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Aida Lydia, Aida
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Medicine & Pharmacology

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Proportion of Pre-dialysis Prolonged QT Dispersion in TwiceWeekly Chronic Hemodialysis Patients and Its Associated Factors Pattiiha, Arief; Yamin, Muhammad; Lydia, Aida; Abdullah, Murdani
Jurnal Penyakit Dalam Indonesia Vol. 8, No. 2
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Introduction. Cardiovascular disease (CVD) is the common cause of mortality in end-stage renal disease (ESRD) patients undergoing hemodialysis (HD). Causes of CVD in ESRD patients are multifactorial. Ventricular arrhythmia is known as the leading cause of sudden death in dialysis patients. QT dispersion, which is measured from electrocardiography (ECG), is known as one of the parameters to assess the risk of arrhythmia in HD patients. This study aimed to determine the proportion of pre-dialysis prolonged QT dispersion in chronic twice-weekly HD patients and the associated factors. Methods. A cross-sectional study was conducted among HD patients age ≥18 years with dialysis duration of at least three months in Cipto Mangunkusumo Hospital during May–June 2019. Electrocardiography, echocardiography, and blood samples were taken before the dialysis session. Bivariate analysis using Chi-square and Fisher’s exact test was performed on each variable. Significant results were further analysed using logistic regression. Results. A total of 142 subjects were included in this study. The mean age of subjects was 49 (standard deviation (SD) 15) years. Prolonged QT dispersion was found in 51 subjects (35.9%). Multivariate analysis showed prolonged QT dispersion was significantly correlated with systolic dysfunction (PR=1.875 (CI 95% 1.234-2.848); p=0.006) and left ventricle hypertrophy (PR=2.361 (CI 95% 1.032-5.403); p=0.019). Age, diabetes mellitus, hypokalemia, hypomagnesemia, and diastolic dysfunction were not significantly correlated with QT dispersion (p>0.05). Conclusion. The proportion of pre-dialysis prolonged QT dispersion in twice-weekly chronic hemodialysis patients in RSCM is 35.9% and associated with systolic dysfunction and left ventricle hypertrophy
The Role of Continous Ambulatory Peritoneal Dialysis in Equity of Kidney Replacement Therapy in Indonesia Lydia, Aida
Jurnal Penyakit Dalam Indonesia Vol. 7, No. 3
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With the increasing incidence of chronic kidney disease in Indonesia, an effective, sustainable and widely available kidney replacement therapy (KRT) is needed. PD is one of the available modalities that can meet those criteria. To date, out of the two existing types of PD, only continuous ambulatory peritoneal dialysis (CAPD) is available in our country. Studies showed that residual kidney function is preserved better in CAPD patients compared to HD patients. With the use of CAPD as KRT, patients can do dialysis independently. Hence, it can be solution to the limitations and the difficulty of reaching HD units especially in remote areas. However, due to lack of knowledge or experience of clinicians regarding CAPD, the use of CAPD is scarce in Indonesia. Clinicians can increase their role in kidney services by increasing CAPD utilization. The key to improve CAPD utilization is a good understanding and optimal education about CAPD to patients and their families. This review aims to introduce and remind clinicians of the availability of CAPD besides HD and kidney transplant as one of the available modalities of KRT for patients with ESKD in Indonesia.
Factors Associated with Late Referral in End Stage Renal Disease Patients at Dr. Cipto Mangunkusumo Hospital Lydia, Aida; Rachmaningrum, Grecia; Shatri, Hamzah; Nugroho, Pringgodigdo
Jurnal Penyakit Dalam Indonesia Vol. 7, No. 2
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Effect of Structured Education and Antihypertensive MedicationsAdherence to Decrease Blood Pressure for Hypertension inElderly: a Randomized Controlled Trial Khomaini, Ayatullah; Setiati, Siti; Lydia, Aida; Dewiasty, Esthika
Jurnal Penyakit Dalam Indonesia Vol. 4, No. 1
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Introduction. Hypertension is one of the important problems in elderly due to high impact of cardiovascular complications. Education and antihypertensive medication adherence are considered as influence factors in a holistic and comprehensive hypertension treatment. This study was conducted to determine the effect of structured education and antihypertensive medication adherence in decreasing blood pressure as part of the hypertension treatment in elderly patients. Methods. A randomized clinical trial was conducted in October 2012 to February 2013 on hypertensive elderly patients at Cipto Mangunkusumo hospital, Jakarta. Subjects were divided into 3 groups: group I was received structured education and checklist, group II was received structured education, and group III was received checklist without structured education. Structured education was given 3 times per month for 90 days. Systolic and diastolic blood pressure (SBP and DBP) were measured on day-1 and day-90, then analyzed with anova test. Results. A total of 182 subjects that consisted of 60 subjects in group I, 61 subjects in group II and 61 subjects in group III was included in this study. Analysis results showed a decrease of SBP in group I, II and III to 130 (range 90-179) mmHg, 135 (range 80-174) mmHg and 133 (range 102-209) mmHg, respectively (p=0.04). Diastolic blood pressure (DBP) in group I, II, and III decreased to 70 (range 48-100) mmHg, 74 (range 45-103) mmHg and 78 (range 60-102) mmHg, respectively (p <0.001). Conclusions. Structured education significantly decreased systolic and diastolic blood pressure in elderly hypertensive patients, while adherence to antihypertensive medication did not affect signicifantly.
Change of Interleukin-6, C-Reactive Protein and Soluble VascularCell Adhesion Molecule-1 Concentrations in HemodialysisPatients with Reprocessed Dialyzer Nugroho, Pringgodigdo; Lydia, Aida; Panggabean, Marulam MP
Jurnal Penyakit Dalam Indonesia Vol. 3, No. 3
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Introduction. Cardiovascular disease is a major cause of morbidity and mortality in hemodialysis patients. In addition to traditional cardiovascular risk factors, non-traditional cardiovascular risk factors such as inflammation were also involved. Reprocessed dialyzer has been showed to induce less inflammation than new dialyzer, but data in diacetate cellulose membrane have not been presented. Methods. Twenty hemodialysis (HD) patients were enrolled. Pre and post study design was conducted to know post dialysis concentration changes of interleukin 6 (IL-6), C-reactive protein (CRP) and soluble vascular cell adhesion molecule-1 (sVCAM-1) at reuse 0, 5 and 10. Patients were recruited if medically stable, on maintenance HD >3 months, using reprocessed diacetate cellulose membrane by automated machine with mixture of periacetic acid and hydrogen peroxide solution. Urea reduction ratio (URR) and delivered dialysis dose were used to evaluate dialysis adequacy at reuse 0, 5, and 10. Results. CRP concentration was decreased. Median concentration of CRP at reuse 0, 5 and 10 were 3.55 mg/L, 2.97 mg/L and 2.92 mg/L, p=0.074. There were no significant changes of IL-6 concentration. Median concentration of IL-6 at reuse 0, 5, and 10 were 9.05 pg/ml, 10.64 pg/ml and 8.51 pg/ml, p=0.316. Concentration of sVCAM-1 was not changed significantly, with mean sVCAM-1 concentration 3078±786 ng/ml, 3260±836 ng/ml and 3154±631 ng/ml at reuse 0, 5 and 10,p=0.746. During use of reprocessed dialyzer through 10 times, there were no significant changes of hemodialysis adequacy using URR and Kt/V.
Pengembangan Model Prediksi Mortalitas 3 Bulan Pertama pada Pasien Penyakit Ginjal Kronik yang Menjalani Hemodialisis Umami, Vidhia; Lydia, Aida; Nainggolan, Ginova; Setiati, Siti
Jurnal Penyakit Dalam Indonesia Vol. 2, No. 3
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Pendahuluan: Mortalitas pasien yang menjalani hemodialisis (HD) paling tinggi pada tiga bulan pertama. Data mengenai insidens dan prediktor mortalitas dini pada pasien HD sangat terbatas. Suatu model prediksi dapat menjadi alat bantu yang sederhana untuk mengetahui pasien yang berisiko tinggi sehingga pada akhirnya upaya pencegahan dapat dilakukan. Penelitian ini bertujuan untuk mengetahui insidens dan prediktor mortalitas 3 bulan pada pasien hemodialisis baru dan membuat suatu model prediksi. Metode: Penelitian dengan disain kohort retrospektif terhadap 246 pasien PGTA yang baru menjalani HD di Unit HD RSCM antara Januari 2011-Januari 2012. Dilakukan analisis chi-square untuk mendapatkan nilai OR (Odds Ratio) terhadap variabel usia, pembiayaan, jenis HD, akses pembuluh darah, anemia, hipoalbuminemia, kelainan EKG, kardiomegali, komorbid, waktu rujukan ke nefrologis, dan kepatuhan. Prediktor yang bermakna kemudian dimasukkan pada model regresi logistik untuk mendapatkan sistem skor. Hasil: Sebanyak 78 (31,7%) dari 246 pasien meninggal dalam 3 bulan pertama. Terdapat 5 variabel yang berhubungan dengan terjadinya mortalitas 3 bulan yaitu usia > 60 tahun, hemoglobin/dl, albumin serum Simpulan: Insidens mortalitas 3 bulan pada pasien HD baru sebesar 31,7%. Usia > 60 tahun, hemoglobin/dl, albumin serum
Serokonversi Hepatitis C pada Pasien Hemodialisis di Rumah Sakit Cipto Mangunkusumo Widhani, Alvina; Lydia, Aida; Gani, Rino A; Setiati, Siti
Jurnal Penyakit Dalam Indonesia Vol. 2, No. 1
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Pendahuluan. Pasien hemodialisis (HD) tergolong kelompok risiko tinggi terinfeksi virus hepatitis C. Penelitian mengenai serokonversi hepatitis C di RS Cipto Mangunkusumo belum pernah dilakukan. Agar transmisi hepatitis C dapat diturunkan, faktor risiko serokonversi hepatitis C penting diketahui. Penelitian ini bertujuan mengetahui proporsi dan faktor risiko serokonversi hepatitis C pada pasien yang menjalani HD di RS Cipto Mangunkusumo. Metode. Penelitian potong lintang terhadap pasien yang menjalani HD di RS Cipto Mangunkusumo pada bulan Juni-Juli 2011. Pemeriksaan anti-HCV menggunakan Roche Elecsys ECLIA, Analisis multivariat menggunakan regresi logistik. Hasil. Pada bulan Juni-Juli 2011 terdapat 135 pasien HD yang memenuhi kriteria inklusi dan eksklusi. Serokonversi mencapai 21,5%. Analisis bivariat menunjukkan hubungan yang bermakna antara lama dialisis (p=0,003) dan jenis kelamin pria (OR 2,43; 95%CI 0,99-5,98; p=0,048) dengan serokonversi hepatitis C. Pasien yang menjalani dialisis >42 bulan (sebelum pemrosesan ulang dialiser menggunakan mesin) lebih banyak yang mengalami serokonversi dibandingkan pasien yang menjalani dialisis ≤42 bulan. Terdapat dua variabel yang marginally statistically significant yaitu HBsAg negatif (p=0,07) dan menggunakan dialiser proses ulang (p=0,07). Pada analisis multivariat, didapatkan jenis kelamin pria (OR 2,91; 95%CI 1,14-7,48; p=0,03) dan lama dialisis (OR 1,02; 95%CI 1-1,03; p=0,007) berhubungan dengan serokonversi hepatitis C. Simpulan. Serokonversi hepatitis C pada pasien yang menjalani HD di RS Cipto Mangunkusumo mencapai 21,5%. Terdapat hubungan signifikan antara jenis kelamin pria dan lama dialisis dengan serokonversi hepatititis C.
The Association between Vitamin D 25(OH)D Level andAlbuminuria in Type 2 Diabetes Mellitus Indra, Tities Anggraeni; Lydia, Aida; Purnamasari, Dyah; Setiati, Siti
Jurnal Penyakit Dalam Indonesia Vol. 4, No. 1
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Introduction. Vitamin D 25(OH)D deficiency was reported as a possible risk factor for the development of diabetic nephropathy in several epidemiologic studies. Whether vitamin D 25(OH)D deficiency plays a role in the development of diabetic nephropathy in Indonesia is unknown. This study aims to determinate the association between vitamin D 25(OH)D level with albuminuria in patients with type 2 diabetes mellitus in Indonesia. Methods. A cross-sectional study was conducted in 96 patients with type 2 diabetes mellitus at outpatient clinic of MetabolicEndocrine Cipto Mangunkusumo Hospital. Serum vitamin D level was assessed using Diasorin kit with CLIA method, while albuminuria was assessed using random urine sample. Statistical analysis was conducted using chi square for bivariate analysis and regression logistic method for multivariate analysis. Results.The prevalence of vitamin D 25(OH)D deficiency in patients with type 2 diabetes mellitus was 49% with a median value 16,35 (4,2-41,4) ng/mL. There was no significant correlation between vitamin D deficiency with the severity of albuminuria (OR 0,887; 95% CI 0,335 to 2,296). Confounding factors such as poor blood glucose control and overweight strongly influenced the association between vitamin D deficiency with the incidence of albuminuria in patients with type 2 diabetes mellitus. Conclusion. The results of this study showed that there was no association between vitamin D deficiency with the severity of albuminuria in patients with type 2 diabetes mellitus in Indonesia.
Correlation of Fibroblast Growth Factor-23 Levels with Hand Grip Strength in Twice Weekly Hemodialysis Patients Lydia, Aida; Gaol, Donnie Lumban; Suhardjono, Suhardjono; Abdullah, Murdani
Jurnal Penyakit Dalam Indonesia Vol. 7, No. 1
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Co-Authors Ailinda Theodora Tedja, Ailinda Theodora Alvina Widhani, Alvina Aulia Rizka, Aulia Ayatullah Khomaini Dharmeizar Dharmeizar Dyah Purnamasari Endang Susalit Esthika Dewiasty, Esthika Fify Henrika, Fify Gaol, Donnie Lumban Ginova Nainggolan Hamzah Shatri Meilania Saraswati Muhammad Yamin Murdani Abdullah Panggabean, Marulam MP Pattiiha, Arief Pringgodigdo Nugroho, Pringgodigdo Rachmaningrum, Grecia Riadi Wirawan Rino A Gani Saraswati, Mita Hafsah Siti Setiati Suhardjono Suhardjono Tities Anggraeni Indra, Tities Anggraeni Vidhia Umami, Vidhia