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All Journal Abdimasku : Jurnal Pengabdian Masyarakat Medical Sains : Jurnal Ilmiah Kefarmasian Medical Sains : Jurnal Ilmiah Kefarmasian
Septia Devi Amalia
Universitas Muhammadiyah Malang
Computer Science & IT Economics, Econometrics & Finance Health Professions Industrial & Manufacturing Engineering Medicine & Pharmacology Social Sciences

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BIOAVAILABILITY AND MOLECULAR DOCKING PREDICTION OF SECONDARY METABOLITE OF Curcuma zedoaria AS POTENTIAL MPRO SARS COV-2 INHIBITOR Amaliyah Dina Anggraeni; Nia Yuniar Fitriana Putri; Septia Devi Amalia; M. Artabah Muchlisin
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023): Forthcoming Issue
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.805

Abstract

Almost all countries worldwide have been exposed to the COVID-19 pandemic, which can cause respiratory diseases. Therefore, it is necessary to identify and develop drugs for the treatment of COVID-19. White turmeric (Curcuma zedoaria) is very popular because it is effective as an anticancer and antiviral agent. This study used the in silico method to predict the secondary metabolite compounds contained in C. zedoaria as inhibitors of Mpro (main protease) SARS-CoV-2. Of the 30 secondary metabolite compounds identified, 26 compounds had good bioavailability prediction, and three compounds (curcumadiol, curcumin, and desmethoxycurcumin) were predicted to have potential as SARS-COV-2 Mpro inhibitors because they have low inhibition constants and numerous ligand-protein interactions. Curcumadiol have binding energy: -8.34 kcal/mol; pKi: 0.77 µM; hydrogen bond: Glu166, Thr190, and Gln192; and hydrophobic bond: Met165 and Gln189. Curcumin have binding energy: -8.28 kcal/mol; pKi: 0.85 µM; hydrogen bond: Leu141, Gly143, Ser144, and Thr190; and hydrophobic bond: Cys145, Met165, and Gln189. Desmethoxycurcumin have binding energy: -7.83 kcal/mol; pKi: 1.84 µM; hydrogen bond: Asp187, Thr190, and Gln192; and hydrophobic bond: Met165. Keywords: Curcuma zedoaria, SARS-CoV-2, bioavailability, molecular docking
Pemberdayaan Cegah Gout Artritis Pada Lansia Dusun Bakalan Krajan Kota Malang Muhammad Dodik Prastiyo; Rani Rakhmawati; Septia Devi Amalia; Zakiya Amalia Qurana
ABDIMASKU : JURNAL PENGABDIAN MASYARAKAT Vol 6, No 3 (2023): September 2023
Publisher : LPPM UNIVERSITAS DIAN NUSWANTORO

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62411/ja.v6i3.1457

Abstract

Pada usia lansia banyak orang yang tidak menjalani aktivitas fisik, bahkan makan yang tidak terkontrol sehingga akan berdampak pada kondisi gout artritis/asam urat. Lansia dengan kondisi gout artritis akan mengalami keluhan nyeri yang hebat, keterbatasan aktivitas fisik, sehingga berdampak pada penurunan kualitas hidup pada lansia.  Kemenkes pada tahun 2018 melaporkan bahwa gout artritis mencapai 11,9% yang menyebabkan gangguan kemampuan mobilitas, gangguan mengurus diri, dan ketergantungan orang lain. Sehingga upaya promotif seperti pemberdayaan pada lansia perlu dilakukan. Metode pelaksaan pengabdian masyarakat yang digunakan adalah berbasis Service Learning (SL) dengan menggunakan tiga konsep yaitu deteksi atau skrining, penyuluhan, serta pemberdayaan yang dijalankan setiap minggu selama tiga (3) minggu pada lansia di Dusun Bakalan Krajan Kota Malang. Hasil pengabdian masyarakat didapatkan sebanyak (n=18) lansia mengikuti program pemberdayaan, dengan mayoritas berjenis kelamin perempuan (n=10) dengan persentase 55,6%, dan pada rentang usia 60-69 tahun (n=15) dengan persentase 77,8%. Terdapat peningkatan pengetahuan lansia secara signifikan (p=0,014<0,05) dan perubahan pengetahuan dari 14 lansia memiliki pengetahuan buruk, menurun menjadi 5 lansia. Kesimpulan dari pelaksanaan kegiatan pengabdian masyarakat didapatkan antusiasme yang baik mengenai materi penyuluhan dan pemberdayaan yang diberikan, dengan dibuktikan mayoritas lansia memiliki peningkatan pengetahuan.
BIOAVAILABILITY AND MOLECULAR DOCKING PREDICTION OF SECONDARY METABOLITE OF Curcuma zedoaria AS POTENTIAL MPRO SARS COV-2 INHIBITOR Amaliyah Dina Anggraeni; Nia Yuniar Fitriana Putri; Septia Devi Amalia; M. Artabah Muchlisin
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.805

Abstract

Almost all countries worldwide have been exposed to the COVID-19 pandemic, which can cause respiratory diseases. Therefore, it is necessary to identify and develop drugs for the treatment of COVID-19. White turmeric (Curcuma zedoaria) is very popular because it is effective as an anticancer and antiviral agent. This study used the in silico method to predict the secondary metabolite compounds contained in C. zedoaria as inhibitors of Mpro (main protease) SARS-CoV-2. Of the 30 secondary metabolite compounds identified, 26 compounds had good bioavailability prediction, and three compounds (curcumadiol, curcumin, and desmethoxycurcumin) were predicted to have potential as SARS-COV-2 Mpro inhibitors because they have low inhibition constants and numerous ligand-protein interactions. Curcumadiol have binding energy: -8.34 kcal/mol; pKi: 0.77 µM; hydrogen bond: Glu166, Thr190, and Gln192; and hydrophobic bond: Met165 and Gln189. Curcumin have binding energy: -8.28 kcal/mol; pKi: 0.85 µM; hydrogen bond: Leu141, Gly143, Ser144, and Thr190; and hydrophobic bond: Cys145, Met165, and Gln189. Desmethoxycurcumin have binding energy: -7.83 kcal/mol; pKi: 1.84 µM; hydrogen bond: Asp187, Thr190, and Gln192; and hydrophobic bond: Met165. Keywords: Curcuma zedoaria, SARS-CoV-2, bioavailability, molecular docking
Co-Authors Amaliyah Dina Anggraeni M. Artabah Muchlisin Muhammad Dodik Prastiyo Nia Yuniar Fitriana Putri Rani Rakhmawati Zakiya Amalia Qurana