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All Journal Jurnal Biologi Tropis Journal of Social Science
Alma Dyah Perwita
Universitas Mataram
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Physics Social Sciences

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Understanding and Addressing the Challenges of Gastrointestinal Stromal Tumor (GIST): Towards Improved Diagnosis and Treatment Strategies Ali Ramzi; Alma Dyah Perwita; Dinda Salsabila; Trisna Ayu Kurnia Putri; Ulul Azmi
Journal of Social Science Vol. 4 No. 5 (2023): Journal of Social Science
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jss.v4i5.705

Abstract

Gastrointestinal stromal tumor (GIST) is a prevalent mesenchymal tumor affecting the digestive tract, with the stomach being the most common location. While some GIST cases are sporadic with no known risk factors, certain factors like age and genetic abnormalities increase the risk. Early diagnosis of GIST remains challenging due to atypical symptoms, leading to late diagnoses and reduced survival rates. This research aims to identify specific risk factors related to local populations, develop accurate early diagnosis methods, and formulate more effective treatment strategies. The study involves a retrospective observational approach, collecting data from medical records of GIST patients and analyzing risk factors and treatment outcomes. The results highlight the increasing prevalence of GIST globally, emphasizing the need for increased awareness and early diagnosis. Challenges in early diagnosis and treatment underscore the importance of public awareness, medical education, and collaborative efforts for better GIST management. This research offers implications for the development of diagnostic guidelines and more effective treatment approaches, ultimately improving the prognosis and quality of life for GIST patients.
Precocious Puberty: Etiology and Current Treatment Jihan Alifa Rahma; Adinda Ilsa Maulida; Alma Dyah Perwita; Baiq Ayu Rahmawati; Clara Nadila; Herodya Lajunee Fesmia; Ni Made Utami Wulandari; Zhayyin Palna Rial Novsyaini; Indana Eva Ajmala
Jurnal Biologi Tropis Vol. 23 No. 1 (2023): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v23i1.5926

Abstract

Precocious puberty also known as premature puberty is an abnormal pubertal development that can affect a child's growth and development. The clinical manifestations of precocious puberty are generally diverse and based on etiology are classified into central precocious puberty (GnRH dependent) and peripheral precocious puberty (GnRH independent). The main concern with precocious puberty is that precocious puberty can be a clinical symptom of an underlying serious disease such as a brain tumor, adrenal or gonadal tumor and others. Early identification of etiology plays an important role in prevention, diagnosis, and treatment of this disease. This literature review aims to determine the etiology and current management of precocious puberty. This literature review uses the keywords "Precocious Puberty AND etiology AND treatment" through the National Center for Biotechnology Information (NCBI) and Google Scholar databases. This article uses 11 articles that were used as references in its preparation. In conclusion, it is necessary to know the etiology of precocious puberty using imaging examinations for optimal management and excluding malignant abnormalities. The current treatment for central precocious puberty is GnRH agonists (gold-standard) and surgery in cases of intracranial lesions and peripheral precocious puberty using a combination of androgen antagonists (spironolactone) and aromatase inhibitors (anastrozole, testolactone) and surgery is indicated for gonadal and adrenal tumors. The role of parents is very important in early detection of precocious puberty, because the earlier the therapy, the better the prognosis.
Co-Authors Adinda Ilsa Maulida Ali Ramzi Baiq Ayu Rahmawati Clara Nadila Dinda Salsabila Herodya Lajunee Fesmia Indana Eva Ajmala Jihan Alifa Rahma Ni Made Utami Wulandari Trisna Ayu Kurnia Putri Ulul Azmi Zhayyin Palna Rial Novsyaini