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All Journal Jurnal Klinik dan Riset Kesehatan Pediatric Sciences Journal Usada Nusantara: Jurnal Kesehatan Tradisional
Krisni Subandiyah
Divisi Nefrologi, Departemen Ilmu Kesehatan Anak, Fakultas Kedokteran Universitas Brawijaya, RSUD Dr. Saiful Anwar Provinsi Jawa Timur
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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The relation between vitamin D, calcium, and phosphor in growth retardation of child with chronic kidney disease Radwika Swastanti Wijaya; Ariani; Krisni Subandiyah
Pediatric Sciences Journal Vol. 3 No. 1 (2022): (Available online 1 June 2022)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v3i1.13

Abstract

Background: Growth retardation was a complication in chronic kidney disease (CKD). It is a condition that a child can not achieve linear potential growth. Fifty percent of children with CKD will have a height below the third percentile. The causes of growth disorders in CKD are multifactorial. Electrolyte hemostasis (calcium and phosphorus) and lack of vitamin D play a role in growth in children with CKD. The aim of this study was to determine the relationship between growth problems in children with chronic kidney disease and the correlation with vitamin D, calcium, and phosphorus. Method: This study was a retrospective observational analytical study design. The research subjects were taken from medical records from Saiful Anwar General Hospital in Malang from January 1st to December 2019. 68 pediatric patients aged 2 – 18 years old were diagnosed with chronic kidney disease, divided into 2 groups (with growth retardation and normal stature). Data were analyzed using SPSS v.26 for windows. Results: There was significant correlation between low vitamin D levels and growth retardation (p = 0.005), and significant correlation between calcium levels (p = 0.026) and phosphor levels (p = 0.222) and the incidence of growth retardation. Levels of vitamin D, calcium, and phosphor have a positive correlation with growth retardation 0.427, 0.277, dan 0.300 (p<0.05). Path analysis found a significant direct relationship between vitamin D on growth retardation (β = 0.358, p = 0.002) and had a greater effect when compared to the indirect relationship between vitamin D and growth retardation mediated by calcium and phosphorus. Conclusion: there is a correlation between vitamin D, calcium, and phosphorus with growth retardation in children with chronic kidney disease.
Pengaruh Permainan Edukasi “Puzzlo Puzzle” Terhadap Peningkatan Kemampuan Motorik Halus dan Kognitif Anak Usia 4-5 Tahun Lavenia Elizya STT; Krisni Subandijah; Mergy Gayatri
Usada Nusantara: Jurnal Kesehatan Tradisional Vol. 1 No. 2 (2023): Juli : USADA NUSANTARA
Publisher : Sekolah Tinggi Agama Buddha Nalanda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47861/usd.v1i2.378

Abstract

. Stimulation plays a crucial role in maximizing the growth and development of children by targeting their specific age-related cognitive and fine motor skills. This study aims to investigate the effectiveness of the educational toy "Puzzlo Puzzle" in improving the fine motor and cognitive abilities of children aged 4-5 years. The research design employed a pre-experimental approach with a one-group pretest-posttest design. A total of 36 participants were included, and primary data was collected through questionnaires assessing fine motor and cognitive development. The data were analyzed using frequency distribution tables and the paired t-test. The results indicated a significant relationship between the utilization of the puzzlo puzzle educational game and the improvement of both fine motor skills (p < 0.05) and cognitive abilities (p < 0.05) in children aged 4-5 years. Therefore, parents and educators should maximize the use of the "Puzzlo Puzzle" educational game in the child's educational journey.
Peran B Cell Activating Factor (BAFF) pada Penatalaksanaan Sindrom Nefrotik : Sebuah Paradigma Baru Astrid Kristina; Krisni Subandiyah
Jurnal Klinik dan Riset Kesehatan Vol 3 No 1 (2023): Edisi Oktober
Publisher : RSUD Dr. Saiful Anwar Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.03.1.5

Abstract

Nephrotic syndrome is a glomerular disease characterized by severe proteinuria (≥3g/24 hours), hypoalbuminemia (≤25g/L), and oedema, with hyperlipidemia in some cases. This syndrome can affect both children and adults of all ages and can be caused by idiopathic or primary causes, or secondary causes due to infectious diseases, systemic diseases, malignancies, diabetes, and the effect of drugs. Specific therapy in nephrotic syndrome is determined by histopathology and the underlying cause. B cells or B lymphocytes are part of a key part of mammals' immune response called humoral immunity. Production of B cells in humans is lifelong, beginning in the fetal liver intrauterine and then in the bone marrow after birth. B cells developed from hematopoietic stem cells. The developmental stages of B cells include all stages of initial differentiation, maturation, antigen interaction, and ultimately antibody synthesis. Until recently, nephrotic syndrome was considered a T-cell-mediated disease, new insights point to the potential role of B cells in the pathogenesis of nephrotic syndrome. One of the mechanisms that occurs is that B cells produce antibodies that bind to antigens on the surface of podocytes which are special cells in the glomerulus and play a key role in the filtration process. In both SSNS and SRNS, the causal mechanism for both is still unclear but is thought to have a close relationship with immune system disorders, especially B cells.
Co-Authors Ariani Astrid Kristina Lavenia Elizya STT Mergy Gayatri Radwika Swastanti Wijaya