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Ali Ramzi
Universitas Mataram
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Physics Social Sciences

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Journal : Jurnal Biologi Tropis

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Chikungunya: Diagnostic, Treatment and Challenge in Indonesia Ali Ramzi
Jurnal Biologi Tropis Vol. 23 No. 1 (2023): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v23i1.5743

Abstract

Chikungunya based on the literature is classified as one of the many diseases that become a differential diagnosis of acute undifferentiated fever. Finally, patients with this condition are treated with empirical therapy so that often the management does not meet the standards / undertreatment. In an effort to reduce morbidity and improve the quality of care with limited modalities, history taking and physical examination as well as effective risk factor analysis are necessary in the current situation in Indonesia. Therefore, the authors raise this topic to help improve diagnostic acuity and the importance of the role of laboratory modalities in the diagnosis of chikungunya in Indonesia. Google Scholar by using the search keywords "Chikungunya" and "In Indonesia" with a time span of 2013-2023. Through a search that has been carried out using these 2 keywords, we get 10,300 publications. Based on the inclusion and exclusion results, 30 publications were obtained that could be used in compiling our literature review. Indonesia is an archipelago and is one of the countries in the world with a tropical climate, so it is certainly an ideal place for various tropical infectious diseases such as chikungunya. Although Indonesia has suppressed chikungunya incidence, Indonesia still facing some problem on diagnostic and case reporting system. This situation effect the performance of incidence validity and quality of treatment.  Chikungunya virus infection in Indonesia still requires diagnostic development efforts to anticipate future outbreaks.
Giant Cell Tumor: Pathogenesis and Clinical Manifestation Adinda Ilsa Maulida; Ali Ramzi; Amrullah Muliawan H; Baiq Ghassani Kayla; Clara Nadila; Dinda Salsabila; Febbi Anggy; Herodya Lajunee Fesmia; Jihan Alifa Rahma; Trisna Ayu Kurnia Putri; Wina Aryslia Fakar; Zulfa Hasyimiyyah Ihtisyam; Nurhidayati Nurhidayati
Jurnal Biologi Tropis Vol. 23 No. 1 (2023): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v23i4b.5831

Abstract

A giant cell tumor of bone (GCTB) as known as a benign bone tumor (neoplasm) is aggressive locally and frequently recurs, and it is characterized by the growth of mononuclear stromal cells and datia cells that resemble osteoclasts. GCTB has varying incidence rates and has been shown to have high mortality. GCTB patients have several treatment options, but the majority of patients still experience recurrence and even metastasis to other organs. This literature review aims to explain more deeply about Giant Cell Tumor (GCT) starting from the definition, etiology, epidemiology, pathogenesis, clinical manifestations and treatment options so that patients get a better prognosis. This literature review was conducted using the keywords "Giant Cell Tumor AND pathogenesis AND clinical manifestation" from PubMed dan Google Scholar. The results of the literature review carried out are that the molecular and biological pathogenesis of GCTB consists of 4 processes, namely tumorigenesis of neoplastic mononuclear stromal cells, generation of reactive multinucleated giant cells, bone resorption/migration, and bone matrix remodeling for angiogenesis, invasiveness, and metastasis. Besides, the histological picture of GCTB contains "reactive" osteoclasts such as multinucleated giant cells (Giant Cells/GC), round cells such as macrophages and spindle stromal cells such as "neoplastic" fibroblasts (mononuclear stromal cells/SC) which are important findings in establishing the diagnosis. In conclusion, staging and management are very important to produce a better prognosis and reduce recurrence rates in GCTB patients.
Factors That Determine the Successful Management of Ectopic Pregnancy Through Methotrexate Injections Baiq Ayu Rahmawati; Amelia Wahyu Maharani; Ali Ramzi; Muhammad Rizkinov Jumsa
Jurnal Biologi Tropis Vol. 23 No. 1 (2023): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v23i4b.5907

Abstract

Ectopic pregnancy is a pregnancy that occurs when the gestational sac is located outside the uterus. Methotrexate administered intramuscularly (IM) is the standard management in the therapy of ectopic pregnancies. The success of managing ectopic pregnancies using methotrexate is influenced by various factors. This literature review aims to provide related information because a sufficient understanding of the factors that affect the success of methotrexate use in ectopic pregnancies is crucial to prevent complications, reduce morbidity and mortality rates resulting from ectopic pregnancies. In this literature review we conducted a search on the National Center for Biotechnology Information (NCBI) and Google Scholar database using the search keyword factors, methotrexate, and ectopic pregnancy. The success of treating ectopic pregnancies using methotrexate is influenced by various factors, such as the initial β-hCG levels, the size of the ectopic mass, peritoneal fluid, maternal age, gestational age, previous spontaneous miscarriage, gravida, parity, abortion, and the percentage of a history of previous ectopic pregnancies. However, most studies have found that the primary factor influencing success is the initial β-hCG levels.
Co-Authors Adinda Ilsa Maulida Alma Dyah Perwita Amelia Wahyu Maharani Amrullah Muliawan H Baiq Ayu Rahmawati Baiq Ghassani Kayla Clara Nadila Dinda Salsabila Febbi Anggy Herodya Lajunee Fesmia Jihan Alifa Rahma Muhammad Rizkinov Jumsa Nurhidayati Nurhidayati Trisna Ayu Kurnia Putri Ulul Azmi Wina Aryslia Fakar Zulfa Hasyimiyyah Ihtisyam