Garuda - Garba Rujukan Digital

Analisis Interaksi Obat Pada Pasien Rawat Jalan Penderita Penyakit Jantung Koroner di Salah Satu Rumah Sakit di Kota Bandung Muhammad Raja Fachri Buldan; Umi Yuniarni; Fetri Lestari
Bandung Conference Series: Pharmacy Vol. 3 No. 2 (2023): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v3i2.8249

Abstrak. Penyakit jantung koroner (PJK) adalah suatu penyakit gangguan fungsi jantung akibat berkurangnya suplai oksigen ke otot jantung. Hal ini disebabkan oleh adanya penyempitan atau sumbatan pada pembuluh darah koroner. PJK merupakan penyakit kronis dan sering diderita oleh pasien dengan usia lanjut oleh karena itu PJK membutuhkan berbagai macam obat dalam terapinya sehingga memperbesar kemungkinan terjadinya interaksi obat. Tujuan dari penelitian ini adalah untuk mengetahui persentase kemungkinan adanya interaksi obat pada pasien rawat jalan penyakit jantung koroner di salah satu rumah sakit di kota Bandung meliputi jenis obat yang paling sering berpotensi berinteraksi, mekanisme interaksi obat, dan signifikansi interaksi obat. Penelitian yang dilakukan yaitu analitik observasional menggunakan data retrospektif dengan analisis data secara deskriptif dan pengambilan sampel dengan teknik consecutive sampling. Data diambil dari sampel rekam medik pasien rawat jalan penderita PJK di salah satu rumah sakit di kota Bandung periode Januari – Desember 2022. Berdasarkan analisis interaksi obat yang telah dilakukan diketahui 73 resep (97,33%) dari total 75 resep pasien rawat jalan penderita PJK yang kemungkinan berpotensi mengalami interaksi obat dengan total 81 jenis interaksi. Mayoritas interaksi memiliki signifikansi moderate sebanyak 66 kasus (81,48%), lalu minor 8 kasus (9,88%) dan major 7 kasus (8,64%). Jenis obat yang paling sering berinteraksi yaitu aspirin-bisoprolol dengan jumlah 35 kasus (47,94%). Berdasarkan mekanisme interaksi obat mayoritas adalah interaksi dengan mekanisme farmakodinamika dengan jumlah 57 kasus (70,37%). Abstract. Coronary Heart Disease (CHD) is a disease of impaired heart function due to reduced oxygen supply to the heart muscle. This is caused by a narrowing or blockage of the coronary blood vessels. CHD is a chronic disease and is often suffered by patients with advanced age, therefore CHD requires a variety of drugs in its therapy, increasing the possibility of drug interactions. The purpose of this study was to determine the percentage of the possibility of drug interactions in outpatients with coronary heart disease in one of the hospitals in the city of Bandung including the types of drugs that most often have the potential to interact, the mechanism of drug interactions, and the significance of drug interactions. The research conducted was observational analytic using retrospective data with descriptive data analysis and sampling with consecutive sampling technique. Data were taken from a sample of medical records of outpatients with CHD in one of the hospitals in the city of Bandung for the period January - December 2022. Based on the analysis of drug interactions that have been carried out, 73 prescriptions (97.33%) of a total of 75 outpatient prescriptions for patients with CHD are known to have the potential to experience drug interactions with a total of 81 types of interactions. The majority of interactions had moderate significance as many as 66 cases (81.48%), then minor 8 cases (9.88%) and major 7 cases (8.64%). The most common type of drug interaction was aspirin-bisoprolol with 35 cases (47,94%). Based on the mechanism of drug interaction, the majority were pharmacodynamic interactions with 57 cases (70.37%).

Analgesic Effect Test of Ethanol Extract of Kecipir Fruit (Psophocarpus tetragonolobus (L.) DC.) Against Male Mice with the Writhing Method Fitri Nurhalimah; Fetri Lestari; Suwendar
Bandung Conference Series: Pharmacy Vol. 3 No. 2 (2023): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v3i2.8350

Abstract. Pain, as a sensory perception, serves as an indicator of tissue damage, compromised nervous system functionality, or inflammation within the body. The objectives of this research encompassed the evaluation of analgesic activity exhibited by the ethanol extract derived from winged bean and the identification of the optimal dosage of the extract demonstrating analgesic properties in male mice. To achieve these goals, the experimental procedures involved the application of the writhing test. In this procedure, the writhing test was conducted to evaluate the peripheral analgesic activity. For this test, the mice were induced with 1% acetic acid (i.p), and the observed parameters encompassed the quantification of stretching behavior. The study comprised 6 (n=4) experimental groups: Group I served as the negative control and received 1% CMC Na. Group II acted as the positive control and was administered CMC Na along with the pain-inducing agent. Group III served as the comparison group, and the mice were administered paracetamol. Groups IV, V, and VI (Test doses 1,2, and 3) were given winged bean extract at doses of 250 mg/kg BB, 500 mg/kg BB, and 1000 mg/kg BB, respectively. The results unequivocally demonstrated the analgesic activity of the ethanol extract derived from winged bean fruit across all administered doses: 250 mg/kg BB, 500 mg/kg BB, and l000 mg/kg BB. Abstrak. Nyeri diartikan sebagai sensasi yang dirasakan untuk mengindikasikan bahwa sedang terjadinya kerusakan jaringan, tidak berfungsinya sistem saraf atau terjadinya inflamasi pada tubuh. Penelitian bertujuan untuk mengetahui aktivitas analgesik dari ekstrak etanol buah kecipir dan mengetahui dosis terbaik dari ekstrak etanol buah kecipir yang mempunyai aktivitas analgesik pada mencit jantan. Pengujian dilakukan dengan menggunakan metode writhing test, metode writhing test untuk menguji aktivitas analgesik perifer, mencit diinduksi asam asetat 1% (i.p) dengan parameter yang diamati berupa jumlah geliat, pengujian terdiri dari 6 (n=4) kelompok yaitu kelompok I (kontrol negatif) diberi CMC Na 1%, kelompok II (kontrol positif) diberi CMC Na dan induksi, kelompok III (pembanding) diberi parasetamol, kelompok IV, V dan VI (Dosis uji 1,2 dan 3) diberi ekstrak buah kecipir dengan dosis 250 mg/kg BB, 500 mg/kg BB dan 1000 mg/kg BB. Hasil menunjukkan bahwa ekstrak etanol buah kecipir memiliki aktivitas analgesik dengan dosis 250 mg/kg BB, 500 mg/kg BB dan 1000 mg/kg BB.

Study Of Drug Interaction in Diabetes Mellitus Therapy at the Inpatient Installation of Al Islam Hospital Bandung Nabila Nur Azhari; Fetri Lestari; Lanny Mulqie
Bandung Conference Series: Pharmacy Vol. 3 No. 2 (2023): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v3i2.8374

The patient's clinical outcome can be influenced by drug related problems, one of which is drug interactions, because the more complex the therapy carried out, it will be in line with the use of a large number of drugs and the tendency for polypharmacy, so the potential for drug interactions is greater. One of the diseases that can potentially experience drug interactions is type 2 diabetes mellitus, because it has the potential to be prescribed more than two kinds of drugs or even prescribed polypharmacy. This studied aimed to determined the percentage of drug prescriptions that potential to cause drug interactions, determined the mechanism, classification of the impact of drug interactions. The study was conducted analytically observational with retrospective data collection in January-March 2023 using prescription data and medical records of type 2 diabetes mellitus patients hospitalized at Al Islam Hospital Bandung, with purposive sampling technique. From a total of 98 prescriptions, there were 71 prescriptions that had the potential for drug interactions. Consisting of the number of drugs 2- 4 as many as 25 recipes with potential drug interactions 29 (17.37%), while for the number of drugs ≥5 as many as 46 recipes with potential drug interactions 138 (82.63%). Based on the mechanism of drug interactions that occurred, it consisted of pharmacodynamics 142 (85.03%) and pharmacokinetics 25 (14.97%), with the frequency of major severity 5 (3%), moderate 152 (91%) and minor 10 (6%). This study used Stockley’s Drug Interaction E-Book, Drug Interaction Checker and Medscape Drug Interaction Checker to analyze drug interactions. Outcome klinis pasien dapat dipengaruhi oleh drug related problem salah satunya interaksi obat, karena semakin kompleks terapi yang dilakukan maka akan sejalan dengan penggunaan jumlah obat yang banyak dan kecenderungan terjadinya polifarmasi, sehingga potensi interaksi obat semakin besar. Salah satu penyakit yang dapat berpotensi mengalami interaksi obat ialah diabetes melitus tipe 2, karena berpotensi diresepkan lebih dari dua macam obat atau bahkan diresepkan polifarmasi. Penelitian ini bertujuan untuk mengetahui persentase peresepan obat yang berpotensi menimbulkan interaksi obat meliputi mekanisme, klasifikasi tingkat keparahanan dan dampak dari interaksi obat. Penelitian dilakukan secara observasional analitik dengan pengambilan data secara retrospektif pada bulan Januari-Maret 2023 menggunakan data resep dan rekam medik pasien diabetes melitus tipe 2 yang dirawat inap di Rumah Sakit Al Islam Bandung, teknik pengambilan sampel secara purposive sampling. Dari total 98 resep, terdapat 71 resep yang berpotensi mengalami interaksi obat. Terdiri dari jumlah obat 2-4 sebanyak 25 resep dengan potensi interaksi obat 29 (17,37%), sedangkan untuk jumlah obat ≥5 sebanyak 46 resep dengan potensi interaksi obat 138 (82,63%). Berdasarkan mekanisme interaksi obat yang terjadi terdiri dari farmakodinamik 142 (85,03%) dan farmakokinetik 25 (14,97%), dengan frekuensi tingkat keparahan mayor 5 (3%), moderate 152 (91%) dan minor 10 (6%). Penelitian ini Menggunakan E-Book Stockley’s Drug Interaction, Drug Interaction Checker serta Medscape Drug Interaction Checker untuk menganalisis interaksi obat.

PRESCRIBING IN GERIATRIC HYPERTENSIVE PATIENTS IN THE INPATIENT INSTALLATION OF RSUD R. SYAMSUDIN, S.H. SUKABUMI CITY Levina Geby Dwi Putri Alamsyah; Umi Yuniarni; Fetri Lestari
Bandung Conference Series: Pharmacy Vol. 3 No. 2 (2023): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v3i2.8407

Abstract. Geriatric patients are elderly patients with various diseases and / or diseases caused by physical, psychological, social, economic disorders and also experience a decrease in physiological function due to the degeneration process so that the body is susceptible to diseases and infectious diseases. One of the degenerative diseases that are commonly found in the elderly is hypertension. This study aims to determine the pattern of prescribing in geriatric hypertension patients at the Inpatient Installation of RSUD R. Syamsudin, S.H. including types of drugs, drugs for comorbidities, doses, and routes of administration. This research is a non-experimental research with a retrospective descriptive design. The results showed that the most widely prescribed antihypertensive drug was a single therapy class of Calcium Channel Blocker (CCB), the type of drug used was amlodipine. The composition of hypertensive patients without comorbidities was 75%, with comorbid heart disease by 15.69%, with comorbid diabetes mellitus and gout by 4%, with comorbid asthma by 2%. The most widespread use of antihypertensive drugs is given by monotherapy by 66%, a combination of 2 drugs by 22%, a combination of 3 drugs by 6%, and a combination of 4 drugs by 2%. Abstrak. Pasien geriatri adalah pasien lanjut usia dengan berbagai penyakit dan/atau penyakit yang diakibatkan oleh gangguan fisik, psikologis, sosial, ekonomi dan juga mengalami penurunan fungsi fisiologis akibat proses degenerasi sehingga tubuh rentan terhadap penyakit dan infeksi penyakit menular. Salah satu penyakit degeneratif yang banyak dijumpai pada lansia yaitu hipertensi. Penelitian ini bertujuan untuk mengetahui pola peresepan pada pasien hipertensi geriatri di Instalasi Rawat Inap RSUD R. Syamsudin, S.H. meliputi jenis obat, obat untuk penyakit penyerta, dosis, dan rute pemberian. Penelitian ini merupakan penelitian non eksperimental dengan rancangan deskriftif yang bersifat retrospektif. Hasil penelitian menunjukkan obat antihipertensi yang paling banyak diresepkan yaitu terapi tunggal golongan Calcium Channel Blocker (CCB) jenis obat yang digunakan adalah amlodipine. Komposisi pasien hipertensi tanpa penyakit penyerta sebesar 75%, dengan komorbid penyakit jantung sebesar 15,69%, dengan komorbid diabetes melitus dan asam urat sebesar 4%, dengan komorbid asma sebesar 2%. Penggunaan obat antihipertensi paling banyak digunakan yaitu dengan monoterapi sebesar 66%, kombinasi 2 obat sebesar 22%, kombinasi 3 obat sebesar 6%, dan kombinasi 4 obat sebesar 2%.

Kajian Literatur Profil Farmakokinetika Sacubitril-Valsartan Pada Subjek Sehat dan Gagal Jantung Firda Amelya; Ratih Aryani; Fetri Lestari
Bandung Conference Series: Pharmacy Vol. 3 No. 2 (2023): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v3i2.8536

Abstract. Sacubitril-Valsartan is a first-class therapeutic agent for ARNI (Angiotensin Receptor-Neprilysin Inhibitor) which can reduce blood pressure and reduce mortality and morbidity in patients with Heart failure with Reduced Ejection Fraction (HFrEF). A combination of Neprilysin inhibitors (NEPi) and Angiotensin II Receptor Blockers (ARBs) is required to reduce the increased bradykinin concentrations due to neprilysin inhibition. The success of Sacubitril-Valsartan therapy is determined by the dosage setting design taking into account pharmacokinetic factors. The pharmacokinetic profile of each individual may vary, influenced by differences in race/ethnicity, gender, age, drug interactions and physiological changes. This study aims to determine the pharmacokinetic parameters of the drug Sacubitril-Valsartan based on differences in race/ethnicity, sex, age, drug interactions, in subjects with impaired kidney function, and in subjects with heart failure. The method used for this study is the SLR (Systematic Literature Review) method. The articles used in this study were 10 journal articles obtained from the PMC database, Wiley, Springer Link. The results showed that race/ethnicity affects T1/2 longer in Caucasians, female sex has a longer T1/2, older people have a longer T1/2, Cmax, T1/2, AUC0-24h increased in impaired kidney function with decreased CL, Cmax and T1/2 increased in HFREF patients. Keywords: Pharmacokinetic, Sacubitril-Valsartan, Heart failure. Abstrak. Sacubitril-Valsartan merupakan agen terapeutik kelas pertama ARNI (Angiotensin Reseptor-Neprilysin Inhibitor) yang dapat menurunkan tekanan darah dan menurunkan mortalitas dan morbiditas pada pasien Heart failure with Reduced Ejection Fraction (HFrEF). Kombinasi Neprilysin inhibitor (NEPi) dan Angiotensin II Receptor Blockers (ARB) diperlukan untuk mengurangi konsentrasi bradikinin yang meningkat akibat penghambatan neprilysin. Keberhasilan terapi Sacubitril-Valsartan ditentukan oleh rancangan pengaturan dosis dengan mempertimbangkan faktor farmakokinetika. Profil farmakokinetika pada setiap individu dapat bervariasi dipengaruhi oleh perbedaan ras/etnis, jenis kelamin, usia, interaksi obat-obatan dan perubahan fisiologi. Penelitian ini bertujuan untuk mengetahui parameter farmakokinetika obat Sacubitril-Valsartan berdasarkan perbedaan ras/etnis, jenis kelamin, usia, interaksi obat-obatan, pada subjek dengan gangguan fungsi ginjal, dan pada subjek gagal jantung. Metode yang digunakan untuk penelitian ini adalah metode SLR (Systematic Literature Review). Artikel yang digunakan pada penelitian ini sebanyak 10 artikel jurnal yang diperoleh dari database PMC, Wiley, Springer Link. Hasil penelitian menunjukan bahwa ras/etnis mempengaruhi T1/2 lebih lama pada ras Kaukasia, jenis kelamin perempuan memiliki T1/2 lebih lama, usia tua memiliki T1/2 lebih lama, Cmax, T1/2, AUC0-24jam meningkat pada subjek gangguan fungsi ginjal dengan CL yang menurun, Cmax dan T1/2 meningkat pada pasien HFREF. Kata Kunci: Farmakokinetika, Sacubitril-Valsartan, Gagal Jantung.

Title

Found 5 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 5 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 5 Documents
Search