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All Journal Jurnal Respirologi Indonesia
Heri Wibowo
1 Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia 3 The Indonesia Pulmonary Mycoses Centre Faculty of Medicine Universitas Indonesia – National Respiratory Referral Hospital Persahabatan, Jakarta, Indonesia
Health Professions Medicine & Pharmacology

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Clinical Performance of the Aspergillus Western Blot IgG Kit for Serodiagnosis of Chronic Pulmonary Aspergillosis in Post-Tuberculosis Patients Anna Rozaliyani; Sresta Azahra; Findra Setianingrum; Heri Wibowo
Jurnal Respirologi Indonesia Vol 43, No 4 (2023)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v43i4.562

Abstract

Background: Chronic pulmonary aspergillosis (CPA) due to Aspergillus spp., causing slowly progressive destruction to lung parenchyma, is a major complication of pulmonary tuberculosis (TB). Detecting Aspergillus-specific IgG is critical for diagnosing CPA.Methods: We evaluated the performance of Aspergillus Western Blot (Asp-WB) IgG kit (LDBio Diagnostics, Lyon, France), a commercialized immunoblot assay for the diagnosis of CPA in 63 post-tuberculosis patients.Results: The sensitivity and specificity of Asp-WB were 50% and 93%. There was significant difference of Asp-WB positive results in probable CPA (n = 13) and non-CPA (n = 3) group (50% vs. 8%, p < 0.001). False negative results of Asp-WB were detected from non-fumigatus CPA that grew Aspergillus niger. CPA patients with mild symptoms (less than 3 months) indicated early progression of CPA might showed positive Asp-WB test resultd in low sensitivity of Asp-WB test.Conclusion: This study concluded that Asp-WB has potential to use as confirmatory test to assist diagnosis of CPA in post-TB patients. 
Co-Authors Anna Rozaliyani Findra Setianingrum Sresta Azahra