ability to extend the releasing period of theophylline from matrix system. HPMC-xanthan gum compositions used in formulation were 1:4, 1:1, and 4:1. Based on the evaluation of the physical properties carried out on the tablet, it was found out that the three formulas fit the requirements for ideal tablet. The increasing of xanthan gum concentration in the formula was proportional with the improvement of mass flowability and tablet hardness. Evaluation of the releasing profile of theophylline from matrix system had been conducted in vitro by dissolution test. Based on the test, it was found out that all combinations have variation in releasing profile. The increasing of HPMC concentration in formula will extend the releasing time of theophylline. The difference in releasing profile of Retaphyl SR® with formula 1, 2, and 3 because of differences in raw materials that form the matrix.
Studi Disolusi Terbanding Tablet Komparator dan Generik Glibenklamida 5 MG Menggunakan Parameter Difference Factor (f2) dan Similarity Factor (f1) Sutriyo, Sutriyo; Aeni, Siti Nur; Sundarsih, Sundarsih
Majalah Ilmu Kefarmasian Vol. 9, No. 3
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Dissolution testing is an essential requirement for the development, establishment of in Vitro dissolution and in Vivo performance (I VIV R), registration and quality control Of solid oral dosage forms. The objective of the present study was to compare dissolution profile of glibenclamide 5 mg tablet between generic and inovator product from commercial market, using independent model. Samples of glibenclamide 5 mg tablets was used on the batch number are the Same design for each other product. The dissolution test were perfoming using USP 23 apparatus 2, in pH 7,40 buffer phosphate, employing 900 ml of dissolution medium at a temperature of 37 ±0,5 ˚C and an agitation rate of 75 rpm with spesification performed at 15, 30, 45, 60 and 120 minutes. Comparison between dissolution profiles was achieved using a difference factor (f1) and simmilarity factor (f2) methods in inovator product and generic \ product. The results showed that dissolution profiles of product B (generic) has similar with product A (inovator) where difference factor (f1) value is 5,53% and simmilarity factor (f2) is 99,29 %
Mikroenkapsulasi Propanolol Hidroklorida Dengan Penyalut Etil Selulosa Menggunakan Metoda Penguapan Pelarut Sutriyo, Sutriyo; Djajadisastra, Joshita; Novitasari, Adilla
Majalah Ilmu Kefarmasian Vol. 1, No. 2
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Propranolol hydrochloride is antihypertension agent that has a short biological half life of 2-6 hours. Microcapsules of propranolol hydrochloride are prepared by solvent evaporation method using ethylcellulose as a wall material with the drug-polymer ratio 1:1, 1:2, and 1:3 for sustained release oral delivery. The microcapsules were then evaluated by particle size distribution analysis, shape and morphology (SEM), drug content, and dissolution studies. In vitro dissolution was studied using the dissolution apparatus II (paddle) with chloride buffer (pH 1,2) dan phosphate buffer (pH 6,8) medium. The drug-polymer ratio have an important influence on drug release from microcapsules where the increase of polymer cause the higher drug release inhibition.
Formulasi Sediaan Granul Mukoadhesif Kombinasi Ekstrak Kulit Batang Mimba (Azadirachta indica A. Juss) dan Kunyit (Curcuma domestica val.) Sutriyo, Sutriyo; Khairunnisya, Khairunnisya; Mun’im, Abdul
Majalah Ilmu Kefarmasian
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Neem bark (Azadirachta indica A.Juss) and turmeric (Curcuma domestica Val.) extracts have been found posses gastroprotective effect so that they are used in the treatment of gastric ulcer. Administration of combination of both extracts can give synergistic effect so that the administration dose can be reduced. In this research, combination of neem bark and turmeric extracts were formulated as mucoadhesive granules to improve their effectivenesses by increasing the residence time of dosage form in the stomach. Mucoadhesive granules were prepared by wet granulation method in six formulas using HPMC, Carbopol, and combination of HPMC and Carbopol as mucoadhesive polymers. Granules were evaluated for particle size distribution, swelling, mucoadhesive strength with bioadhesive in vitro test and wash off test, and dissolution. Bioadhesive in vitro test showed that all formulas have goodmucoadhesive strength.Wash off test showed that combination of HPMC and Carbopol can improve mucoadhesive strength of formulas. Mucoadhesive strength increased with the increasing of HPMC. The result of this research indicated that formula with combination ofHPMCand Carbopol (2:1) showed best mucoadhesive strength with percentage of mucoadhesion 98.67%in bioadhesive in vitro test and 38.00% in wash off test.
Pengembangan Sistem Penghantaran Obat Solid Self-Emulsifying Mikropartikel Gliklazid untuk Meningkatkan Disolusi Suryani, Mega; Sutriyo, Sutriyo
Majalah Ilmu Kefarmasian Vol. 8, No. 1
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Gliclazide is a Hypoglycemicdrug, second-generation sulfonylurea used in the treatment of non insulin dependent diabetes mellitus. Gliclazide exhibit poor aqueous solubility, so that their low bioavailability. Objectivesthis study is to develop solid self-emulsifying (SE) microparticles of poorly soluble gliclazide to dissolution enchancement. These microparticles were prepared by spray drying method, using three surfactant (acripol, tween 80 and sodium lauryl sulphate) with various concentration. SE microparticles characterized in terms of morphology (SEM), particle size distribution (PSA), x-ray diffraction (XRD), thermal analysis (DSC), functional group analysis (FTIR), solubility test, and dissolution test. The all gliclazide SE microparticlesexhibited particle size smaller than pure gliclazide. The dissolution rate of gliclazide SE microparticles at one hour was increased about 2 to 3 times than gliclazide.
Pengaruh Natrium Hialuronat terhadap Penetrasi Kofein Sebagai Antiselulit dalam Sediaan Hidrogel, Hidroalkoholik Gel, dan Emulsi Gel Djajadisastra, Joshita; Dzuhro, Zuraida Syafara; Sutriyo, Sutriyo
Pharmaceutical Sciences and Research
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Anticellulite topical gel preparation with caffeine as active ingredient needs a penetration enhancer to reach subcutaneous layer. Sodium hyaluronate (NaHA), the sodium salt of hyaluronic acid, is a hydrophilic polysaccharide derivative polymer. It has ability to enhance percutaneous penetration by loosening the dense of the compact substance stratum corneum. The aim of this research was to observe the effects of NaHA on caffeine penetration as anticellulite active agent in three types of gel preparation: hydrogel, hydroalcoholic gel, and gel emulsion. Each gel type contained caffeine 1,5% and was varied into three formulas. Formula 1 contained HPMC 2% as gel basis; formula 2 contained HPMC 2% and NaHA 0,5%; formula 3 contained NaHA 2% as gel basis. Caffeine penetration properties were analyzed by Franz diffusion cell in vitro test using rat skin as membrane. Percent caffeine penetration of hydrogel formula 1, 2, 3 were 9,41 ± 0,01%; 11,74 ± 0,13%; 16,32 ± 0,03%, respectively. Percent caffeine penetration of hydroalcoholic gel formula 1, 2, 3 were 19,54 ± 0,02%; 22,99 ± 0,23%; 7,42 ± 0,08%, respectively. Percent caffeine penetration of gel emulsion formula 1, 2, 3 were 10,47 ± 0,19%; 13,41 ± 0,12%; 18,42 ± 0,06%, respectively. The result showed that NaHA enhanced the caffeine percutaneous penetration properties in various gel preparations, except hidroalkoholic gel formula 3.
Co-Authors Adilla Novitasari, Adilla Dian Hayati Febrian Hevike Filosane, Febrian Hevike Hasan Rachmat, Hasan Indah, Rosari Iskandarsyah Iskandarsyah Joshita Djajadisastra, Joshita Khairunnisya, Khairunnisya Mega Suryani, Mega Mita Rosalina, Mita Mun’im, Abdul Rosmala Dewi Siti Nur Aeni, Siti Nur Sundarsih, Sundarsih Zuraida Syafara Dzuhro, Zuraida Syafara