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All Journal MDJ (Makassar Dental Journal)
Putu Yetty Nugraha
Bagian Ilmu Kedokteran Gigi Anak Fakultas Kedokteran Gigi Univesitas Mahasaraswati-Denpasar Denpasar-Bali, Indonesia
Dentistry

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The effect of cinnamon (Cinnamomum burmannii) leaf extract gel on the number of fibroblasts in healing inflammation of the oral mucosa of white wistar : Efek gel ekstrak daun kayu manis (Cinnamomum burmannii) terhadap jumlah fibroblas pada penyembuhan radang mukosa oral tikus putih galur wistar (Rattus norvegicus) Eko Sri Yuni Astuti; Putu Yetty Nugraha; Komang Ayu Gita Iswari
Makassar Dental Journal Vol. 12 No. 2 (2023): Volume 12 Issue 2 Agustus 2023
Publisher : Makassar Dental Journal PDGI Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35856/mdj.v12i2.776

Abstract

Cinnamon leaves contain flavonoids, alkaloids, steroids and tannins that can help stimulate fibroblast cell formation and inhi-bit bacterial growth with antibacterial, antioxidant and anti-inflammatory activities so as to accelerate the healing process in inflammation. This study aims to determine the optimal concentration of cinnamon leaf extract gel (Cinnamomum burman-nii) 35% on the number of fibroblast cells in healing inflammation of the buccal mucosa of wistar strain white rats (Rattus nor-vegicus). Laboratory experimental research in vivo with randomised post-test only control group design using 30 wistar rats which were divided into three groups: positive control (K+) given H2O2 30% + Aloclair gel; negative control (K-) given H2O2 30%, and the third group (P) given H2O2 30% + 35% DKM extract gel. The results showed the mean number of fibroblast cells in groups (K+), (K-), and (P) were 51.1 cells, 29.1 cells, and 43.8 cells, respectively. All groups showed significantly dif-ferent results (????<0.05) with the one-way Anova test. It is concluded that 35% DKM extract gel can increase the number of fi-broblast cells so that it can effectively heal the inflammation of the buccal mucosa of white wistar rats.
Co-Authors Eko Sri Yuni Astuti Komang Ayu Gita Iswari