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All Journal Jurnal Penyakit Dalam Indonesia
Findy Prasetyawaty, Findy
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Medicine & Pharmacology

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Prevalence of Geriatric Syndromes in Elderly Undergoing Chemotherapy Rizka, Aulia; Helda, Helda; Prasetyawaty, Findy; Hanjani, Arcita
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 3
Publisher : UI Scholars Hub

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Introduction. Geriatric syndromes is associated with poor survival, poor quality of life and increased chemotoxicity risk in elderly receiving chemotherapy. Geriatric syndromes is currently not routinely evaluated in pre-chemotherapy clinical setting. This study aimed to identify the prevalence of some geriatric syndromes in elderly patients undergoing chemotherapy.Methods. This study is part of primary study investigating geriatric syndromes in elderly with cancer. A descriptive cross sectional study during March 2020 – March 2021 was conducted to elderly patients before chemotherapy administration in Cipto Mangunkusumo Hospital, a national referral hospital in Jakarta. Patients were recruited consecutively. Patients underwent Comprehensive Geriatric Assesment (CGA), including nutritional, depression, sarcopenia risk assessment, frailty, cognitive assessment, as well as medication review.Results. Total of140 elderly subjects were recruited with mean age of 66 years old. 52% subjects were women and 67% with solid tumor. As many as 80% subjects were having malnutrition, 40,6% were frailt, 40,3% were at high risk of sarcopenia, 14,1% with depression, and 19,1% were having cognitive impairment. Of all subjects, 24,1% have more than 3 diagnosis of geriatric syndromes.Conclusion. As geriatric syndromes are prevalent among elderly subjects receiving chemotherapy, routine identification would be useful to improve cancer treatment result.
Predictors of Health-Related Quality of Life in Adult HemophiliaPatients in Cipto Mangunkusumo Hospital Prasetyawaty, Findy; Sukrisman, Lugyanti; Setyohadi, Bambang
Jurnal Penyakit Dalam Indonesia Vol. 3, No. 3
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Introduction. Currently, one of the main focus of hemophilia treatment is to increase health-related quality of life. Due to financial constraints, factor VIII substitution is used only on demand in Indonesia, which might contribute to musculoskeletal complications and affect the quality of life of adult hemophilia patients. This study aimed to evaluate quality of life of adult hemophilic patients and its related factors. Methods. A cross-sectional study on hemophilia patients aged 18 years or older was conducted at the Hematology-Medical Oncology outpatient clinic, Cipto Mangunkusumo Hospital Jakarta from March to May 2012. The radiologic assessment for arthropathy used the Arnold-Hilgartner score and health-related quality of life was assessed by the SF-36 questionnaire, using norm-based scoring system with normal value of 45 (individual) and 47 (group scale score). Subjects were categorized based on the level of factor VIII or IX and clinical severity (the number of bleeding episodes during the last 12 months). Results. In 66 subjects aged 18-57 (median 28) years old, the scores of the SF-36 ranged from 42.1 (role physical) to 60.9 (vitality). The physical and mental component summary scored 40.0 and 57.7. Clinical severity (p=0.001) and the severity of arthropathy (p=0.034) significantly influenced the SF-36 scores. The multivariate analysis showed that clinical severity significantly influenced the SF-36 scores (p=0.004; AUC 73%). The combination of clinical severity and severity of arthropaty increased the AUC to 76.6%. Conclusions. Health-related quality of life in adult hemophilia showed poor results in physical components. The clinical severity and arthropathy were predictors of health-related quality of life in adult hemophilic patients. The combination of clinical severity and arthropathy had better value in predicting health-related quality of life in adult hemophilia.
Co-Authors Arcita Hanjani, Arcita Aulia Rizka, Aulia Bambang Setyohadi Helda Helda Lugyanti Sukrisman Marcel Prasetyo Siti Setiati