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All Journal Jurnal Biologi Tropis JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Febbi Anggy
Universitas Mataram
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Faktor – Faktor Terkait Tingkat Keparahan Infeksi Coronavirus Disease 2019 (COVID-19): Sebuah Kajian Literatur Abiyyu Didar Haq; Adli Putra Nugraha; I Komang Gede Andhika Wibisana; Febbi Anggy; Fiana Damayanti; R.R. Ditya Mutiara Syifa; Ni Putu Visty Widhiani; Cut Warnaini
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 1 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.1 Edisi Maret - Juli
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i1.338

Abstract

Background: COVID-19 pandemic that started in the early 2020 triggers the declaration of Public Health Emergency of International Concern (PHEIC) by WHO. Caused by SARS-CoV-2 virus, COVID-19 mainly infects the respiratory tract by binding to the ACE2 receptor. COVID-19 infection can cause many clinical manifestation from no symptom to severe life-threatening symptom depending on many factors. Factors that can determine the severity of clinical manifestation is urgently needed to be recognized by our clinician in order to be able to anticipate patient’s condition before the severe clinical manifestation even begins. This literature review is aimed to summarize and discuss some factors that are most often showed up and determined the severity of COVID-19 infection. Methods: This literature review uses journal article that are sourced from online databases such as PubMed and Google Scholar. The type of article that will be chosen are research article, systematic review and meta-analysis, narrative review, and literature review with the topic of transmission, clinical manifestasion, pathogenesis, immune response, and severity risk factor of COVID-19. Discussion: From our literature search, it is concluded that the factors that are most likely to determine the severity of COVID-19 infection is age, comorbid disease, vitamin D deficiency, and obesity. These four factors are not four independent factors but rather overlapping and interconnecting factors that determines the severity of COVID-19 infection. Conclusion: Most of the factors that determined the severity of COVID-19 mainly are easily preventable factors. Therefore, the knowledge and awareness of our clinician about these factors will really helps anticipating the severe clinical manifestation among COVID-19 patients before the manifestation even starts to appear.
Cholangiocarcinoma: Risk Factors, Diagnostic Tools, and Current Treatment Options Adli Putra Nugraha; Baiq Ghassani Kayla; Febbi Anggy; Ni Made Utami Wulandari; Wina Arsylia Fakar; Philip Habib
Jurnal Biologi Tropis Vol. 23 No. 4 (2023): October - December
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v23i4.5741

Abstract

Cholangiocarcinoma is a disease caused by the differentiation of cells in the bile epithelium or liver parenchyma into malignant cells called cholangiocytes. This literature review presents the current risk factors, diagnostic tools, and treatment choices of cholangiocarcinoma. Publication about the current risk factors, diagnostic tools, and treatment choices of cholangiocarcinoma were collected from the Pubmed database until August 25, 2022. The keywords of the research were “cholangiocarcinoma”, “risk factor”, “diagnostic”, and “treatment”. Cholangiocarcinoma has many risk factors, from choledochal cysts, and primary sclerosing cholangitis, to asbestos exposure. The diagnosis of cholangiocarcinoma is difficult and requires the combined interpretation of different diagnostic modalities. Examinations that can be done for the diagnosis and staging of cholangiocarcinoma are MRI and CT. However, if the diagnosis remains uncertain, endoscopic examination and tissue sampling may be performed. After the diagnosis, there are several treatments, namely surgical therapy (surgical excision of bile duct tumors), endoscopic therapy (endoscopic biliary dilatation), radiological therapy (percutaneous transhepatic palliative biliary dilatation), chemotherapy and radiotherapy, and photodynamic therapy. Cholangiocarcinoma is a malignancy of cells in the biliary epithelium or liver parenchyma (cholangiocytes) that has many risk factors. The diagnosis of cholangiocarcinoma is difficult and requires a combined interpretation of the different diagnostic modalities, including MRI, CT, endoscopy, and tissue sampling. After the diagnosis, there are several treatments, namely surgical therapy, endoscopy, radiology therapy, chemotherapy and radiotherapy, and photodynamic therapy.
Giant Cell Tumor: Pathogenesis and Clinical Manifestation Adinda Ilsa Maulida; Ali Ramzi; Amrullah Muliawan H; Baiq Ghassani Kayla; Clara Nadila; Dinda Salsabila; Febbi Anggy; Herodya Lajunee Fesmia; Jihan Alifa Rahma; Trisna Ayu Kurnia Putri; Wina Aryslia Fakar; Zulfa Hasyimiyyah Ihtisyam; Nurhidayati Nurhidayati
Jurnal Biologi Tropis Vol. 23 No. 1 (2023): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v23i4b.5831

Abstract

A giant cell tumor of bone (GCTB) as known as a benign bone tumor (neoplasm) is aggressive locally and frequently recurs, and it is characterized by the growth of mononuclear stromal cells and datia cells that resemble osteoclasts. GCTB has varying incidence rates and has been shown to have high mortality. GCTB patients have several treatment options, but the majority of patients still experience recurrence and even metastasis to other organs. This literature review aims to explain more deeply about Giant Cell Tumor (GCT) starting from the definition, etiology, epidemiology, pathogenesis, clinical manifestations and treatment options so that patients get a better prognosis. This literature review was conducted using the keywords "Giant Cell Tumor AND pathogenesis AND clinical manifestation" from PubMed dan Google Scholar. The results of the literature review carried out are that the molecular and biological pathogenesis of GCTB consists of 4 processes, namely tumorigenesis of neoplastic mononuclear stromal cells, generation of reactive multinucleated giant cells, bone resorption/migration, and bone matrix remodeling for angiogenesis, invasiveness, and metastasis. Besides, the histological picture of GCTB contains "reactive" osteoclasts such as multinucleated giant cells (Giant Cells/GC), round cells such as macrophages and spindle stromal cells such as "neoplastic" fibroblasts (mononuclear stromal cells/SC) which are important findings in establishing the diagnosis. In conclusion, staging and management are very important to produce a better prognosis and reduce recurrence rates in GCTB patients.
Co-Authors Abiyyu Didar Haq Adinda Ilsa Maulida Adli Putra Nugraha Ali Ramzi Amrullah Muliawan H Baiq Ghassani Kayla Clara Nadila Cut Warnaini Dinda Salsabila Fiana Damayanti Herodya Lajunee Fesmia I Komang Gede Andhika Wibisana Jihan Alifa Rahma Ni Made Utami Wulandari Ni Putu Visty Widhiani Nurhidayati Nurhidayati Philip Habib R.R. Ditya Mutiara Syifa Trisna Ayu Kurnia Putri Wina Arsylia Fakar Wina Aryslia Fakar Zulfa Hasyimiyyah Ihtisyam