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Pearla Lasut
Universitas Sam Ratulangi
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Nursing Public Health

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Correlation of Plasma Iron Profile and Intradialytic Hypotension in Hemodialysis Patients Tisa Rombot; Stella Palar; Pearla Lasut
Medical Scope Journal Vol. 5 No. 2 (2023): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v5i2.49567

Abstract

Abstract: Intradialytic hypotension (IDH) has been a common complication which should be aware of, in hemodialysis procedure. Its pathogenesis is multifactorial, and severe anemia is considered as one of the most notable risk factors on IDH. This study aimed to evaluate the correlation between plasma iron profile and intradialytic hypotension in hemodialysis patients. This was an analytical and retrospective study using medical records of hemodialysis patients at Prof. Dr. R. D. Kandou Hospital, Manado from January to May 2022. Sampling was conducted through consecutive sampling method, on available records.  Patients with CKD grade 5 which undergoes routine HD twice a week for >3 weeks, aged 18-60 years old were included, while subjects with sepsis, malignancy, autoimmune disease, crisis hypertension, and unstable congestive heart failure were excluded for further studies. The details on iron profile and blood pressure measurement were then extracted, which then analyzed with descriptive analysis and Pearson correlation using IBM SPSS Statistics 26.0. The results obtained a total of 35 patients; 57.1% were male. The Pearson correlation analysis on all variables reported several notable significant results, with a correlation between iron profile and blood pressure measurement were seen in TIBC and systole pre- and post-procedure (-.496 and -.611 respectively) with strong negative relationship; and serum ferritin value with systole post-procedure (.373) implying moderate positive relationship. The results suggested that the increase of ferritin value and decrease of TIBC value were correlated with the increase of systole blood pressure. Meanwhile, the TIBC had a strong positive correlation with systolic changes (.473) meanwhile serum iron had a moderate negative correlation with diastolic changes (-.365). In conclusion, there is a significant correlation between iron profile and changes in blood pressure, with higher iron profile value (lower TIBC) is positively correlated with the increase of both systole and diastole measurement; also negatively correlated with the reduction of blood pressure in hemodialysis patients Keywords: iron; ferritin; intradialytic hypotension; hemodialysis; transferrin; total iron binding capacity
Hubungan Neutrophil Lymphocyte Ratio, Platelet Lymphocyte Ratio, dan Ferritin dengan Pemberian Remdesivir pada Pasien Covid-19 dengan Peningkatan Transaminase Linda W. A. Rotty; Decky Andrea; Fujiyanto Fujiyanto; Harlinda Haroen; Pearla Lasut; Cecilia Hendratta; Agung Nugroho; Efata Polii
e-CliniC Vol. 11 No. 3 (2023): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v11i3.46845

Abstract

Abstract: Remdesivir is used as the treatment for coronavirus disease 2019 (Covid-19). Moreover, its pharmacological effect has an impact on the improvement of inflammatory biomarkers. Neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and ferritin are simple inflammation parameters that are widely available and can describe inflammation in Covid-19 patients. This cross-sectional study involved 52 Covid-19 patients at Prof. Dr. R. D. Kandou Hospital from March 2020 to March 2021. Blood tests were performed on the day before remdesivir administration and one week after administration. The results obtained a significant correlation between NLR and PLR with a value of r=0.641-0.670 (p<0.001) before and after administration of remdesivir. In all patients there was a decrease in ferritin with remdesivir administration (∆= -111.41). In conclusion, there are decreases in NLR, PLR and ferritin values ​​in Covid-19 patients with increased transaminase after being treated with remdesivir, especially living patients. Keywords: remdesivir; coronavirus disease 2019 (Covid-19); platelet lymphocyte ratio; neutrophil lymphocyte ratio; ferritin   Abstrak: Remdesivir termasuk dalam tatalaksana coronavirus disease 2019 (Covid-19). Efek farmakologik remdesivir juga berdampak terhadap perbaikan biomarker inflamasi. Neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), dan feritin merupakan parameter inflamasi sederhana yang banyak tersedia dan dapat menggambarkan inflamasi pada pasien Covid-19. Studi potong lintang ini menelaah 52 pasien Covid-19 di RSUP Prof. Dr. R. D. Kandou sejak Maret 2020 hingga Maret 2021. Pemeriksaan darah diambil pada hari sebelum pemberian remdesivir dan satu minggu setelah pemberian. Hasil penelitian mendapatkan korelasi bermakna antara NLR dan PLR dengan nilai r=0,641-0,670 (p<0,001) baik sebelum dan setelah pemberian remdesivir. Pada keseluruhan pasien terdapat penurunan ferritin dengan pemberian remdesivir (∆=-111,41). Simpulan penelitian ini ialah terdapat penurunan nilai NLR, PLR dan ferritin pada pasien Covid-19 setelah diberikan remdesivir terutama pasien hidup. Kata kunci: remdesivir; coronavirus disease 2019 (Covid-19); platelet lymphocyte ratio; neutrophil lymphocyte ratio; feritin
Tingkat Depresi, Cemas, dan Stres pada Pasien Kanker yang Menjalani Kemoterapi Johanes A. Mastan; Linda W. A. Rotty; Harlinda Haroen; Cecilia Hendratta; Pearla Lasut
Medical Scope Journal Vol. 6 No. 2 (2024): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v6i2.53335

Abstract

Abstract: Chemotherapy in cancer patients has psychological impacts which are depression, anxiety and stress. This study aimed to evaluate the levels of depression, anxiety and stress in cancer patients undergoing chemotherapy. This was a descriptive study with a cross-sectional design. Samples were obtained by using non-probability sampling with purposive sampling technique. Subjects were cancer patients undergoing chemotherapy at Prof. Dr. R. D. Kandou Hospital aged over 18 years old, not pregnant, and not having an infectious disease. Assessment of levels of depression, anxiety and stress using DASS-42. The results obtained 62 patients undergoing chemotherapy; 47 were women (75.8%). The median and interquartile age range was 52 (14.75) years and body mass index (BMI) was 22 (5.17), 42 patients having an income <3.5 million rupiahs (67%), 36 patients with duration of illness >1 year (58%) and the majority of patients (79%) were in marital status. Among subjects, 23% experienced depression, 40% experienced generalized anxiety disorder, and 21% experienced stress. In conclusion, patients undergoing chemotherapy can experience depression, anxiety and stress disorders. Keywords: depression; anxiety; stress; chemotherapy; cancer patients   Abstrak: Kemoterapi pada pasien kanker memiliki dampak psikis yaitu depresi, cemas, dan stres. Penelitian ini bertujuan mengetahui tingkat depresi, cemas, dan stres pada pasien kanker yang menjalani kemoterapi. Jenis penelitian ialah deskriptif dengan desain potong lintang. Sampel diperoleh menggunakan non-probability sampling dengan teknik purposive sampling. Subjek penelitian ialah pasien kanker yang menjalani kemoterapi di RSUP Prof. Dr. R. D. Kandou dengan usia di atas 18  tahun, tidak hamil, dan tidak sedang dalam pengobatan penyakit infeksi. Penilaian tingkat depresi, cemas, dan stres menggunakan DASS-42. Hasil penelitian mendapatkan­ 62 pasien yang menjalani kemoterapi; 47 pasien ialah perempuan (75,8%). Median dan interquartil range usia ialah 52 (14,75) tahun dan  IMT 22(5,17), dengan 42 pasien mempunyai pendapatan <3,5 juta rupiah  (67%),  36 pasien dengan lama sakit  >1 tahun (58%) dan sebagian besar pasien (79%) dalam status kawin. Sebanyak 23% pasien mengalami depresi, 40% gangguan cemas menyeluruh, dan 21% mengalami stres. Simpulan penelitian ini ialah pasien yang menjalani kemoterapi dapat mengalami gangguan depresi, cemas dan stres. Kata kunci: depresi; cemas; stres; kemoterapi; pasien kanker
Co-Authors Agung Nugroho Cecilia Hendratta Decky Andrea Efata Polii Fujiyanto Fujiyanto Harlinda Haroen Johanes A. Mastan Linda W. A. Rotty Stella Palar Tisa Rombot