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All Journal Jurnal Farmasi Udayana
Nonye Treasure Ujam
Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmaceutical Sciences, Enugu State University of Science and Technology (ESUT), Enugu State 401105, Nigeria
Medicine & Pharmacology

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Senyawa penuntun antituberkulosis dari jamur yang berasal dari laut dan entomopatogen Ni Luh Putu Indah Suryani; I Putu Yogi Astara Putra; Nonye Treasure Ujam; Ni Putu Ariantari
Jurnal Farmasi Udayana Vol. 12, No 1, Tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i01.p09

Abstract

The occurrence of Mycobacterium tuberculosis resistance encourages the discovery of new antitubercular candidates. Microbes including fungi and bacteria are well known reservoir for isolating antibiotic compounds, among natural product resources. In this review, we report promising antitubercular compounds from marine-derived and entomopathogenic fungi, reported from 2000 to 2022. A comprehensive literature search was conducted through scientific websites, including Google Scholar, Springer, and Pubmed. Eighty-three antitubercular compounds were reported, where 57 of them derived from fungi associated with marine ecosystem. Those fungi belong to 10 fungal genera. The remaining active compounds were isolated from 7 genera of entomopathogenic fungi. Gliotoxin, 12,13-dihydroxy-fumitremorgin, and helvolic acid as well as hirsutellones A-D are among bioactive compounds reported for their remarkable antitubercular activity, which promising to be investigated further in the search of antitubercular leads. Deeper investigation on these compounds might be promising for the the discovery of antitubercular candidates in the future. Keywords: Antitubercular; entomopathogenic fungi; marine-derived fungi; Mycobaterium tuberculosis; secondary metabolites
Co-Authors I Putu Yogi Astara Putra Ni Luh Putu Indah Suryani Ni Putu Ariantari