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All Journal Jurnal Kedokteran Diponegoro
Danisa Diandra Safarina
Faculty of Medicine, Diponegoro University, Indonesia
Medicine & Pharmacology

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Post COVID-19 Immunization Herpes Zoster Reactivation In Asia : A Literature Review Nurul Nisa Ulfa; Danisa Diandra Safarina; Puguh Riyanto
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 4 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i3.37292

Abstract

Background: The COVID-19 vaccine that targets viral mRNA has been created and can be used as an effort to end the COVID-19 pandemic that has hit the world since 2020. The COVID-19 vaccine currently being developed has proven its effectiveness and safety in the general adult population.Objective: To identify reactivation of Herpes Zoster virus post COVID-19 vaccine.Methods: This article review discusses four case reports of Herpes Zoster following the COVID-19 immunization in Asia which were obtained from various sources such as Pubmed Medline Embase.Results: The mRNA-type vaccine is associated with skin manifestations with an increased incidence (14.4%) of Herpes Zoster which was observed around 6-8 days after administration of the first dose of vaccine (BNT162b2 vaccine) and 1.5% after administration of the mRNA- 1273 which occurred in the Asian Oceanian race. COVID-19 vaccine substances such as polyethylene glycol (PEG), the polysorbate present in mRNA vaccines, and polysorbate 80 are suspected causing an allergic reactions.Conclusion: Health workers must be careful in administering the COVID-19 vaccine, especially to individuals who have risk factors that can decrease their immune system so it can cause reactivation of Herpes Zoster.   
Co-Authors Nurul Nisa Ulfa Puguh Riyanto