Article Per Year (5 Year)
p-Index From 2019 - 2024
0.23
P-Index
This Author published in this journals
All Journal Molekul: Jurnal Ilmiah Kimia
Mudasir Mudasir
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada
Biochemistry, Genetics & Molecular Biology Chemistry Materials Science & Nanotechnology

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Chiral Separation of Econazole by High Performance Liquid Chromatography Method using Cyclodextrin as Chiral Column Dadan Hermawan; Cacu Cacu; Khansa Salsabila; Suwandri Suwandri; Amin Fatoni; Uyi Sulaeman; Ponco Iswanto; Mudasir Mudasir; Hassan Y. Aboul-Enein
Molekul Vol 17 No 2 (2022)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2022.17.2.6348

Abstract

The chiral separation of econazole, an antifungal drug with one chiral center has been successfully carried out using the high-performance liquid chromatography (HPLC) method. Enantioresolution of econazole (Rs = 2.29) was achieved using cyclodextrin-based chiral column (Astec Cyclobond, 25 cm × 4.6 mm × 5 μm), mobile phase composition of acetonitrile : water (0.2% HCOOH) (20:80, v/v), and UV detection of 220 nm.The optimized HPLC method has been applied for the quantitative determination of econazole in the pharmaceutical (liquid) sample withpercentage recovery of 100.75 % (RSD = 0,95%; n = 3). The effect of several HPLC parameters on the chiral separation of econazole was also evaluated and the method was successfully validated in terms of linearity, accuracy, precision, and selectivity. The present HPLC method was simple, short analysis time, and high resolution.
Co-Authors AMIN FATONI Cacu Cacu Dadan Hermawan Hassan Y. Aboul-Enein Khansa Salsabila Ponco Iswanto Suwandri Suwandri Uyi Sulaeman